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Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness

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dc.contributor.author Sanz Perl, Yonatan
dc.contributor.author Pallavicini, Carla
dc.contributor.author Pérez Ipiña, Ignacio
dc.contributor.author Demertzi, Athena
dc.contributor.author Bonhomme, Vincent
dc.contributor.author Martial, Charlotte
dc.contributor.author Panda, Rajanikant
dc.contributor.author Annen, Jitka
dc.contributor.author Ibañez, Agustín
dc.contributor.author Kringelbach, Morten
dc.contributor.author Deco, Gustavo
dc.contributor.author Laufs, Helmut
dc.contributor.author Sitt, Jacobo D.
dc.contributor.author Laureys, Steven
dc.contributor.author Tagliazucchi, Enzo
dc.date.accessioned 2021-09-08T15:52:28Z
dc.date.available 2021-09-08T15:52:28Z
dc.date.issued 2021-07-27
dc.identifier.citation Sanz Perl Y, Pallavicini C, Pérez Ipiña I, Demertzi A, Bonhomme V, Martial C, Panda R, Annen J, Ibañez A, Kringelbach M, Deco G, Laufs H, Sitt J, Laureys S, Tagliazucchi E. Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness. PLoS Comput Biol. 2021 Jul 27;17(7):e1009139. doi: 10.1371/journal.pcbi.1009139 es_ES
dc.identifier.uri https://doi.org/10.1371/journal.pcbi.1009139
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/579
dc.description.abstract Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index to quantify the level of consciousness across these different states is regarded as a key problem both in basic and clinical neuroscience. We argue that this problem is ill-defined since such an index would not exhaust all the relevant information about a given state of consciousness. While the level of consciousness can be taken to describe the actual brain state, a complete characterization should also include its potential behavior against external perturbations. We developed and analyzed whole-brain computational models to show that the stability of conscious states provides information complementary to their similarity to conscious wakefulness. Our work leads to a novel methodological framework to sort out different brain states by their stability and reversibility, and illustrates its usefulness to dissociate between physiological (sleep), pathological (brain-injured patients), and pharmacologically-induced (anesthesia) loss of consciousness. es_ES
dc.language.iso eng es_ES
dc.publisher Public Library of Science es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Consciousness es_ES
dc.subject Estado de Conciencia es_ES
dc.subject Consciousness Monitors es_ES
dc.subject Monitores de Conciencia es_ES
dc.title Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Sanz Perl, Yonatan. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.description.fil Fil: Pallavicini, Carla. Fleni. Instituto de Neurociencias FLENI-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina.
dc.description.fil Fil: Pérez Ipiña, Ignacio. Fleni. Instituto de Neurociencias FLENI-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina.
dc.description.fil Fil: Demertzi, Athena. University of Liège; Bélgica.
dc.description.fil Fil: Bonhomme, Vincent. University of Liège; Bélgica.
dc.description.fil Fil: Martial, Charlotte. University of Liège; Bélgica.
dc.description.fil Fil: Panda, Rajanikant. University of Liège; Bélgica.
dc.description.fil Fil: Annen, Jitka. University of Liège; Bélgica.
dc.description.fil Fil: Ibañez, Agustín. Universidad de San Andrés; Argentina.
dc.description.fil Fil: Kringelbach, Morten. University of Oxford; Reino Unido.
dc.description.fil Fil: Deco, Gustavo. Universitat Pompeu Fabra; España.
dc.description.fil Fil: Laufs, Helmut. Goethe University; Alemania.
dc.description.fil Fil: Sitt, Jacobo D. Institut du Cerveau et de la Moelle épinière; Francia.
dc.description.fil Fil: Laureys, Steven. University of Liège; Bélgica.
dc.description.fil Fil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina.
dc.relation.ispartofVOLUME 17
dc.relation.ispartofNUMBER 7
dc.relation.ispartofPAGINATION e1009139
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY San Francisco
dc.relation.ispartofTITLE PLoS computational biology
dc.relation.ispartofISSN 1553-7358
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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