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Corticosteroids affect the dynamics of multiple sclerosis lesions formation (P3.2-079)

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dc.contributor.author Gaitán, María Inés
dc.contributor.author De Pino, Gabriela
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Michelin, Gabriela
dc.contributor.author Yáñez, Paulina
dc.contributor.author Correale, Jorge
dc.date.accessioned 2020-12-16T13:45:53Z
dc.date.available 2020-12-16T13:45:53Z
dc.date.issued 2019-05-07
dc.identifier.citation Gaitán, M., De Pino, G., Ysrraelit, M., Michelin, G., Yañez, P., Correale, J. Corticosteroids affect the dynamics of multiple sclerosis lesions formation (P3.2-079). Neurology. 2019;92(15 Supplement). P3.2-079 en_US
dc.identifier.uri https://n.neurology.org/content/92/15_Supplement/P3.2-079/tab-article-info
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/268
dc.description.abstract Objective: To obtain in-vivo evidence of early dynamics of multiple sclerosis (MS) lesions formation and changes that corticosteroids may induce. Background: MRI showed that the development of MS lesions is dynamic and heterogeneous. Lesions grow outward from a central vein comprising disruption of the blood-brain-barrier (BBB) illustrated in the centrifugal enhancement proved by dynamic contrast–enhanced (DCE) MRI; in some of them, a substantial immune reaction at the edge of the lesion, opens the BBB in the capillaries mirrored as the centripetal enhancement by DCE. The latter, previously called ring-like, are associated with more severe tissue damage and may show a paramagnetic-rim, which persistency may represent failure of lesion repair and in later stages, smoldering lesions. Design/Methods: Six relapsing patients were scanned in a General Electric 3.0 tesla scanner. T2-weighted, susceptibility-weighted, T1-weighted (before/after gadolinium), and DCE scans were acquired at baseline, days 5, 10 and 30 post-exacerbation. Half of the patients were infused with methylprednisolone 1000mg/5days, immediately after baseline MRI. For each enhancing-lesion, dynamic of enhancement, size, and phase appearance, were assessed at each time-point. Results: Fifty-seven lesions were analyzed; centrifugal lesions (n=45) were smaller (4.5mm) than 15 centripetal ones (10.5 mm); eight centripetal showed a paramagnetic-rim. Three patients not treated with corticosteroids developed 19 lesions, 8/9(88%) at baseline were centrifugal (1 centripetal); at day 30, 7/9(70%) lesions were centripetal (2 centrifugal). Three patients treated with methylprednisolone had 38 lesions, 28/31(90%) at baseline were centrifugal (3 centripetal), most of enhancement transiently or definitely disappeared at second time-point. At day 30, 3/11 were centripetal (27%) (8 centrifugal). Conclusions: Corticosteroids seem to be effective for closing transiently/definitely the BBB of most active lesions and notably for preventing the shift to centripetal enhancement, probably eluding the stronger immune reaction at the edge of the developing lesion. This may portend less chronic tissue damage. en_US
dc.language.iso eng en_US
dc.publisher AAN en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Adrenal Cortex Hormones en_US
dc.subject Corticoesteroides en_US
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.title Corticosteroids affect the dynamics of multiple sclerosis lesions formation (P3.2-079) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/other en_US
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: De Pino, Gabriela. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Ysrraelit, Maria Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Michelin, Gabriela. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Yañez, Paulina. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 92
dc.relation.ispartofNUMBER 15
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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