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Human chorionic gonadotropin regulates cytokine production by lymphocytes from patients with multiple sclerosis

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dc.contributor.author Juriol, Lorena
dc.contributor.author Valeff, Natalín
dc.contributor.author Dibo, Marcos
dc.contributor.author Ventimiglia, María Silvia
dc.contributor.author Correale, Jorge
dc.contributor.author Jensen, Federico
dc.date.accessioned 2024-07-23T14:52:51Z
dc.date.available 2024-07-23T14:52:51Z
dc.date.issued 2024-06-12
dc.identifier.citation Juriol L, Valeff N, Dibo M, Ventimiglia MS, Correale J, Jensen F. Human chorionic gonadotropin regulates cytokine production by lymphocytes from patients with multiple sclerosis. J Reprod Immunol. 2024 Jun 12;164:104280. doi: 10.1016/j.jri.2024.104280. es_ES
dc.identifier.uri https://doi.org/10.1016/j.jri.2024.104280
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1172
dc.description.abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults, predominantly females. This was partially attributed to sex differences in immunity, which are influenced by changes in sex hormones occurring during women's life, among other factors. Furthermore, MS patients experience significant improvement in their symptoms during pregnancy when levels of female sex-hormones significantly increase. This phenomenon was attributed to immune adaptations occurring during gestation which are regulated by paternal antigens and sex hormones. The human chorionic gonadotropin (hCG) was shown to have strong immunosuppressive abilities. We aimed to analyze here the capacity of the hCG to regulate pro- and anti-inflammatory cytokine production by PBMC from MS patients. PBMC isolated from 17 MS patients receiving IFNβ1a treatment were cultured with or without recombinant or urinary hCG. Cytokine production in the supernatants was assessed using a CBA array and cytokine production by lymphocytes and expression of co-stimulatory molecules in B-lymphocytes were evaluated by flow cytometry. hCG reduced the production of TNF by PBMC from MS patients while lowering the percentages of TNF producing T cells and diminishing the production of TNF by B cells. hCG significantly boosted the production of IL-10 by regulatory T cells and CD19high B cells from MS patients. Furthermore, hCG treatment lowered the percentages of CD80+CD86+ expressing B cells within PBMC from MS patients. Overall, our results described a novel and not yet explored mechanisms of action of hCG in the context of MS. es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier/North-Holland Biomedical Press es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Gonadotropina Coriónica es_ES
dc.subject Chorionic Gonadotropin es_ES
dc.subject Citocinas es_ES
dc.subject Cytokines es_ES
dc.subject Pregnancy es_ES
dc.subject Embarazo es_ES
dc.subject Medicina Reproductiva
dc.subject Reproductive Medicine
dc.title Human chorionic gonadotropin regulates cytokine production by lymphocytes from patients with multiple sclerosis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 164
dc.relation.ispartofPAGINATION 104280
dc.relation.ispartofCOUNTRY Irlanda
dc.relation.ispartofCITY Limerick
dc.relation.ispartofTITLE Journal of reproductive immunology
dc.relation.ispartofISSN 1872-7603
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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