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Browsing INEU.artículos by Author "Hassenstab, Jason"

Browsing INEU.artículos by Author "Hassenstab, Jason"

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  • Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome 
    Gorijala, Priyanka; Aslam, M. Muaaz; Dang, Lam-Ha T.; Xicota, L.; Fernández, María V.; Sung, Yun Ju; Fan, Kang-Hsien; Feingold, Eleanor; Surace, Ezequiel Ignacio; Chhatwal, Jasmeer P.; Hom, Christy L.; Dominantly Inherited Alzheimer Network; NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigators; Hartley, Sigan L.; Hassenstab, Jason; Perrin, Richard J.; Mapstone, Mark; Zaman, Shahid H.; Ances, Beau M.; Kamboh, M. Ilyas; Lee, Joseph H.; Cruchaga, Carlos (John Wiley & Sons, 2023-10-19)
    Introduction: This study aimed to investigate the influence of the overall Alzheimer's disease (AD) genetic architecture on Down syndrome (DS) status, cognitive measures, and cerebrospinal fluid (CSF) biomarkers. Methods: ...
  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study 
    O'Connor, Antoinette; Rice, Helen; Barnes, Josephine; Ryan, Natalie S.; Liu, Kathy Y.; Allegri, Ricardo Francisco; Berman, Sarah B.; Ringman, John M.; Cruchaga, Carlos; Farlow, Martin R.; Hassenstab, Jason; Lee, Jae-Hong; Perrin, Richard J.; Xiong, Chengjie; Gordon, Brian A.; Levey, Allan I.; Goate, Alison M.; Graff-Radford, Neill R.; Levin, Johannes; Dominantly Inherited Alzheimer Network (BMJ Publishing Group, 2022-12-15)
  • Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 
    Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)
    Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...

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