Repositorio Institucional FLENI: Recent submissions

  • Priorities to reduce the burden of stroke in Latin American countries 
    Ouriques Martins, Sheila C.; Sacks, Claudio; Hacke, Werner; Brainin, Michael; de Assis Figueiredo, Francisco; Marques Pontes-Neto, Octávio; Lavados, Pablo M.; Marinho, Maria F.; Hoppe Wiegering, Arnold; Vaca McGhie, Diana; Cruz-Flores, Salvador; Ameriso, Sebastián Francisco; Camargo Villareal, Walter M.; Durán, Juan Carlos; Fogolin Passos, José E.; Gomes Nogueira, Raul; Freitas de Carvalho, João J.; Sampaio Silva, Gisele; Cabral Moro, Carla H.; Oliveira-Filho, Jamary (Lancet Pub. Group, 2019-04-24)
    The large and increasing burden of stroke in Latin American countries, and the need to meet the UN and WHO requirements for reducing the burden from non-communicable disorders (including stroke), brought together stroke ...
  • Seizures as an early symptom of autosomal dominant Alzheimer's disease 
    Vöglein, Jonathan; Noachtar, Soheyl; McDade, Eric; Quaid, Kimberly A.; Salloway, Stephen; Ghetti, Bernardino; Noble, James M.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Mori, Hiroshi; Fox, Nick C.; Allegri, Ricardo Francisco; Masters, Colin L.; Buckles, Virginia; Ringman, John M.; Rossor, Martin N.; Schofield, Peter R.; Sperling, Reisa; Jucker, Mathias; Dominantly Inherited Alzheimer Network (Elsevier, 2018-12-05)
    Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status ...
  • Branch atheromatous disease diagnosed as embolic stroke of undetermined source: A sub-analysis of NAVIGATE ESUS 
    Uchiyama, Shinichiro; Toyoda, Kazunori; Kitagawa, Kazuo; Okada, Yasushi; Ameriso, Sebastián Francisco; Mundl, Hardi; Berkowitz, Scott D.; Yamada, Takashi; Liu, Yan Yun; Hart, Robert G.; NAVIGATE ESUS Investigators (Sage, 2019-05-17)
    Background: Branch atheromatous disease (BAD) is distinctive from large and small arterial diseases, which is single subcortical infarction larger than lacunar stroke in the territories of deep perforators without relevant ...
  • SWAN-Venule: An Optimized MRI Technique to Detect the Central Vein Sign in MS Plaques 
    Gaitán, María Inés; Yáñez, Paulina; Paday Formenti, María Emilia; Calandri, Ismael Luis; Figueiredo, E.; Sati, P.; Correale, Jorge (Williams & Wilkins, 2020-03)
    Background and purpose: Multiple sclerosis lesions develop around small veins that are radiologically described as the so-called central vein sign. With 7T MR imaging and magnetic susceptibility-based sequences, the central ...
  • Management of Advanced Therapies in Parkinson’s Disease Patients in Times of Humanitarian Crisis: The COVID-19 Experience 
    Fasano, Alfonso; Antonini, Angelo; Katzenschlager, Regina; Krack, Paul; Odin, Per; Evans, Andrew H.; Foltynie, Thomas; Volkmann, Jens; Merello, Marcelo (Wiley, 2020-05-04)
    Background: Although the COVID-19 pandemic is affecting a relatively small proportion of the global population, its effects have already reached everyone. The pandemic has the potential to differentially disadvantage ...
  • Consenso sobre el uso de anticuerpos monoclonales en la migraña en Argentina 
    Doctorovich, Eduardo D.; Martín-Bertuzzi, Fiorella; Goicochea, María Teresa; Miranda, Silvina; Figuerola, María L.; Schubaroff, Pablo A.; Buonanotte, Federico; Rocchi, Viviana; Rua, Isabel; Bruera, Osvaldo; Giglio, Jorge; De Paz, José J.; Pelli-Noble, Raúl; Arago, Laura; Burgos, Marcos; Ayala, Leonardo S.; Davidow, Laura; Bonamico, Lucas (Viguera Editores S.L.U., 2020-02-16)
    Introducción. La migraña es un trastorno muy prevalente que se estima que afecta a alrededor del 15% de los sujetos adultos. Durante los últimos años, se ha evaluado la eficacia y la seguridad de los anticuerpos monoclonales ...
  • Tubular resection of a deep-seated motor cortex lesion: an illustrative clinical case 
    Revuelta Barbero, Juan M.; Yanez-Siller, Juan C.; Villalonga, Juan Francisco; Prevedello, Daniel M. (Minerva Medica, 2018-03-26)
    Resumen no disponible
  • Spike-and-wave epileptiform discharge pattern detection based on Kendall's Tau-b coefficient 
    Quintero Rincón, Antonio; Carenzo, Catalina; Ems, Joaquín; Hirschson, Lourdes; Muro, Valeria L.; D'Giano, Carlos ("Iuliu Haţieganu" Publishing House, 2019-03-30)
    Epilepsy is an important public health issue. An appropriate epileptiform discharge pattern detection of this neurological disease is a typical problem in biomedical engineering. In this paper, a new method is proposed for ...
