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Final results of the Choroid Plexus Tumor study CPT-SIOP-2000

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dc.contributor.author Wolff, Johannes E.
dc.contributor.author Van Gool, Stefaan W.
dc.contributor.author Kutluk, Tezer
dc.contributor.author Diez, Blanca
dc.contributor.author Kebudi, Rejin
dc.contributor.author Timmermann, Beate
dc.contributor.author Garami, Miklos
dc.contributor.author Sterba, Jaroslav
dc.contributor.author Fuller, Gregory N.
dc.contributor.author Bison, Brigitte
dc.contributor.author Kordes, Uwe R.
dc.date.accessioned 2022-10-24T16:22:46Z
dc.date.available 2022-10-24T16:22:46Z
dc.date.issued 2022-02
dc.identifier.citation Wolff JE, Van Gool SW, Kutluk T, Diez B, Kebudi R, Timmermann B, Garami M, Sterba J, Fuller GN, Bison B, Kordes UR. Final results of the Choroid Plexus Tumor study CPT-SIOP-2000. J Neurooncol. 2022 Feb;156(3):599-613. doi: 10.1007/s11060-021-03942-0. Epub 2022 Jan 8. es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/707
dc.identifier.uri https://doi.org/10.1007/s11060-021-03942-0
dc.description.abstract Introduction: Standards for chemotherapy against choroid plexus tumors (CPT) have not yet been established. Methods: CPT-SIOP-2000 (NCT00500890) was an international registry for all CPT nesting a chemotherapy randomization for high-risk CPT with Carboplatin/Etoposide/Vincristine (CarbEV) versus Cyclophosphamide/Etoposide/Vincristine (CycEV). Patients older than three years were recommended to receive irradiation: focal fields for non-metastatic CPC, incompletely resected atypical choroid plexus papilloma (APP) or metastatic choroid plexus papilloma (CPP); craniospinal fields for metastatic CPC/APP and non-responsive CPC. High risk was defined as choroid plexus carcinoma (CPC), incompletely resected APP, and all metastatic CPT. From 2000 until 2010, 158 CPT patients from 23 countries were enrolled. Results: For randomized CPC, the 5/10 year progression free survival (PFS) of patients on CarbEV (n = 20) were 62%/47%, respectively, compared to 27%/18%, on CycEV (n = 15), (intention-to-treat, HR 2.6, p = 0.032). Within the registry, histological grading was the most influential prognostic factor: for CPP (n = 55) the 5/10 year overall survival (OS) and the event free survival (EFS) probabilities were 100%/97% and 92%/92%, respectively; for APP (n = 49) 96%/96% and 76%/76%, respectively; and for CPC (n = 54) 65%/51% and 41%/39%, respectively. Without irradiation, 12 out of 33 patients with CPC younger than three years were alive for a median of 8.52 years. Extent of surgery and metastases were not independent prognosticators. Conclusions: Chemotherapy for Choroid Plexus Carcinoma is feasible and effective. CarbEV is superior to CycEV. A subset of CPC can be cured without irradiation. es_ES
dc.language.iso eng es_ES
dc.publisher Springer es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Chemotherapy es_ES
dc.subject Quimioterapia es_ES
dc.subject Neoplasias del Plexo Coroideo es_ES
dc.subject Choroid Plexus Neoplasms es_ES
dc.title Final results of the Choroid Plexus Tumor study CPT-SIOP-2000 es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Diez, Blanca. Fleni. Departamento de Neurología. Servicio de Neurooncología; Argentina.
dc.description.fil Fil: Wolff, Johannes E. University of Regensburg; Alemania.
dc.description.fil Fil: Van Gool, Stefaan W. IOZK Immune Oncological Centre Cologne; Alemania.
dc.description.fil Fil: Kutluk, Tezer. Hacettepe University Medical School and Cancer Institute. Department of Pediatric Oncology; Turquía.
dc.description.fil Fil: Kebudi, Rejin. Istanbul University. Oncology Institute. Pediatric Hematology-Oncology; Turquía.
dc.description.fil Fil: Timmermann, Beate. German Cancer Consortium; Alemania. West German Proton Therapy Centre Essen; Alemania. University Hospital Essen. Department of Particle Therapy; Alemania.
dc.description.fil Fil: Garami, Miklos. Semmelweis University. Department of Pediatric; Hungría.
dc.description.fil Fil: Sterba, Jaroslav. Masaryk University. University Hospital Brno and Faculty of Medicine. Department of Pediatric Oncology; República Checa. St. Anne's University Hospital. International Clinical Research Center; República Checa.
dc.description.fil Fil: Fuller, Gregory N. MD Anderson Cancer Center. Departments of Neuropathology and Neuroradiology; Estados Unidos.
dc.description.fil Fil: Bison, Brigitte. University Hospital of Augsburg. Departments of Neuroradiology; Alemania.
dc.description.fil Fil: Kordes, Uwe R. University Medical Center Hamburg. Department of Pediatric Hematology and Oncology; Alemania.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Journal of neuro-oncology
dc.relation.ispartofISSN 1573-7373
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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