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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

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dc.contributor.author Cavanna, Federico
dc.contributor.author Muller, Stephanie
dc.contributor.author de la Fuente, Laura A.
dc.contributor.author Zamberlan, Federico
dc.contributor.author Palmucci, Matías
dc.contributor.author Janeckova, Lucie
dc.contributor.author Kuchar, Martin
dc.contributor.author Pallavicini, Carla
dc.date.accessioned 2022-08-22T15:06:42Z
dc.date.available 2022-08-22T15:06:42Z
dc.date.issued 2022-08-02
dc.identifier.citation Cavanna F, Muller S, de la Fuente LA, Zamberlan F, Palmucci M, Janeckova L, Kuchar M, Pallavicini C, Tagliazucchi E. Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study. Transl Psychiatry. 2022 Aug 2;12(1):307. doi: 10.1038/s41398-022-02039-0. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/652
dc.identifier.uri https://doi.org/10.1038/s41398-022-02039-0
dc.description.abstract The use of low sub-perceptual doses of psychedelics ("microdosing") has gained popularity in recent years. Although anecdotal reports claim multiple benefits associated with this practice, the lack of placebo-controlled studies severely limits our knowledge of microdosing and its effects. Moreover, research conducted in standard laboratory settings could fail to capture the motivation of individuals engaged or planning to engage in microdosing protocols, thus underestimating the likelihood of positive effects on creativity and cognitive function. We recruited 34 individuals starting to microdose with psilocybin mushrooms (Psilocybe cubensis), one of the materials most frequently used for this purpose. Following a double-blind placebo-controlled experimental design, we investigated the acute and short-term effects of 0.5 g of dried mushrooms on subjective experience, behavior, creativity (divergent and convergent thinking), perception, cognition, and brain activity. The reported acute effects were significantly more intense for the active dose compared to the placebo, but only for participants who correctly identified their experimental condition. These changes were accompanied by reduced EEG power in the theta band, together with preserved levels of Lempel-Ziv broadband signal complexity. For all other measurements there was no effect of microdosing except for few small changes towards cognitive impairment. According to our findings, low doses of psilocybin mushrooms can result in noticeable subjective effects and altered EEG rhythms, but without evidence to support enhanced well-being, creativity and cognitive function. We conclude that expectation underlies at least some of the anecdotal benefits attributed to microdosing with psilocybin mushrooms. es_ES
dc.language.iso eng es_ES
dc.publisher Nature Pub. Group es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alucinógenos es_ES
dc.subject Hallucinogens es_ES
dc.subject Psychiatry
dc.title Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Cavanna, Federico. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina. Fleni. Instituto de Neurociencias FLENI-CONICET; Argentina.
dc.description.fil Fil: Muller, Stephanie. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina.
dc.description.fil Fil: de la Fuente, Laura A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina. Institute of Cognitive and Translational Neuroscience; Argentina.
dc.description.fil Fil: Zamberlan, Federico. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina. Tilburg University. Department of Cognitive Science and Artificial Intelligence; Países Bajos.
dc.description.fil Fil: Palmucci, Matías. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina.
dc.description.fil Fil: Janeckova, Lucie. University of Chemistry and Technology Prague. Department of Chemistry of Natural Compounds. Forensic Laboratory of Biologically Active Substances; República Checa.
dc.description.fil Fil: Kuchar, Martine. University of Chemistry and Technology Prague. Department of Chemistry of Natural Compounds. Forensic Laboratory of Biologically Active Substances; República Checa. National Institute of Mental Health, Klecany. Department of Experimental Neurobiology; República Checa.
dc.description.fil Fil: Pallavicini, Carla. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Instituto de Física de Buenos Aires; Argentina. Fleni. Instituto de Neurociencias FLENI-CONICET; Argentina.
dc.relation.ispartofVOLUME 12
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 307
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Translational psychiatry
dc.relation.ispartofISSN 2158-3188
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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