Neurociencias: Recent submissions

  • Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings 
    Pallavicini, Carla; Cavanna, Federico; Zamberlan, Federico; de la Fuente, Laura A.; Ilksoy, Yayla; Perl, Yonatan Sanz; Arias, Mauricio; Romero, Celeste; Carhart-Harris, Robin; Timmermann, Christopher; Tagliazucchi, Enzo (Sage, 2021-02-10)
    Background: N,N-dimethyltryptamine is a short-acting psychedelic tryptamine found naturally in many plants and animals. Few studies to date have addressed the neural and psychological effects of N,N-dimethyltryptamine ...
  • Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle 
    Waisman, Ariel; Norris, Alessandra; Costa, Martín Elías; Kopinke, Daniel (Nature Publishing Group, 2021-01-22)
    Skeletal muscle has the remarkable ability to regenerate. However, with age and disease muscle strength and function decline. Myofiber size, which is affected by injury and disease, is a critical measurement to assess ...
  • HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapy 
    Palma, María Belén; Tronik-Le Roux, Diana; Amín, Guadalupe; Castañeda, Sheila; Möbbs, Alan Miqueas; Scarafía, María Agustina; La Greca, Alejandro; Daouya, Marina; Poras, Isabelle; Inda, Ana María; Moro, Lucía Natalia; Carosella, Edgardo D.; García, Marcela N.; Miriuka, Santiago Gabriel (bioRxiv, 2021-01-22)
    Cancer immunotherapies based mainly on the blockade of immune-checkpoint (IC) molecules by anti-IC antibodies offer new alternatives for treatment in oncological diseases. However, a considerable proportion of patients ...
  • miR-302 family, miR-145 and miR-296 temporal expression profile along the cell cycle of human pluripotent stem cells 
    Rodríguez Varela, María Soledad; Mucci, Sofía; Videla Richardson, Guillermo Agustín; Isaja, Luciana; Sevlever, Gustavo Emilio; Scassa, María Élida; Romorini, Leonardo (Elsevier, 2021-01-21)
    Human pluripotent stem cells (hPSCs), like embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), exhibit an unusual cell cycle structure characterized by a short G1 phase and cells being most of time in S phase. ...
  • Downregulation of E-cadherin in pluripotent stem cells triggers partial EMT 
    Aban, Cyntia; Lombardi, Antonella; Neiman, Gabriel; Biani, María Celeste; La Greca, Alejandro; Waisman, Ariel; Moro, Lucía Natalia; Sevlever, Gustavo Emilio; Miriuka, Santiago Gabriel; Luzzani, Carlos Daniel (Nature Publishing Group, 2021-01-21)
    Epithelial to mesenchymal transition (EMT) is a critical cellular process that has been well characterized during embryonic development and cancer metastasis and it also is implicated in several physiological and pathological ...
  • Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification 
    Schottlaender, Lucía V.; Abeti, Rosella; Jaunmuktane, Zane; Macmillan, Carol; Chelban, Viorica; O'Callaghan, Benjamin; McKinley, John; Maroofian, Reza; Efthymiou, Stephanie; Athanasiou Fragkouli, Alkyoni; Forbes, Raeburn; Soutar, Marc P.M.; Livingston, John H.; Kalmar, Bernardett; Swayne, Orlando; Hotton, Gary; SYNAPS Study Group; Pittman, Alan; Launchbury, Francesca; Mendes de Oliveira, João Ricardo; de Grandis, Maria; Richard Loendt, Angela; Althonayan, Juri; McDonnell, Gavin; Carr, Aisling; Khan, Suliman; Beetz, Christian; Bisgin, Atil; Bozdogan, Sevcan Tug; Begtrup, Amber; Torti, Erin; Greensmith, Linda; Giunti, Paola; Morrison, Patrick J.; Brandner, Sebastian; Aurrand-Lions, Michel; Houlden, Henry (Cell Press, 2020-02-05)
    Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To ...
