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Predictors of favorable response to the placement of the ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus (P4.3-071)

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dc.contributor.author Ricciardi, Mario Emiliano
dc.contributor.author Alessandro, Lucas
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Farez, Mauricio Franco
dc.contributor.author Villalonga, Juan Francisco
dc.contributor.author Fausti, Martín
dc.contributor.author Herrmann, Frida
dc.contributor.author Allegri, Ricardo Francisco
dc.date.accessioned 2020-12-21T14:14:59Z
dc.date.available 2020-12-21T14:14:59Z
dc.date.issued 2019-05-08
dc.identifier.citation Ricciardi, M., Alessandro, L., Calandri, I., Farez, M., Villalonga, J., Fausti, M., Herrmann, F., Allegri, R. Predictors of favorable response to the placement of the ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus (P4.3-071). Neurology. 2019;92(15 Supplement). P4.3-071 en_US
dc.identifier.uri https://n.neurology.org/content/92/15_Supplement/P4.3-071.abstract
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/277
dc.description.abstract Objective: Search for clinical factors and complementary studies, in order to determine predictors of a favorable response to the placement of ventriculoperitoneal shunt (VPS) in patients with idiopathic normal pressure hydrocephalus (iNPH). Background: The indication of VPS is discussed in patients with iNPH, due to the heterogeneity of the response to treatment and the risks involved in neurosurgery. Design/Methods: Retrospective review of medical records of patients with iNPH treated with VPS assisted in our institution from January 2014 to January 2017. Clinical data and complementary studies were recorded (brain MRI and CT, gait test post-lumbar puncture). Clinical response was evaluated with the Modified Rankin Scale (mRS) at baseline and 12 months of follow-up. A univariate statistical analysis of the variables considered as possible prognostic factors was performed. Results: 58 patients were included. Among the clinical factors: female presented 3.68 times more chances of improvement after the VPS (p = 0.019), while age, time of evolution of the clinical manifestations and MMSE had no correlation. Regarding the complementary studies: good response to the gait test was associated with better response to the VPS (p = 0.024) and each degree of increase in the angle of the callosum was associated with a 5% reduction in the possibility of improvement, although this effect was not significant (p = 0.08); the Evans index, the presence of Disproportionately Enlarged Subarachnoid space Hydrocephalus (DESH) and the degree of Fazekas had no prognostic correlation. Conclusions: Female and good response to the gait test could be considered as predictors of a favorable response to the placement of VPS in patients with iNPH. A prospective study is necessary to achieve a homogeneous diagnostic evaluation and a more extensive longitudinal follow-up to evaluate the clinical evolution in this group of patients. en_US
dc.language.iso eng en_US
dc.publisher AAN en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Ventriculoperitoneal Shunt en_US
dc.subject Derivación Ventriculoperitoneal en_US
dc.subject Idiopathic Normal Pressure Hydrocephalus en_US
dc.subject Hidrocefalia de Presión Normal en_US
dc.title Predictors of favorable response to the placement of the ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus (P4.3-071) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/other en_US
dc.description.fil Fil: Ricciardi, Mario Emiliano. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina. Fleni. Clínica de Esclerosis Lateral Amiotrófica; Argentina.
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina.
dc.description.fil Fil: Villalonga, Juan Francisco. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Fausti, Martín. Fleni. Departamento de Neurocirugía; Argentina.
dc.description.fil Fil: Herrmann, Frida. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME 15
dc.relation.ispartofNUMBER 15
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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