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The role of microfluidics and 3D-bioprinting in the future of exosome therapy

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dc.contributor.author Amondarain, Mikele
dc.contributor.author Gallego, Idoia
dc.contributor.author Puras, Gustavo
dc.contributor.author Saenz-Del-Burgo, Laura
dc.contributor.author Luzzani, Carlos Daniel
dc.contributor.author Pedraz, José Luis
dc.date.accessioned 2023-12-18T16:13:28Z
dc.date.available 2023-12-18T16:13:28Z
dc.date.issued 2023-06-09
dc.identifier.citation Amondarain M, Gallego I, Puras G, Saenz-Del-Burgo L, Luzzani CD, Pedraz JL. The role of microfluidics and 3D-bioprinting in the future of exosome therapy. Trends Biotechnol. 2023 Nov;41(11):1343-1359. doi: 10.1016/j.tibtech.2023.05.006 es_ES
dc.identifier.uri https://doi.org/10.1016/j.tibtech.2023.05.006
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/918
dc.description.abstract Exosome-based strategies constitute a promising tool for therapeutics, avoiding potential immunogenic and tumorigenic side-effects of cell therapies. However, the collection of a suitable exosome pool, and the need for high doses with conventional administration approaches, hamper their clinical translation. To overcome these challenges, versatile exosome collection strategies together with advanced delivery platforms may represent major progress in this field. Microfluidics enables large-scale gathering of both natural and synthetic exosomes for their implementation into bioinks, while 3D-bioprinting holds great promise in regenerative medicine with the use of exosome-loaded scaffolds that mimic the target tissue with controlled pharmacokinetics and pharmacodynamics. Hence, the combination of both strategies might become the key for the translation of exosome therapies to clinical practice. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.subject Bioprinting es_ES
dc.subject Bioimpresión es_ES
dc.subject Exosomes es_ES
dc.subject Exosomas es_ES
dc.subject Microfluidics es_ES
dc.subject Microfluídica es_ES
dc.title The role of microfluidics and 3D-bioprinting in the future of exosome therapy es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Amondarain, Mikele. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Luzzani, Carlos Daniel. Fleni. Instituto de Neurociencias FLENI-CONICET. Laboratorio de Investigación Aplicada a las Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.relation.ispartofVOLUME 41
dc.relation.ispartofNUMBER 11
dc.relation.ispartofPAGINATION 1343-1359
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Barking
dc.relation.ispartofTITLE Trends in biotechnology
dc.relation.ispartofISSN 1879-3096
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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