Survey among experts on the future role of tau-PET in clinical practice and trials

Vermeiren, Marie R.; Calandri, Ismael Luis; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik

dc.contributor.author	Vermeiren, Marie R.
dc.contributor.author	Calandri, Ismael Luis
dc.contributor.author	van der Flier, Wiesje M.
dc.contributor.author	van de Giessen, Elsmarieke
dc.contributor.author	Ossenkoppele, Rik
dc.date.accessioned	2024-12-10T15:45:06Z
dc.date.available	2024-12-10T15:45:06Z
dc.date.issued	2024
dc.identifier.citation	Vermeiren MR, Calandri IL, van der Flier WM, van de Giessen E, Ossenkoppele R. Survey among experts on the future role of tau-PET in clinical practice and trials. Alzheimers Dement (Amst). 2024 Nov 22;16(4):e70033. doi: 10.1002/dad2.70033.	es_ES
dc.identifier.uri	https://doi.org/10.1002/dad2.70033
dc.identifier.uri	https://repositorio.fleni.org.ar/xmlui/handle/123456789/1300
dc.description.abstract	Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the future. Methods: We conducted an online survey among dementia and PET experts worldwide to investigate the anticipated future role of tau-PET in clinical practice and trials. Results: Two hundred sixty-eight dementia experts, comprising 143 clinicians and 121 researchers, covering six continents participated. The vast majority (90%) fostered a positive attitude toward the added value of tau-PET in clinical practice, particularly for staging, diagnosing, monitoring, and prognostication in a cognitively impaired memory clinic population. Experts anticipated an important role for tau-PET for participant selection (76%-100%) and measuring endpoints (75%-97%), in both anti-amyloid and anti-tau drug trials. Discussion: Our global survey study shows that dementia experts envision an important role for tau-PET in the future, both in clinical practice and in drug trials, beyond current guidelines and practices. Highlights: Dementia experts envision an important role for tau-PET in the future.Experts indicate that a tau-PET scan could influence patient management.Experts anticipate the utility of tau-PET for participant selection and endpoints in drug trials.There is a gap between the anticipated usefulness of tau-PET and current clinical practices.	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Wiley on behalf of the Alzheimer's Association	es_ES
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Proteínas tau	es_ES
dc.subject	tau Proteins	es_ES
dc.subject	Tomografía de Emisión de Positrones	es_ES
dc.subject	Positron-Emission Tomography	es_ES
dc.subject	Alzheimer Disease	es_ES
dc.subject	Enfermedad de Alzheimer	es_ES
dc.title	Survey among experts on the future role of tau-PET in clinical practice and trials	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.fil	Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.relation.ispartofVOLUME	16
dc.relation.ispartofNUMBER	4
dc.relation.ispartofPAGINATION	e70033
dc.relation.ispartofCOUNTRY	Estados Unidos
dc.relation.ispartofCITY	Hoboken, NJ
dc.relation.ispartofTITLE	Alzheimer's & dementia : diagnosis, assessment & disease monitoring.
dc.relation.ispartofISSN	2352-8729
dc.type.snrd	info:ar-repo/semantics/artículo	es_ES