Browsing Neurociencias.artículos by Author "Medei, Emiliano H."

Now showing items 1-2 of 2

Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity

Gonano, Luis A.; Sepúlveda, Marisa; Morell, Malena; Toteff, Tamara; Racioppi, María Florencia; Lascano, Elena; Negroni, Jorge; Fernández Ruocco, María Julieta; Medei, Emiliano H.; Neiman, Gabriel; Miriuka, Santiago Gabriel; Back, Thomas G.; Wayne Chen, S.R.; Mattiazzi, Alicia; Vila Petroff, Martin (Japanese Circulation Society, 2018-12-25)

Background: It has been shown that carvedilol and its non β-blocking analog, VK-II-86, inhibit spontaneous Ca2+ release from the sarcoplasmic reticulum (SR). The aim of this study is to determine whether carvedilol and ...
R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome

Mesquita, Fernanda C.P.; Arantes, Paulo C.; Kasai-Brunswick, Tais Hanae; Araujo, Dayana S.; Gubert, Fernanda; Monnerat, Gustavo; Silva dos Santos, Danúbia; Neiman, Gabriel; Leitão, Isabela C.; Barbosa, Raiana A. Q.; Coutinho, Jorge L.; Vaz, Isadora M.; dos Santos, Marcus N.; Borgonovo, Tamara; Cruz, Fernando E. S.; Miriuka, Santiago Gabriel; Medei, Emiliano H.; Campos de Carvalho, Antonio C.; Carvalho, Adriana B. (Nature Publishing Group, 2019-12-16)

Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC) offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The objective of this work was to study a type 2 ...

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