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Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma

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dc.contributor.author Videla Richardson, Guillermo Agustín
dc.contributor.author Morris Hanon, Olivia
dc.contributor.author Torres, Nicolás I.
dc.contributor.author Esquivel, Myrian Inés
dc.contributor.author Vera, Mariana Belén
dc.contributor.author Ripari, Luisina Belén
dc.contributor.author Croci, Diego O.
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Rabinovich, Gabriel A.
dc.date.accessioned 2022-09-14T17:21:29Z
dc.date.available 2022-09-14T17:21:29Z
dc.date.issued 2021-12-28
dc.identifier.citation Videla-Richardson, G.A., Morris-Hanon, O., Torres, N.I., Esquivel, M.I., Vera, M.B., Ripari, L.B., Croci, D.O., Sevlever, G.E., Rabinovich, G.A., 2021. Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma. Int J Mol Sci 23, 316. Doi: 10.3390/ijms23010316 es_ES
dc.identifier.uri https://doi.org/10.3390/ijms23010316
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/670
dc.description.abstract Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the most common and aggressive brain tumor in the adult population, urging identification of new rational therapeutic targets. Galectins, a family of glycan-binding proteins, are highly expressed in the tumor microenvironment (TME) and delineate prognosis and clinical outcome in patients with GBM. These endogenous lectins play key roles in different hallmarks of cancer by modulating tumor cell proliferation, oncogenic signaling, migration, vascularization and immunity. Additionally, they have emerged as mediators of resistance to different anticancer treatments, including chemotherapy, radiotherapy, immunotherapy, and antiangiogenic therapy. Particularly in GBM, galectins control tumor cell transformation and proliferation, reprogram tumor cell migration and invasion, promote vascularization, modulate cell death pathways, and shape the tumor-immune landscape by targeting myeloid, natural killer (NK), and CD8+ T cell compartments. Here, we discuss the role of galectins, particularly galectin-1, -3, -8, and -9, as emerging glyco-checkpoints that control different mechanisms associated with GBM progression, and discuss possible therapeutic opportunities based on inhibition of galectin-driven circuits, either alone or in combination with other treatment modalities. es_ES
dc.language.iso eng es_ES
dc.publisher Molecular Diversity Preservation International es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Galectins es_ES
dc.subject Galectinas es_ES
dc.subject Glioblastoma es_ES
dc.title Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Videla Richardson, Guillermo Agustín. Fleni. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Morris Hanon, Olivia. Fleni. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Torres, Nicolás I. Instituto de Biología y Medicina Experimental; Argentina.
dc.description.fil Fil: Esquivel, Myrian Inés. Fleni. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Vera, Mariana Belén. Fleni. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Ripari, Luisina Belén. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Croci, Diego O. Instituto de Histología y Embriología de Mendoza; Argentina.
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Laboratorio de Investigación Aplicada en Neurociencias; Argentina.
dc.description.fil Fil: Rabinovich, Gabriel A. Instituto de Biología y Medicina Experimental; Argentina.
dc.relation.ispartofVOLUME 23
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 316
dc.relation.ispartofCOUNTRY Suiza
dc.relation.ispartofCITY Basilea
dc.relation.ispartofTITLE International journal of molecular sciences
dc.relation.ispartofISSN 1422-0067
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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