Neurociencias: Envíos recientes

  • Generation of myostatin knockout horse embryos using clustered regularly interspaced short palindromic repeats/CRISPR-associated gene 9 and somatic cell nuclear transfer 
    Vichera, Gabriel; Viale, Diego Luis; Olivera, Ramiro; Arnold, Victoria; Grundnig, A.; Bastón, Juan Ignacio; Miriuka, Santiago Gabriel; Moro, Lucía Natalia (Csiro Publishing, 2018-12-03)
    Historically, livestock improvement by selective breeding was the principal selection force in animal production and welfare, but the desired phenotype may involve more than 1 generation. Nowadays, new technologies such ...
  • Integrin alpha-5 subunit is critical for the early stages of human pluripotent stem cell cardiac differentiation 
    Neiman, Gabriel; Scarafía, María Agustina; La Greca, Alejandro; Santín Velazque, Natalia Lucía; Garate, Ximena; Waisman, Ariel; Möbbs, Alan Miqueas; Kasai-Brunswick, Tais Hanae; Mesquita, Fernanda C.P.; Martire-Greco, Daiana; Moro, Lucía Natalia; Luzzani, Carlos Daniel; Bastos Carvalho, Adriana; Sevlever, Gustavo Emilio; Campos de Carvalho, Antonio C.; Guberman, Alejandra S.; Miriuka, Santiago Gabriel (Nature Publishing Group, 2019-12-02)
    The stem cell niche has a strong influence in the differentiation potential of human pluripotent stem cells with integrins playing a major role in communicating cells with the extracellular environment. However, it is not ...
  • The lateral neocortex is critical for contextual fear memory reconsolidation 
    de la Fuente, Verónica; Medina, Candela; Falasco, Germán; Urrutia, Leandro; Kravitz, Alexxai V.; Urbano, Francisco J.; Vázquez, Silvia; Pedreira, María Eugenia; Romano, Arturo (Nature Publishing Group, 2019-08-21)
    Memories are a product of the concerted activity of many brain areas. Deregulation of consolidation and reprocessing of mnemonic traces that encode fearful experiences might result in fear-related psychopathologies. Here, ...
  • Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or Nanoghas different effect on teratoma growth 
    Schlee Villodre, Emilly; Bettega Felipe, Karina; Zanotta Oyama, Mayumi; Hehn de Oliveira, Francine; da Costa Lopez, Patrícia Luciana; Solari, Claudia; Sevlever, Gustavo Emilio; Guberman, Alejandra S.; Lenz, Guido (Elsevier, 2019-07-25)
    Induced pluripotent stem cells (iPSC) have a great potential, but their clinical application depends on finding strategies to abolish their tumorigenic potential. The use of Oct4, Sox2, Klf4, c-Myc and Nanog to generate ...
  • Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine 
    Videla Richardson, Guillermo Agustín; Furmento, Verónica Alejandra; García, Carolina Paola; Morris-Hanon, Olivia; Sevlever, Gustavo Emilio; Romorini, Leonardo; Scassa, María Élida (Biomed Central, 2019-08-28)
    BACKGROUND: The essentially unlimited expansion potential and the pluripotency of human embryonic stem cells (hESCs) make them attractive for cell-based therapeutic purposes. Although hESCs can indefinitely proliferate ...
  • The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells 
    Solari, Claudia; Petrone, María Victoria; Toro, Ayelén; Vázquez Echegaray, Camila; Cosentino, María Soledad; Waisman, Ariel; Francia, Marcos; Barañao, Lino; Miriuka, Santiago Gabriel; Guberman, Alejandra S. (Biomed Central, 2019-07-01)
    OBJECTIVE: Redox homeostasis maintenance is essential to bring about cellular functions. Particularly, embryonic stem cells (ESCs) have high fidelity mechanisms for DNA repair, high activity of different antioxidant enzymes ...
  • The avalanche-like behaviour of large-scale haemodynamic activity from wakefulness to deep sleep 
    Bocaccio, Hernán; Pallavicini, Carla; Castro, Mariana Nair; Sánchez, Stella Maris; De Pino, Gabriela; Laufs, Helmut; Villarreal, Mirta Fabiana; Tagliazucchi, Enzo (Royal Society, 2019-09-11)
    Increasing evidence suggests that responsiveness is associated with critical or near-critical cortical dynamics, which exhibit scale-free cascades of spatio-temporal activity. These cascades, or 'avalanches', have been ...

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