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Serial-position effect as a biomarker in the diferential diagnosis of mild cognitive impairment. A multimodal biomarkers aproach. (P3.1-018)

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dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Martín, María Eugenia
dc.contributor.author Chrem Méndez, Patricio Alexis
dc.contributor.author Helou, María Belén
dc.contributor.author Clarens, María Florencia
dc.contributor.author Crivelli, Lucía
dc.contributor.author Allegri, Ricardo Francisco
dc.date.accessioned 2020-02-07T15:11:40Z
dc.date.available 2020-02-07T15:11:40Z
dc.date.issued 2019-04-09
dc.identifier.citation Calandri, I., Martín, M.E., Méndez, P.C., Helou, B., Clarens, M.F., Crivelli, L., Allegri, R. Serial-position effect as a biomarker in the diferential diagnosis of mild cognitive impairment. A multimodal biomarkers aproach. (P3.1-018). Neurology. 2019;92(15 Supplement). P3.1-018. en_US
dc.identifier.issn 1526-632X
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/183
dc.description.abstract Objective: To study the serial-position effect in a hippocampal disease as early stages of Alzheimer’s disease. Background: The serial-position effect, present in the learning of lists of words, is divided in primacy (PE) and a recency effect (RE), which consists of better recall of first and last elements respectively. Its study has provided insight into the memory system functioning. Design/Methods: Observational study with 168 subjects. Classified according to cognitive performance into mild amnestic cognitive impairment (aMCI) and cognitively normal (NC) and classified by their Alzheimer biomarkers profile (NCBk− = 31, NCBk + = 21, aMCIBk-=45 and aMCIBk + = 71). All subjects were studied with MRI, and voxel-based morphometry was performed to evaluate hippocampal volume. The Rey Auditory Verbal Learning Test (RAVLT) performance and serial position effect on learning and delayed memory were registered. Results: aMCI showed deficit in total learning and delayed recall compared with controls; the was no difference between biomarker profiles. In the first trial, the PE between CNBk− was significantly higher (p=0.03) compared with aMCIBk− and aMCIBk+. In total delayed recall there were non-significant differences between aMCI groups, but RE of delayed recall, showed a significantly better performance of aMCIBk− against aMCIBk+(p=0.028). RE in Trial6 and delayed recall correlated with T-tau levels (r2= −0.39, p= 0.01 and r2= −0.26 p= 0.027, respectively). Levels of Ab42, hippocampal volume and cortical thickness of the parahippocampal regions did not correlate with any of the effects. Conclusions: These results show that serial-position effect in the delayed recall is a measure superior to the conventional test scores for the detection of positive biomarkers in aMCI. This effect correlates with the increase in Tau-T in CSF but not with hippocampal volume. This finding suggests serial position effect could be a biomarker of neurodegeneration earlier than MRI. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Cognitive Dysfunction en_US
dc.subject Disfunción Cognitiva en_US
dc.subject Alzheimer Disease en_US
dc.subject Enfermedad de Alzheimer en_US
dc.subject tau Proteins en_US
dc.subject Proteínas tau en_US
dc.title Serial-position effect as a biomarker in the diferential diagnosis of mild cognitive impairment. A multimodal biomarkers aproach. (P3.1-018) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/other en_US
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Martín, María Eugenia. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Chrem Méndez, Patricio Alexis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Helou, María Belén. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Clarens, Florencia. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Crivelli, Lucía. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 92
dc.relation.ispartofNUMBER 15 Supplement
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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