Browsing Neurología Cognitiva by Subject "alpha-Synuclein"

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α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

Levin, Johannes; Baiardi, Simone; Quadalti, Corinne; Rossi, Marcello; Mammana, Angela; Vöglein, Jonathan; Bernhardt, Alexander; Perrin, Richard J.; Jucker, Mathias; Preische, Oliver; Hofmann, Anna; Höglinger, Günter U.; Cairns, Nigel; Franklin, Erin E.; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2024-04-26)

Introduction: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. Methods: ...

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