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Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry

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dc.contributor.author Lazow, Margot A.
dc.contributor.author Fuller, Christine
dc.contributor.author DeWire-Schottmiller, Mariko
dc.contributor.author Lane, Adam
dc.contributor.author Bandopadhayay, Pratiti
dc.contributor.author Bartels, Ute
dc.contributor.author Bouffet, Eric
dc.contributor.author Cheng, Sylvia
dc.contributor.author Cohen, Kenneth J.
dc.contributor.author Cooney, Tabitha M.
dc.contributor.author Coven, Scott L.
dc.contributor.author Dholaria, Hetal
dc.contributor.author Diez, Blanca
dc.contributor.author Dorris, Kathleen
dc.contributor.author El-Ayadi, Moatasem
dc.contributor.author El-Sheikh, Ayman
dc.contributor.author Fisher, Paul G.
dc.contributor.author Fonseca, Adriana
dc.contributor.author Garcia Lombardi, Mercedes
dc.contributor.author Sevlever, Gustavo Emilio
dc.date.accessioned 2021-11-03T17:35:39Z
dc.date.available 2021-11-03T17:35:39Z
dc.date.issued 2021-10-20
dc.identifier.citation Lazow MA, Fuller C, DeWire-Schottmiller M, Lane A, Bandopadhayay P, Bartels U, Bouffet E, Cheng S, Cohen KJ, Cooney TM, Coven SL, Dholaria H, Diez B, Dorris K, El-Ayadi M, El-Sheikh A, Fisher PG, Fonseca A, Lombardi MG, Greiner RJ, Goldman S, Gottardo N, Gururangan S, Hansford JR, Hassall T, Hawkins C, Kilburn L, Koschmann C, Leary SE, Ma J, Minturn JE, Monje-Deisseroth M, Packer R, Samson Y, Sandler ES, Sevlever GE, Tinkle CL, Tsui K, Wagner LM, Zaghloul M, Ziegler DS, Chaney B, Black K, Asher A, Drissi R, Fouladi M, Jones BV, Leach JL. Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry. Neuro Oncol. 2021 Oct 20:noab245. doi: 10.1093/neuonc/noab245 es_ES
dc.identifier.uri https://doi.org/10.1093/neuonc/noab245
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/615
dc.description.abstract Background Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential. Methods Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included non-pontine origin, <50% pontine involvement, focally exophytic morphology, sharply-defined margins, and/or marked diffusion restriction throughout. Results Among 286 patients with pathology from biopsy and/or autopsy, 23 (8%) had histologic diagnoses inconsistent with DIPG, most commonly non-diffuse low-grade gliomas and embryonal tumors. Among 569 patients with centrally-reviewed diagnostic MRIs, 40 (7%) were classified as non-DIPG, alternative diagnosis suspected. The combined analysis included 151 patients with both histopathology and centrally-reviewed MRI. Of 77 patients with imaging classified as characteristic of DIPG, 76 (99%) had histopathologic diagnoses consistent with DIPG (infiltrating grade II-IV gliomas). Of 57 patients classified as likely DIPG with some unusual imaging features, 55 (96%) had histopathologic diagnoses consistent with DIPG. Of 17 patients with imaging features suggestive of an alternative diagnosis, eight (47%) had histopathologic diagnoses inconsistent with DIPG (remaining patients were excluded due to non-pontine tumor origin). Association between central neuro-imaging review impression and histopathology was significant (p<0.001), and central neuro-imaging impression was prognostic of overall survival. Conclusions The accuracy and important role of central neuro-imaging review in confirming the diagnosis of DIPG is demonstrated. es_ES
dc.language.iso eng es_ES
dc.publisher Oxford es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Diffuse Intrinsic Pontine Glioma es_ES
dc.subject Glioma Pontino Intrínseco Difuso es_ES
dc.subject Neuroimaging es_ES
dc.subject Neuroimagen es_ES
dc.subject Brain Stem Neoplasms es_ES
dc.subject Neoplasias del Tronco Encefálico es_ES
dc.title Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Lazow, Margot A. Cincinnati Children's Hospital Medical Center; Estados Unidos.
dc.description.fil Fil: Fuller, Christine. Upstate Medical University; Estados Unidos.
dc.description.fil Fil: DeWire-Schottmiller, Mariko. Cincinnati Children's Hospital Medical Center; Estados Unidos.
dc.description.fil Fil: Lane, Adam. Cincinnati Children's Hospital Medical Center; Estados Unidos.
dc.description.fil Fil: Bandopadhayay, Pratiti. Harvard Cancer Center; Estados Unidos.
dc.description.fil Fil: Bartels, Ute. The Hospital for Sick Children; Estados Unidos.
dc.description.fil Fil: Bouffet, Eric. The Hospital for Sick Children; Estados Unidos.
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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