  • A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit 
    Kotfis, Katarzyna; Wittebole, Xavier; Jaschinski, Ulrich; Solé-Violán, Jordi; Kashyap, Rahul; Leone, Marc; Nanchal, Rahul; Fontes, Luis E.; Sakr, Yasser; Vincent, Jean-Louis; ICON Investigators (Elsevier, 2019-02-13)
    Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult ...
  • The role of infections in multiple sclerosis 
    Marrodán, Mariano; Alessandro, Lucas; Farez, Mauricio Franco; Correale, Jorge (Sage, 2019-01-14)
    Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune diseases, may be triggered by microbial infections. Pathogens associated with development or exacerbation of MS include bacteria, such ...
  • Estudio epidemiológico de sepsis grave pediátrica en la República Argentina 
    Jabornisky, Roberto; Sáenz, Silvia S.; Capocasa, Patricia; Jaen, Roxana; Moreno, Rodolfo P.; Landry, Luis; Rufach, Daniel; Santos, Silvia N.; Berrueta, Mabel; Carcillo, Joseph; Vassallo, Juan Carlos; Grupo de Investigación Clínica y Epidemiológica en Terapia Intensiva Pediátrica de la Sociedad Argentina de Pediatría (Sociedad Argentina de Pediatría, 2019-06)
    Introduction: Severe sepsis (SS) is one of the leading causes of pediatric mortality in Argentina. The objective was to describe the epidemiological characteristics and to analyze risk factors associated with mortality ...
  • Stroke Epidemiology in Argentina. Design of a Population-Based Study in General Villegas (EstEPA) 
    Pujol Lereis, Virginia Andrea; Melcon, Mario O.; Hawkes, Maximiliano Alberto; Gómez Schneider, Maia Macarena; Dossi, Daiana Elizabeth; Alet, Matías Javier; Povedano, Guillermo Pablo; Gonzalez, Claudio D.; Ameriso, Sebastián Francisco (Elsevier, 2018-10-04)
    Background: Epidemiological data on stroke is scarce in Latin America. Estudio Epidemiológico Poblacional sobre Accidente Cerebrovascular (EstEPA) is a population-based program planned to assess prevalence, incidence, ...
  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease 
    Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber-Sultan, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph N.; Schofield, Peter R.; Rossor, Martin N.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-01-21)
    Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • Structural brain abnormalities in schizophrenia in adverse environments: examining the effect of poverty and violence in six latin american cities 
    Crossley, Nicolas; Zugman, Andre; Reyes-Madrigal, Francisco; Czepielewski, Leticia; Castro, Mariana Nair; Diaz-Zuluaga, Ana María; Pineda-Zapata, Julián; Reckziegel, Ramiro; Gadelha, Ary; Jackowski, Andrea; Noto, Cristiano; Alliende Serra, Luz Maria; Iruretagoyena, Bárbara; Ossandon, Tomas; Ramirez-Mahaluf, Juan Pablo; Castañeda, Carmen Paz; Gonzalez-Valderrama, Alfonso; Nachar, Rubén; León-Ortiz, Pablo; Undurraga, Juan; Lopez-Jaramillo, Carlos; Guinjoan, Salvador Martín; Gama, Clarissa; De la Fuente-Sandoval, Camilo; Bressan, Rodrigo (Oxford University Press, 2020-04)
    Background Social and environmental factors such as poverty or violence, modulate the risk and course of schizophrenia, but how they affect the brain in patients with psychosis remains unclear. We here studied how they ...
  • What is the role of axonal ion channels in multiple sclerosis? 
    Correale, Jorge; Marrodán, Mariano; Benarroch, Eduardo E. (Lippincott Williams & Wilkins, 2020-07-21)
    Resumen no disponible
  • Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries 
    Hsia, Yingfen; Lee, Brian L.; Versporten, Ann; Yang, Yonghong; Bielicki, Julia; Jackson, Charlotte; Newland, Jason; Goossens, Herman; Magrini, Nicola; Sharland, Mike; GARPEC network; SHARPS collaborative; Global-PPS network (Elsevier, 2019-06-11)
    Background Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification ...
  • An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations 
    Dube, Umber; Del-Aguila, Jorge L.; Li, Zeran; Budde, John P.; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L.; Lee, Jae-Hong; Graff-Radford, Neill R.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-10-07)
    Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and ...
  • Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR‐Preserved Trial 
    Anker, Stefan D.; Butler, Javed; Filippatos, Gerasimos; Waheed, Jamal; Salsali, Afshin; Schnee, Janet; Kimura, Karen; Zeller, Cordula; Jyothis, George; Brueckmann, Martina; Zannad, Faiez; Packer, Milton; EMPEROR-Preserved Trial Committees and Investigators (Wiley, 2019-09-16)
    Background: The principal biological processes that characterize heart failure with a preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue accumulation, coronary microcirculatory ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martin, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...

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