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Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis

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dc.contributor.author Mosquera Heredia, Maria I.
dc.contributor.author Vidal, Oscar M.
dc.contributor.author Morales, Luis C.
dc.contributor.author Silvera Redondo, Carlos
dc.contributor.author Barceló, Ernesto
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Arcos Burgos, Mauricio
dc.contributor.author Vélez, Jorge I.
dc.contributor.author Garavito Galofre, Pilar
dc.date.accessioned 2024-09-02T13:36:00Z
dc.date.available 2024-09-02T13:36:00Z
dc.date.issued 2024-07-11
dc.identifier.citation Mosquera-Heredia MI, Vidal OM, Morales LC, Silvera-Redondo C, Barceló E, Allegri R, Arcos-Burgos M, Vélez JI, Garavito-Galofre P. Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis. Int J Mol Sci. 2024 Jul 11;25(14):7641. doi: 10.3390/ijms25147641. es_ES
dc.identifier.uri https://doi.org/10.3390/ijms25147641
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1201
dc.description.abstract Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied populations and developing countries. Instead, diagnosis is based on a combination of medical history, physical examination, cognitive testing, and brain imaging. Exosomes are extracellular nanovesicles, primarily composed of RNA, that participate in physiological processes related to AD pathogenesis such as cell proliferation, immune response, and neuronal and cardiovascular function. However, the identification and understanding of the potential role of long non-coding RNAs (lncRNAs) in AD diagnosis remain largely unexplored. Here, we clinically, cognitively, and genetically characterized a sample of 15 individuals diagnosed with AD (cases) and 15 controls from Barranquilla, Colombia. Advanced bioinformatics, analytics and Machine Learning (ML) techniques were used to identify lncRNAs differentially expressed between cases and controls. The expression of 28,909 lncRNAs was quantified. Of these, 18 were found to be differentially expressed and harbored in pivotal genes related to AD. Two lncRNAs, ENST00000608936 and ENST00000433747, show promise as diagnostic markers for AD, with ML models achieving > 95% sensitivity, specificity, and accuracy in both the training and testing datasets. These findings suggest that the expression profiles of lncRNAs could significantly contribute to advancing personalized AD diagnosis in this community, offering promising avenues for early detection and follow-up. es_ES
dc.language.iso eng es_ES
dc.publisher MDPI es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Diagnosis es_ES
dc.subject Diagnóstico es_ES
dc.subject Molecular Biology
dc.subject Biología Molecular
dc.title Long Non-Coding RNAs and Alzheimer's Disease: Towards Personalized Diagnosis es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Mosquera Heredia, Maria I. Universidad del Norte; Colombia.
dc.description.fil Fil: Vidal, Oscar M. Universidad del Norte; Colombia.
dc.description.fil Fil: Morales, Luis C. Universidad del Norte; Colombia.
dc.description.fil Fil: Silvera Redondo, Carlos. Universidad del Norte; Colombia.
dc.description.fil Fil: Barceló, Ernesto. Universidad de La Costa; Colombia.
dc.description.fil Fil: Arcos Burgos, Mauricio. Universidad de Antioquia; Colombia.
dc.description.fil Fil: Vélez, Jorge I. Universidad del Norte; Colombia.
dc.description.fil Fil: Garavito Galofre, Pilar. Universidad del Norte; Colombia.
dc.relation.ispartofVOLUME 25
dc.relation.ispartofNUMBER 14
dc.relation.ispartofPAGINATION 7641
dc.relation.ispartofCOUNTRY Suiza
dc.relation.ispartofCITY Basilea
dc.relation.ispartofTITLE International journal of molecular sciences
dc.relation.ispartofISSN 1422-0067
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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