  • Embryo aggregation and adipose-derived mesenchymal donor cells in bovine somatic cell nuclear transfer 
    Alberio, Virgilia; Savy, Virginia; Vans Landschoot, Geraldina; Moro, Lucía Natalia; Olea, Fernanda Daniela; Rodríguez Álvarez, L.; Salamone, Daniel Felipe (Csiro Publishing, 2021-01-08)
    Somatic cell nuclear transfer (SCNT) is a powerful tool, but its efficiency remains low. The use of less differentiated donor cells or the embryo aggregation (EA) strategy improves the SCNT rates in several species. It ...
  • Myostatin gene editing by CRISPR/Cas9 technology of Brangus fetal fibroblasts to produce edited embryos by cloning 
    Bastón, Juan Ignacio; Viale, Diego Luis; Olguín, Martín; Wiedenmann, Elisabet; Arnold, Victoria; Suva, Mariana; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Moro, Lucía Natalia; Vichera, Gabriel (Csiro Publishing, 2021-01-08)
    Some European cattle breeds, such as Charolais and Maine Anjou, have natural mutations in the myostatin gene (MSTN) that inhibit its expression and result in an increase in muscle mass and protein content. An innovative ...
  • Meditation Increases the Entropy of Brain Oscillatory Activity 
    Martínez Vivot, Rocío; Pallavicini, Carla; Zamberlan, Federico; Vigo, Daniel Eduardo; Tagliazucchi, Enzo (Elsevier, 2020-04-01)
    We address the hypothesis that the entropy of neural dynamics indexes the intensity and quality of conscious content. Previous work established that serotonergic psychedelics can have a dysregulating effect on brain activity, ...
  • PIWI-interacting RNAs are differentially expressed during cardiac differentiation of human pluripotent stem cells 
    La Greca, Alejandro; Scarafía, María Agustina; Hernández Cañás, María Clara; Pérez, Nelba; Castañeda, Sheila; Colli, Carolina; Miqueas Möbbs, Alan; Santín Velazque, Natalia Lucía; Neiman, Gabriel; Garate, Ximena; Aban, Cyntia; Waisman, Ariel; Moro, Lucía Natalia; Sevlever, Gustavo Emilio; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel (Public Library of Science, 2020-05-05)
    PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be restricted exclusively to germline cells. In recent years, accumulating evidence has demonstrated that piRNAs are actually expressed in ...
  • Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives 
    Pallavicini, Carla; Vilas, Martina G.; Villarreal, Mirta Fabiana; Zamberlan, Federico; Muthukumaraswamy, Suresh; Nutt, David; Carhart-Harris, Robin; Tagliazucchi, Enzo (Elsevier, 2019-06-24)
    Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective ...
  • Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39 
    Takenaka, Maisa C.; Gabriely, Galina; Rothhammer, Veit; Mascanfroni, Ivan D.; Wheeler, Michael A.; Chao, Chun-Cheih; Gutiérrez-Vázquez, Cristina; Kenison, Jessica; Tjon, Emily C.; Barroso, Andreia; Vandeventer, Tyler; Alves de Lima, Kalil; Rothweiler, Sonja; Mayo, Lior; Ghannam, Soufiene; Zandee, Stephanie; Healy, Luke; Sherr, David; Farez, Mauricio Franco; Prat, Alexandre; Antel, Jack; Reardon, David A.; Zhang, Hailei; Robson, Simon C.; Getz, Gad; Weiner, Howard L.; Quintana, Francisco J. (Nature Publishing Group, 2019-04-08)
    Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we ...
  • Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells 
    Morris-Hanon, Olivia; Marazita, Mariela Claudia; Romorini, Leonardo; Isaja, Luciana; Fernandez-Espinosa, Damián Darío; Sevlever, Gustavo Emilio; Scassa, María Élida; Videla Richardson, Guillermo Agustín (Springer, 2019-05-23)
    Glioblastoma multiforme is the most aggressive primary brain tumor. Current knowledge suggests that the growth and recurrence of these tumors are due in part to the therapy-resistant glioma stem cell subpopulation, which ...
  • R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome 
    Mesquita, Fernanda C.P.; Arantes, Paulo C.; Kasai-Brunswick, Tais Hanae; Araujo, Dayana S.; Gubert, Fernanda; Monnerat, Gustavo; Silva dos Santos, Danúbia; Neiman, Gabriel; Leitão, Isabela C.; Barbosa, Raiana A. Q.; Coutinho, Jorge L.; Vaz, Isadora M.; dos Santos, Marcus N.; Borgonovo, Tamara; Cruz, Fernando E. S.; Miriuka, Santiago Gabriel; Medei, Emiliano H.; Campos de Carvalho, Antonio C.; Carvalho, Adriana B. (Nature Publishing Group, 2019-12-16)
    Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 ...
