Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient

Vautier, Mercedes Florencia; Chrem Méndez, Patricio Alexis; Jerez Ferreyra, Guillermo; Massazza, Victoria; Apecetche, Manuela; Rodríguez Varela, María Soledad; Clas, Giulia Solange; Nievas, Micaela; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia; Romorini, Leonardo

Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient

Vautier, Mercedes Florencia; Chrem Méndez, Patricio Alexis; Jerez Ferreyra, Guillermo; Massazza, Victoria; Apecetche, Manuela; Rodríguez Varela, María Soledad; Clas, Giulia Solange; Nievas, Micaela; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Scassa, María Élida; Surace, Ezequiel Ignacio; Marazita, Mariela Claudia; Romorini, Leonardo

URI: https://doi.org/10.1016/j.scr.2026.103958
https://repositorio.fleni.org.ar/xmlui/handle/123456789/1618

Date: 2026-06

Abstract:

Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean Caucasian male patient with Autosomal-Dominant Alzheimer's Disease, who carried the heterozygous PSEN1 p.M146L mutation. The hiPSC line retained the PSEN1 mutation, and its pluripotency and trilineage differentiation potential were confirmed.

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