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How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson's disease?

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dc.contributor.author Rossi, Malco Damián
dc.contributor.author Perez Lloret, Santiago
dc.contributor.author Merello, Marcelo
dc.date.accessioned 2022-11-07T16:26:21Z
dc.date.available 2022-11-07T16:26:21Z
dc.date.issued 2021-10-22
dc.identifier.citation Rossi MS, Perez Lloret S, Merello M. How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson's disease? Parkinsonism Relat Disord. 2021 Oct 19;92:53-58. doi: 10.1016/j.parkreldis.2021.10.016 es_ES
dc.identifier.uri https://doi.org/10.1016/j.parkreldis.2021.10.016
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/710
dc.description.abstract Introduction: The implementation of accepted clinical diagnostic criteria has improved the accuracy of a clinical diagnosis of Parkinson's disease (PD). Time frames of 3-10 years have been empirically proposed to reach a diagnosis of clinically established PD. Methods: We explored the time to a Final Clinical Diagnosis (FCD) and the factors that predict faster diagnoses in patients presenting with parkinsonism and/or tremor between 2009 and 2015 at our tertiary center. All patients underwent a standardized workout process to reach a FCD, which included an acute levodopa challenge (LDC) after the first visit. Results: Among the 326 patients included, 215 (66%) received a FCD within the first six months after the LDC. A FCD was reached in 95% and 100% of patients in 33 and 108 months, respectively. PD was the FCD in 196 patients (60.1%). The FCD was reached faster in patients with a positive response to levodopa and when the FCD was PD. Conclusion: The time needed to reach a final diagnosis in the clinical setting was 2.75 years in 95% of patients presenting initially with parkinsonism and/or tremor. Patients with positive responses to levodopa at the LDC, benefited from shorter delays until the FCD. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Parkinson Disease es_ES
dc.subject Enfermedad de Parkinson es_ES
dc.subject Symptom Assessment es_ES
dc.subject Evaluación de Síntomas es_ES
dc.title How much time is needed in clinical practice to reach a diagnosis of clinically established Parkinson's disease? es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Rossi, Malco Damián. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina.
dc.description.fil Fil: Perez Lloret, Santiago. Universidad Católica de Buenos Aires; Argentina.
dc.description.fil Fil: Merello, Marcelo. Fleni. Departamento de Neurología. Servicio de Movimientos Anormales; Argentina.
dc.relation.ispartofVOLUME 92
dc.relation.ispartofPAGINATION 53-58
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Oxford
dc.relation.ispartofTITLE Parkinsonism & related disorders
dc.relation.ispartofISSN 1873-5126
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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