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Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study

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dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author Lopez, Pablo A.
dc.contributor.author Pettinicchi, Juan Pablo
dc.contributor.author Miguez, Jimena
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Liwacki, Susana
dc.contributor.author Tkachuk, Verónica
dc.contributor.author Balbuena, María Eugenia
dc.contributor.author Vrech, Carlos
dc.contributor.author Deri, Norma
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Leguizamón, Felisa
dc.contributor.author Luetic, Geraldine
dc.contributor.author Tavolini, Darío
dc.contributor.author Mainella, Carolina
dc.contributor.author Zanga, Gisela
dc.contributor.author Burgos, Marcos
dc.contributor.author Hryb, Javier
dc.contributor.author Barboza, Andrés
dc.contributor.author Lazaro, Luciana
dc.contributor.author Alonso, Ricardo
dc.contributor.author Fernández Liguori, Nora
dc.contributor.author Nadur, Débora
dc.contributor.author Alonso Serena, Marina
dc.contributor.author Caride, Alejandro
dc.contributor.author Rojas, Juan I.
dc.date.accessioned 2024-07-22T12:47:37Z
dc.date.available 2024-07-22T12:47:37Z
dc.date.issued 2024-07-15
dc.identifier.citation Carnero Contentti E, Lopez PA, Pettinicchi JP, Miguez J, Patrucco L, Cristiano E, Liwacki S, Tkachuk V, Balbuena ME, Vrech C, Deri N, Correale J, Marrodan M, Ysrraelit MC, Leguizamon F, Luetic G, Tavolini D, Mainella C, Zanga G, Burgos M, Hryb J, Barboza A, Lazaro L, Alonso R, Fernández Liguori N, Nadur D, Alonso Serena M, Caride A, Rojas JI. Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study. J Neurol Sci. 2024 Jul 15;462:123099. doi: 10.1016/j.jns.2024.123099. Epub 2024 Jun 14. es_ES
dc.identifier.uri https://doi.org/10.1016/j.jns.2024.123099
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1163
dc.description.abstract We aimed to assess the treatment strategies utilized in patients with neuromyelitis optica spectrum disorder (NMOSD) experiencing relapses, including their frequency, types, and response after 6 months based on the Expanded Disability Status Scale (EDSS) score. Methods: We conducted a retrospective study involving NMOSD patients from the Argentinean MS and NMOSD registry (RelevarEM, NCT03375177). Treatment response at 6 months was categorized as "good" if the EDSS score decreased by ≥1 point after a nadir EDSS score ≤ 3, or by ≥2 points after a nadir EDSS score > 3, "poor" if the EDSS score decrease was slighter, and as "absent" if the EDSS score remained unchanged or worsened. Results: We included 120 NMOSD patients (seropositive N = 75), who experienced 250 NMOSD-related relapses and received 248 treatments. At 6 months, complete recovery was achieved in 70/98 (71.4%) and 15/19 (79%) patients, respectively. Predictors of a "good" response in our regression model were a younger age at disease onset (OR:3.54, CI95% 2.45-5.01, p < 0.0001) and a short delay from onset of relapse to treatment initiation (OR:1.56, CI95% 1.22-2.13, p = 0.004). Conclusions: Approximately two-thirds of patients experienced complete recovery, and younger age and a short delay to start treatment were independent predictors of a "good" response. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier es_ES
dc.subject Neuromielitis Óptica es_ES
dc.subject Neuromyelitis Optica es_ES
dc.subject Pronóstico es_ES
dc.subject Prognosis es_ES
dc.subject Terapéutica es_ES
dc.subject Therapeutics es_ES
dc.title Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 462
dc.relation.ispartofPAGINATION 123099
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Ámsterdam
dc.relation.ispartofTITLE Journal of the neurological sciences
dc.relation.ispartofISSN 1878-5883
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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