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Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings.

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dc.contributor.author Pestchanker, Claudia
dc.contributor.author Bertado Cortez, Brenda
dc.contributor.author Lana Peixoto, Marco A.
dc.contributor.author Gortari, José Ignacio
dc.contributor.author Castro Suarez, Sheila
dc.contributor.author Caparo Zamalloa, César
dc.contributor.author Galiana, Graciana Lourdes
dc.contributor.author Peñalver, Francisco
dc.contributor.author Daccach Marques, Vanessa
dc.contributor.author Messias, Katharina
dc.contributor.author Galleguillos Goiry, Lorna
dc.contributor.author García, Fernando
dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Liwacki, Susana
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Vrech, Carlos
dc.contributor.author Deri, Norma
dc.contributor.author Leguizamon, Felisa
dc.contributor.author Tavolini, Darío
dc.contributor.author Mainella, Carolina
dc.contributor.author Zanga, Gisela
dc.contributor.author Alonso Serena, Marina
dc.contributor.author Ciampi, Ethel
dc.contributor.author Herval Ribeiro Soares Neto, Herval
dc.contributor.author López, Pablo Adrián
dc.contributor.author Carnero Contentti, Edgar
dc.date.accessioned 2024-05-14T12:17:14Z
dc.date.available 2024-05-14T12:17:14Z
dc.date.issued 2024-03-17
dc.identifier.citation Pestchanker C, Bertado Cortez B, Lana Peixoto MA, Gortari JI, Castro Suarez S, Caparo Zamalloa C, Galiana G, Peñalver F, Daccach Marques V, Messias K, Galleguillos L, García F, Rojas JI, Patrucco L, Cristiano E, Tkachuk V, Liwacki S, Correale J, Marrodan M, Ysraelit MC, Vrech C, Deri N, Leguizamon F, Tavolini D, Mainella C, Zanga G, Alonso Serena M, Ciampi E, Neto HRS, Lopez P, Carnero Contentti E. Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings. J Neurol. 2024 Apr 17. doi: 10.1007/s00415-024-12371-8. Epub ahead of print. es_ES
dc.identifier.uri https://doi.org/10.1007/s00415-024-12371-8
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1109
dc.description.abstract Introduction: We aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory activity and prognostic factors of APS severity in a real-world setting. Methods: We conducted a retrospective study on a cohort of Latin American (LATAM) NMOSD patients who had experienced APS during their follow-up. Patients from Mexico, Peru, Brazil, Colombia, Panama, Chile and Argentina patients who met 2015 NMOSD criteria were included. We evaluated data on symptom type (nausea, vomiting and/or hiccups), frequency, duration, severity (measured by APS severity scale), association with other NMOSD core relapses, and acute treatments (symptomatic and immunotherapy or plasmapheresis). Logistic regression was conducted to evaluate factors associated with APS severity (vs. mild-moderate). Results: Out of 631 NMOSD patients, 116 (18.3%) developed APS during their follow-up. The most common APS phenotype was severe. Inflammatory activity (i.e., relapses) significantly decreased after the onset of APS. Half of the patients experienced isolated APS with a median duration of 10 days, and the most frequently used acute treatment was IV steroids. All three symptoms were present in 44.6% of the patients. APS symptoms resolved following immunotherapy. Logistic regression did not identify independent factors associated with the severity of APS. Conclusions: Our findings indicate that 18.3% of NMOSD patients developed APS during the follow-up period, with most patients fulfilling criteria for severe APS. The inflammatory activity decreased after the onset of APS compared to the previous year. es_ES
dc.language.iso eng es_ES
dc.publisher Springer-Verlag es_ES
dc.subject Neuromielitis Óptica es_ES
dc.subject Neuromyelitis Optica es_ES
dc.subject América Latina es_ES
dc.subject Latin America es_ES
dc.title Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings. es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Marrodan, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Journal of neurology
dc.relation.ispartofISSN 1432-1459
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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