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Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis

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dc.contributor.author Marrodán, Mariano
dc.contributor.author Calandri, Ismael Luis
dc.contributor.author Bocancea, Diana I.
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Gómez Figueroa, Enrique
dc.contributor.author Massó Páez, Montserrat
dc.contributor.author Flores, José D.J.
dc.contributor.author Rojas, Juan I.
dc.contributor.author Ciampi, Ethel
dc.contributor.author Ioli, Pablo
dc.contributor.author Zanga, Gisela
dc.contributor.author Ardohain, Carolina
dc.contributor.author Fracaro, Maria E.
dc.contributor.author Amaya, Mariela
dc.contributor.author Tkachuk, Verónica
dc.contributor.author Fernández, Victoria C.
dc.contributor.author José, Gustavo
dc.contributor.author Silva, Emanuel
dc.contributor.author Luetic, Geraldine
dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author Köhler, Eduardo
dc.contributor.author Pagani Cassara, Fátima
dc.contributor.author Morán, Dolores
dc.contributor.author Seimandi, Carla
dc.contributor.author Paviolo, Juan P.
dc.contributor.author D'elio, Brenda
dc.contributor.author Da Prat, Gustavo
dc.contributor.author Gatto, Emilia
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Pujol Lereis, Virginia Andrea
dc.contributor.author Ameriso, Sebastián Francisco
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Correale, Jorge
dc.date.accessioned 2024-08-06T13:37:32Z
dc.date.available 2024-08-06T13:37:32Z
dc.date.issued 2024-07-26
dc.identifier.citation Marrodan M, Calandri IL, Bocancea DI, Ysrraelit MC, Gomez Figueroa E, Massó Páez M, Flores JDJ, Rojas JI, Ciampi E, Ioli P, Zanga G, Ardohain C, Fracaro ME, Amaya M, Tkachuk V, Fernandez VC, José G, Silva E, Luetic G, Carnero Contentti E, Köhler E, Pagani Cassara F, Moran D, Seimandi C, Paviolo JP, D'elio B, Da Prat G, Gatto E, Cristiano E, Pujol Lereis V, Ameriso SF, Fiol MP, Correale J. Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis. Ann Neurol. 2024 Jul 26. doi: 10.1002/ana.27043. Epub ahead of print. es_ES
dc.identifier.uri https://doi.org/10.1002/ana.27043
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1186
dc.description.abstract Objective: Susac syndrome (SuS), multiple sclerosis (MS), and primary angiitis of the central nervous system (PACNS) present diagnostic challenges due to overlapping clinical features. We aimed to enhance diagnostic precision by developing the SPAMS (SuS, PACNS, MS) score, a practical radiological tool. Methods: This multicenter study included 99 patients (43 SuS, 37 MS, 19 PACNS) from South American countries. Relevant MRI features were identified through an elastic-net model determined key variables. Results: The SPAMS score assigned 2 points for snowball lesions, 1 point for spokes-like lesions, or if there are more than 4 lesions in the corpus callosum, corpus callosum involvement, or cerebellar involvement. It subtracted 1 point if gadolinium-enhancing lesions or 4 points if Dawson's fingers are present. Bootstrapping validated the optimal cutoff at 2 points, exhibiting a diagnostic performance of area under the curve = 0.931, sensitivity = 88%, specificity = 89%, positive predictive value = 88%, negative predictive value = 89%, and accuracy = 88%. Interpretation: When specific MRI findings coexisted, the SPAMS score differentiated SuS from MS and PACNS. Access to MRI and standard protocol sequences makes it a valuable tool for timely diagnosis and treatment, potentially preventing disability progression and severe clinical outcomes. ANN NEUROL 2024. es_ES
dc.language.iso eng es_ES
dc.publisher Wiley-Liss es_ES
dc.subject Síndrome de Susac es_ES
dc.subject Susac Syndrome es_ES
dc.subject Vasculitis del Sistema Nervioso Central es_ES
dc.subject Vasculitis, Central Nervous System es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.title Diagnostic MRI Score to Differentiate Susac Syndrome from Primary Angiitis of the Central Nervous System and Multiple Sclerosis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Pujol Lereis, Virginia Andrea. Fleni. Centro Integral de Neurología Vascular; Argentina.
dc.description.fil Fil: Ameriso, Sebastián Francisco. Fleni. Centro Integral de Neurología Vascular; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología; Argentina.
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Annals of neurology
dc.relation.ispartofISSN 1531-8249
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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