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Distinct Neural Processing of Acute Stress in Major Depression and Borderline Personality Disorder

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dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Wainsztein, Agustina Edith
dc.contributor.author Álvarez Mercé, Rocío
dc.contributor.author Goldberg, Ximena
dc.contributor.author Castro, Mariana Nair
dc.contributor.author Brusco, Luis Ignacio
dc.contributor.author Ladrón de Guevara, Soledad
dc.contributor.author Bodurka, Jerzy
dc.contributor.author Paulus, Martin
dc.contributor.author Menchón, José Manuel
dc.contributor.author Soriano-Mas, Carles
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2021-03-23T16:22:20Z
dc.date.available 2021-03-23T16:22:20Z
dc.date.issued 2021-02-26
dc.identifier.citation Villarreal, M.F., Wainsztein, A.E., Merce, R.Á., Goldberg, X., Castro, M.N., Brusco, L.I., de Guevara, S.L., Bodurka, J., Paulus, M., Menchón, J.M., Soriano-Mas, C., Guinjoan, S.M., 2021. Distinct Neural Processing of Acute Stress in Major Depression and Borderline Personality Disorder. Journal of Affective Disorders 286, 123–133. https://doi.org/10.1016/j.jad.2021.02.055 es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/387
dc.identifier.uri https://doi.org/10.1016/j.jad.2021.02.055
dc.description.abstract Background: Major depressive disorder (MDD) and borderline personality disorder (BPD) are highly prevalent and often comorbid psychiatric conditions, with abnormal processing of negative affect resulting from psychological stress. Characteristics of central processing of autonomic response to stress in each disorder are not clearly settled. Methods: We obtained whole brain 3T fMRI with concurrent skin conductance, respiration rate, and heart rate variability measures in a cohort of MDD (N=19), BPD (N=19) patients, and healthy (N=20) individuals. Experiments were conducted in resting conditions, during a control mental arithmetic task, during highly stressful mental arithmetic, and in the period immediately following psychological stress. Results: Widespread activation of central autonomic network (CAN) structures was observed during stress compared to a control task in the group of healthy participants, whereas CAN activation during stress was less intense in both BPD and MDD. Both patient groups displayed increased sympathetic and decreased parasympathetic activation compared to healthy subjects, as previously reported. The relationship between peripheral sympathetic or parasympathetic activity and simultaneous regional brain BOLD activity was similar in BPD patients and healthy subjects, and markedly different from that seen in MDD patients. Limitations: The sample size, the fact it belonged to a single study site, and low grade affective symptomatology in both patient groups limit the generalizability of the present findings. Conclusions: The diverging neurobiological signature in the homeostatic response to stress in MDD and BPD possibly represents a heuristically valuable candidate biomarker to help discern MDD and BPD patients. es_ES
dc.description.uri https://doi.org/10.1016/j.jad.2021.02.055
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Depressive Disorder, Major es_ES
dc.subject Trastorno Depresivo Mayor es_ES
dc.subject Borderline Personality Disorder es_ES
dc.subject Trastorno de Personalidad Limítrofe es_ES
dc.subject Stress Disorders es_ES
dc.subject Trastornos de Estrés es_ES
dc.title Distinct Neural Processing of Acute Stress in Major Depression and Borderline Personality Disorder es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Wainsztein, Agustina Edith. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Álvarez Merce, Rocío. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Goldberg, Ximena. Institut d'Investigació i Innovació Parc Taulí; España.
dc.description.fil Fil: Castro, Mariana Nair. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.description.fil Fil: Brusco, Luis Ignacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.description.fil Fil: Ladrón de Guevara, Soledad. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Bodurka, Jerzy. Laureate Institute for Brain Research; Estados Unidos.
dc.description.fil Fil: Paulus, Martin. Laureate Institute for Brain Research; Estados Unidos.
dc.description.fil Fil: Menchón, José Manuel. Bellvitge University Hospital; España.
dc.description.fil Fil: Soriano-Mas, Carles. Bellvitge University Hospital; España.
dc.description.fil Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina. Laureate Institute for Brain Research; Estados Unidos.
dc.relation.ispartofVOLUME 286
dc.relation.ispartofPAGINATION 123-133
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Journal of affective disorders
dc.relation.ispartofISSN 1573-2517
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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