  • Deep Learning Neural Networks Highly Predict Very Early Onset of Pluripotent Stem Cell Differentiation 
    Waisman, Ariel; La Greca, Alejandro; Möbbs, Alan Miqueas; Scarafía, María Agustina; Santín Velazque, Natalia Lucía; Neiman, Gabriel; Moro, Lucía Natalia; Luzzani, Carlos Daniel; Sevlever, Gustavo Emilio; Guberman, Alejandra S.; Miriuka, Santiago Gabriel (Elsevier, 2019-04-09)
    Deep learning is a significant step forward for developing autonomous tasks. One of its branches, computer vision, allows image recognition with high accuracy thanks to the use of convolutional neural networks (CNNs). Our ...
  • Cell cycle dynamics of mouse embryonic stem cells in the ground state and during transition to formative pluripotency 
    Waisman, Ariel; Sevlever, Federico; Costa, Martín Elías; Cosentino, María Soledad; Miriuka, Santiago Gabriel; Ventura, Alejandra C.; Guberman, Alejandra S. (Nature Publishing Group, 2019-05-29)
    Mouse embryonic stem cells (mESCs) can be maintained as homogeneous populations in the ground state of pluripotency. Release from this state in minimal conditions allows to obtain cells that resemble those of the early ...
  • Analysis of the expression of PIWI-interacting RNAs during cardiac differentiation of human pluripotent stem cells 
    La Greca, Alejandro; Scarafía, María Agustina; Hernández Cañás, María Clara; Pérez, Nelba; Castañeda, Sheila; Colli, Carolina; Miqueas Möbbs, Alan; Santín Velazque, Natalia Lucía; Neiman, Gabriel; Garate, Ximena; Aban, Cyntia; Waisman, Ariel; Moro, Lucía Natalia; Sevlever, Gustavo Emilio; Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel (bioRxiv, 2019-05-21)
    El artículo es un preprint que aún no ha pasado por revisión por pares PIWI-interacting RNAs (piRNAs) are a class of non-coding RNAs initially thought to be restricted almost exclusively to germ line cells. In recent ...
  • Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity 
    Gonano, Luis A.; Sepúlveda, Marisa; Morell, Malena; Toteff, Tamara; Racioppi, María Florencia; Lascano, Elena; Negroni, Jorge; Fernández Ruocco, María Julieta; Medei, Emiliano H.; Neiman, Gabriel; Miriuka, Santiago Gabriel; Back, Thomas G.; Wayne Chen, S.R.; Mattiazzi, Alicia; Vila Petroff, Martin (Japanese Circulation Society, 2018-12-25)
    Background: It has been shown that carvedilol and its non β-blocking analog, VK-II-86, inhibit spontaneous Ca2+ release from the sarcoplasmic reticulum (SR). The aim of this study is to determine whether carvedilol and ...
  • Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation 
    Cosentino, María Soledad; Oses, Camila; Vázquez Echegaray, Camila; Solari, Claudia; Waisman, Ariel; Álvarez, Yanina; Petrone, María Victoria; Francia, Marcos; Schultz, Marcelo; Sevlever, Gustavo Emilio; Miriuka, Santiago Gabriel; Levi, Valeria; Guberman, Alejandra S. (Academic Press, 2019-03-15)
    Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs that occur during development and stem cell differentiation. The histone acetyltransferase Kat6b is relevant for neurogenesis in ...
  • Retrieval of Retrained and Reconsolidated Memories Are Associated With a Distinct Neural Network 
    Bavassi, Luz; Forcato, Cecilia; Fernández, Rodrigo Sebastián; De Pino, Gabriela; Pedreira, María Eugenia; Villarreal, Mirta Fabiana (Nature Publishing Group, 2019-01-28)
    Consolidated memories can persist from a single day to years, and persistence is improved by retraining or retrieval-mediated plasticity. One retrieval-based way to strengthen memory is the reconsolidation process. ...

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