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Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies

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dc.contributor.author Marrodán, Mariano
dc.contributor.author Sao Avilés, Augusto
dc.contributor.author Río, Jordi
dc.contributor.author Cobo-Calvo, Álvaro
dc.contributor.author Fernández, Victoria
dc.contributor.author Pappolla, Agustin
dc.contributor.author Castilló, Joaquín
dc.contributor.author Vidal-Jordana, Ángela
dc.contributor.author Arrambide, Georgina
dc.contributor.author Tur, Carmen
dc.contributor.author Rodríguez-Acevedo, Breogán
dc.contributor.author Zabalza, Ana
dc.contributor.author Mongay-Ochoa, Neus
dc.contributor.author Vilaseca, Andreu
dc.contributor.author Rodriguez, Marta
dc.contributor.author Galán, Ingrid
dc.contributor.author Comabella, Manuel
dc.contributor.author Sastre-Garriga, Jaume
dc.contributor.author Tintoré, Mar
dc.contributor.author Auger, Cristina
dc.date.accessioned 2025-03-13T15:50:37Z
dc.date.available 2025-03-13T15:50:37Z
dc.date.issued 2025-02-10
dc.identifier.citation Marrodan M, Sao Avilés A, Río J, Cobo-Calvo Á, Fernández V, Pappolla A, et al. Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies. Mult Scler. 10 de febrero de 2025;13524585251316471. es_ES
dc.identifier.uri https://doi.org/10.1177/13524585251316471
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/1316
dc.description.abstract Background: Predicting treatment response and disease progression in multiple sclerosis (MS) is challenging. Treatment Response Scoring Systems (TRSS) are potentially useful, but their utility in patients receiving high-efficacy therapies and very high-efficacy therapies (HET/vHET) remains unclear. Objective: This study aimed to evaluate the performance of TRSS in patients treated with HET/vHET. Methods: We retrospectively studied MS patients treated with HET/vHET in an MS specialized centre. TRSS, including the Rio Score, modified Rio Score and MAGNIMS score, were applied to assess response to treatment. We evaluated the predictive value of the TRSS on disease activity and disability progression. Results: TRSS effectively predicted disease activity and progression of disability in patients treated with HET/vHET. Patients with high TRSS scores at 12 months post-HET/vHET initiation had a significantly increased risk of relapses, new lesions on magnetic resonance imaging (MRI) scans and progression of disability at 4 years. Discussion: Our findings highlight the importance of personalized treatment strategies in MS. TRSS are valuable tools for monitoring treatment response, guiding clinical decision-making and optimizing patient care. es_ES
dc.language.iso eng es_ES
dc.publisher Sage es_ES
dc.subject Multiple Sclerosis es_ES
dc.subject Esclerosis Múltiple es_ES
dc.subject Therapeutics es_ES
dc.subject Terapéutica es_ES
dc.title Performance of treatment response scoring systems among patients with multiple sclerosis treated with high-efficacy therapies es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Londres
dc.relation.ispartofTITLE Multiple sclerosis
dc.relation.ispartofISSN 1477-0970
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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