dc.contributor.author |
Piedrabuena, María Agustina |
|
dc.contributor.author |
Correale, Jorge |
|
dc.contributor.author |
Farez, Mauricio Franco |
|
dc.contributor.author |
Rodríguez Murúa, Sofía |
|
dc.contributor.author |
Martínez Canyazo, Carlos |
|
dc.contributor.author |
Fiol, Marcela Paula |
|
dc.contributor.author |
Marrodán, Mariano |
|
dc.contributor.author |
Ysrraelit, María Célica |
|
dc.date.accessioned |
2024-09-30T13:49:25Z |
|
dc.date.available |
2024-09-30T13:49:25Z |
|
dc.date.issued |
2024-09-09 |
|
dc.identifier.citation |
Piedrabuena MA, Correale J, Farez MF, Rodríguez Murúa S, Martínez Canyazo C, Fiol M, Marrodan M, Ysrraelit MC. Telomere length as a biomarker in multiple sclerosis. Mult Scler. 2024 Sep;30(10):1258-1267. doi: 10.1177/13524585241273054. Epub 2024 Sep 9. |
es_ES |
dc.identifier.uri |
https://doi.org/10.1177/13524585241273054 |
|
dc.identifier.uri |
https://repositorio.fleni.org.ar/xmlui/handle/123456789/1207 |
|
dc.description.abstract |
Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).
Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.
Methods: Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.
Results: Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, p = 0.0081) and in males (female, 0.60; male, 0.59; p = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (p = 0.05), smoking (p = 0.03), Expanded Disability Status Scale (EDSS; p = 0.004), 9HPT (p = 0.00007), high-efficacy therapies (p = 0.001), brain lesion volume (BLV) (p = 0.011), and number of T2 lesions (p = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm3 and white matter volume 1.78 cm3.
Conclusion: LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS. |
es_ES |
dc.language.iso |
eng |
es_ES |
dc.publisher |
SAGE Publications |
es_ES |
dc.subject |
Esclerosis Múltiple |
es_ES |
dc.subject |
Multiple Sclerosis |
es_ES |
dc.subject |
Biomarcadores |
es_ES |
dc.subject |
Biomarkers |
es_ES |
dc.subject |
Telómero |
es_ES |
dc.subject |
Telomere |
es_ES |
dc.subject |
Envejecimiento |
es_ES |
dc.subject |
Aging |
es_ES |
dc.subject |
Enfermedades Desmielinizantes |
|
dc.subject |
Demyelinating Diseases |
|
dc.title |
Telomere length as a biomarker in multiple sclerosis |
es_ES |
dc.type |
info:eu-repo/semantics/article |
es_ES |
dc.description.fil |
Fil: Piedrabuena, María Agustina. Fleni. Departamento de Neurología; Argentina. |
|
dc.description.fil |
Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. |
|
dc.description.fil |
Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. |
|
dc.description.fil |
Fil: Rodríguez Murúa, Sofía. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. |
|
dc.description.fil |
Fil: Martínez Canyazo, Carlos. Fleni. Departamento de Neurología; Argentina. |
|
dc.description.fil |
Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología; Argentina. |
|
dc.description.fil |
Fil: Marrodán, Mariano. Fleni. Departamento de Neurología; Argentina. |
|
dc.description.fil |
Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. |
|
dc.relation.ispartofVOLUME |
30 |
|
dc.relation.ispartofNUMBER |
10 |
|
dc.relation.ispartofPAGINATION |
1258-1267. |
|
dc.relation.ispartofCOUNTRY |
Inglaterra |
|
dc.relation.ispartofCITY |
Londres |
|
dc.relation.ispartofTITLE |
Multiple sclerosis : clinical and laboratory research. |
|
dc.relation.ispartofISSN |
1477-0970 |
|
dc.type.snrd |
info:ar-repo/semantics/artículo |
es_ES |