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dc.contributor.author | Piedrabuena, María Agustina | |
dc.contributor.author | Correale, Jorge | |
dc.contributor.author | Farez, Mauricio Franco | |
dc.contributor.author | Rodríguez Murúa, Sofía | |
dc.contributor.author | Martínez Canyazo, Carlos | |
dc.contributor.author | Fiol, Marcela Paula | |
dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Ysrraelit, María Célica | |
dc.date.accessioned | 2024-09-30T13:49:25Z | |
dc.date.available | 2024-09-30T13:49:25Z | |
dc.date.issued | 2024-09-09 | |
dc.identifier.citation | Piedrabuena MA, Correale J, Farez MF, Rodríguez Murúa S, Martínez Canyazo C, Fiol M, Marrodan M, Ysrraelit MC. Telomere length as a biomarker in multiple sclerosis. Mult Scler. 2024 Sep;30(10):1258-1267. doi: 10.1177/13524585241273054. Epub 2024 Sep 9. | es_ES |
dc.identifier.uri | https://doi.org/10.1177/13524585241273054 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/xmlui/handle/123456789/1207 | |
dc.description.abstract | Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS). Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects. Methods: Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay. Results: Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, p = 0.0081) and in males (female, 0.60; male, 0.59; p = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (p = 0.05), smoking (p = 0.03), Expanded Disability Status Scale (EDSS; p = 0.004), 9HPT (p = 0.00007), high-efficacy therapies (p = 0.001), brain lesion volume (BLV) (p = 0.011), and number of T2 lesions (p = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm3 and white matter volume 1.78 cm3. Conclusion: LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | SAGE Publications | es_ES |
dc.subject | Esclerosis Múltiple | es_ES |
dc.subject | Multiple Sclerosis | es_ES |
dc.subject | Biomarcadores | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Telómero | es_ES |
dc.subject | Telomere | es_ES |
dc.subject | Envejecimiento | es_ES |
dc.subject | Aging | es_ES |
dc.subject | Enfermedades Desmielinizantes | |
dc.subject | Demyelinating Diseases | |
dc.title | Telomere length as a biomarker in multiple sclerosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.fil | Fil: Piedrabuena, María Agustina. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. | |
dc.description.fil | Fil: Rodríguez Murúa, Sofía. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina. | |
dc.description.fil | Fil: Martínez Canyazo, Carlos. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Marrodán, Mariano. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.relation.ispartofVOLUME | 30 | |
dc.relation.ispartofNUMBER | 10 | |
dc.relation.ispartofPAGINATION | 1258-1267. | |
dc.relation.ispartofCOUNTRY | Inglaterra | |
dc.relation.ispartofCITY | Londres | |
dc.relation.ispartofTITLE | Multiple sclerosis : clinical and laboratory research. | |
dc.relation.ispartofISSN | 1477-0970 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |