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Vasculitic Peripheral Neuropathy, differences between Systemic and Non-Systemic etiologies. (P2.4-008)

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dc.contributor.author Castiglione, Juan Ignacio
dc.contributor.author Marrodán, Mariano
dc.contributor.author Taratuto, Ana Lía
dc.contributor.author Alessandro, Lucas
dc.contributor.author Brand, Patricio
dc.contributor.author Barroso, Fabio Adrián
dc.date.accessioned 2020-12-11T12:58:05Z
dc.date.available 2020-12-11T12:58:05Z
dc.date.issued 2019-04-16
dc.identifier.citation Castiglione, J., Marrodan, M., Taratuto, A.L., Alessandro, L., Brand, P., Barroso, F.A. Vasculitic Peripheral Neuropathy, differences between Systemic and Non-Systemic etiologies (P2.4-008). Neurology. 2019;92(15 Supplement). P2.4-008 en_US
dc.identifier.uri https://n.neurology.org/content/92/15_Supplement/P2.4-008
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/262
dc.description.abstract Objective: The objective of this study is to differentiate the clinical presentation, complementary studies and evolution between the Systemic Vasculitis (SV) vs Non-Systemic Vasculitic Neuropathy (NSVN) attended in our center. Background: The inflammation of the vessels that causes the injury of the peripheral nerves is known as Vasculitic Peripheral Neuropathy (VPN). It can occur in the context of SV or NSVN. Design/Methods: In this retrospective analysis, we assessed medical records of patients diagnosed with VPN between 2002 and 2018. All the patients were evaluated clinically and diagnosed from the laboratory, neurophysiological study and peripheral nerve biopsy. The comparison between SV vs. NSVN was performed by parametric and non-parametric methods. Results: We included 23 patients with VPN confirmed by biopsy: n = 11 VS (eosinophilic granulomatosis with polyangiitis = 4, rheumatoid arthritis = 4, granulomatous with polyangiitis = 2, Sjögren syndrome = 1) and 12 NSVN. The average age of presentation was 67 and 71 years respectively. The M:F ratio was 1: 1. The diagnostic delay was higher in NSVN (11.5 months vs. 5 months, p = 0.0037). High values of erythrocyte sedimentation rate (ESR) were more frequent in patients with SV (100% vs. 58%, p = 0.03). The most frequent form of presentation was mononeuritis multiplex (86.9%), followed by asymmetric polyneuropathy (8.7%) and symmetric (4.4%). All patients received initial treatment with corticosteroids, while 16 required other immunosuppressive drugs: cyclophosphamide (7), intravenous Immunoglobulin (6), methotrexate (5), azathioprine (3) or rituximab (2). The majority evolved with relapses that led to therapeutic scaling (8). Conclusions: Neuropathies iniciated as mononeuritis multiplex should make us suspect VPN, although this is not the only form of presentation. Systemic compromise, elevated ESR and specific antibodies point to SV. Nerve biopsy should be performed early, considering that this is the gold standard for diagnosis and it can change the prognosis of these diseases. Disclosure: Dr. Castiglione has nothing to disclose. Dr. Marrodan has nothing to disclose. Dr. Taratuto has nothing to disclose. Dr. Alessandro has nothing to disclose. Dr. Brand has nothing to disclose. Dr. Barroso has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer. Dr. Barroso has received research support from Alnylam. en_US
dc.language.iso eng en_US
dc.publisher AAN en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Peripheral Nervous System Diseases en_US
dc.subject Enfermedades del Sistema Nervioso Periférico en_US
dc.subject Peripheral Neuropathy en_US
dc.subject Neuropatía Periférica en_US
dc.title Vasculitic Peripheral Neuropathy, differences between Systemic and Non-Systemic etiologies. (P2.4-008) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/other en_US
dc.description.fil Fil: Castiglione, Juan Ignacio. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Taratuto, Ana Lía. Fleni. Departamento de Neuropatología y Biología Molecular. Centro de Referencia Neuropatológico de Encefalopatías Espongiformes Transmisibles; Argentina.
dc.description.fil Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Brand, Patricio. Fleni. Departamento de Neurología. Servicio de Neurofisiología; Argentina.
dc.description.fil Fil: Barroso, Fabio Adrián. Fleni. Departamento de Neurología. Sección de Enfermedades Neuromusculares; Argentina.
dc.relation.ispartofVOLUME 92
dc.relation.ispartofNUMBER 15
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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