DSpace Repository

Central Autonomic Network Association With Cardiac Autonomic Sleep-Wake Rhythm in Major Depression and Borderline Personality Disorder

Show simple item record

dc.contributor.author Wainsztein, Agustina Edith
dc.contributor.author Camacho Téllez, Vicente
dc.contributor.author Abulafia, Carolina
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Soriano-Mas, Carles
dc.contributor.author Nemeroff, Charles B.
dc.contributor.author Guinjoan, Salvador Martín
dc.contributor.author Castro, Mariana Nair
dc.date.accessioned 2021-05-13T14:19:01Z
dc.date.available 2021-05-13T14:19:01Z
dc.date.issued 2021-04-27
dc.identifier.citation Wainsztein, A., Camacho, V., Abulafia, C., Villarreal, M.F., Soriano-Mas, C., Nemeroff, C.B., Guinjoan, S.M., Castro, M.N., 2021. Central Autonomic Network Association With Cardiac Autonomic Sleep-Wake Rhythm in Major Depression and Borderline Personality Disorder. Biological Psychiatry 89, S385. https://doi.org/10.1016/j.biopsych.2021.02.957 es_ES
dc.identifier.uri https://doi.org/10.1016/j.biopsych.2021.02.957
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/478
dc.description.abstract Background Resting heart rate variability (HRV), a measure of ANS activity, adaptability and health, has been shown to be altered in patients with Major Depressive Disorder (MDD) and Borderline Personality disorder (BPD). The Central Autonomic Network (CAN) comprises brain regions involved in both physiological and behavioral regulation. Evidence linking cortical thickness of CAN components and HRV circadian patterns is scarce. We explored this relationship in patients with BPD, MDD and healthy controls (CS). Methods Forty-two participants (15 BPD, 14 MDD, 13HC) underwent 24hr-HRV recordings following structural MRI. Cortical thickness analysis was performed (FreeSurfer). Sleep-wake HRV measures (i.e, HF and RMSSD) were calculated. Cortical thickness of CAN regions were tested as HRV predictors. Results Cortical thickness of right anterior cingulate and lateral orbitofrontal cortex predicted 50% of RMSSD (p=.023) and 58% of HF (p=.008) nocturnal variation respectively in BPD patients where greater cortical thickness was associated with increased HRV. HC exhibited this association between left inferior frontal gyrus (IFG) and middle frontal gyrus areas and sleep-HRV(p<.05). Left triangular segment of IFG explained 86% variability of nocturnal RMSSD in this group (p=.001). MDD group did not show significant correlations. Conclusions Greater cortical thickness of CAN regions may be associated with increased sleep-HRV in BPD patients and HC. Nocturnal HRV patterns could serve as a biomarker of preserved neural architecture and functioning. Neural correlates of HRV may provide important insights into mechanisms involved in self-regulation that might be related to emotional well-being or psychopathology. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Autonomic Nervous System es_ES
dc.subject Sistema Nervioso Autónomo es_ES
dc.subject Depressive Disorder, Major es_ES
dc.subject Trastorno Depresivo Mayor es_ES
dc.subject Borderline Personality Disorder es_ES
dc.subject Trastorno de Personalidad Limítrofe es_ES
dc.title Central Autonomic Network Association With Cardiac Autonomic Sleep-Wake Rhythm in Major Depression and Borderline Personality Disorder es_ES
dc.type info:eu-repo/semantics/other es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Wainsztein, Agustina Edith. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Camacho Téllez, Vicente. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Abulafia, Carolina. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Soriano-Mas, Carles. Bellvitge Biomedical Research Institute; España.
dc.description.fil Fil: Nemeroff, Charles B. Dell Medical School at The University of Texas at Austin; Estados Unidos.
dc.description.fil Fil: Guinjoan, Salvador Martín. Fleni. Servicio de Psiquiatría; Argentina. Laureate Institute for Brain Research; Estados Unidos.
dc.description.fil Fil: Castro, Mariana Nair. Fleni. Instituto de Neurociencias FLENI-CONICET. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.relation.ispartofVOLUME 89
dc.relation.ispartofNUMBER 9
dc.relation.ispartofPAGINATION S385
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Biological psychiatry
dc.relation.ispartofISSN 1873-2402
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess

Search DSpace


Browse

My Account

Statistics