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Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients

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dc.contributor.author Abulafia, Carolina
dc.contributor.author Fiorentini, Leticia
dc.contributor.author Loewenstein, David A.
dc.contributor.author Curiel-Cid, Rosie
dc.contributor.author Sevlever, Gustavo Emilio
dc.contributor.author Nemeroff, Charles B.
dc.contributor.author Villarreal, Mirta Fabiana
dc.contributor.author Vigo, Daniel Eduardo
dc.contributor.author Guinjoan, Salvador Martín
dc.date.accessioned 2020-02-03T13:39:30Z
dc.date.available 2020-02-03T13:39:30Z
dc.date.issued 2019-02-22
dc.identifier.citation Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Psy.D, Sevlever, G., Nemeroff, C.B., Villarreal, M.F., Vigo, D.E., Guinjoan, S.M., 2019. Executive Functioning in Cognitively Normal Middle-Aged Offspring of Late-Onset Alzheimer’s Disease Patients. J . Psychiatric Res. 2019 May;112:23-29. doi: 10.1016/j.jpsychires.2019.02.016. Epub 2019 Feb 22. en_US
dc.identifier.uri https://doi.org/10.1016/j.jpsychires.2019.02.016
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/168
dc.description.abstract Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions subserving executive functions in asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD), suggesting that premature episodic memory deficits could be associated to executive dysfunction in this model. We hypothesized that O-LOAD would exhibit reduced executive performance evidenced by increased errors and decreased strategy use on an episodic memory task. We assessed 32 asymptomatic middle-aged O-LOAD and 28 age-equivalent control subjects (CS) with several tests that measure executive functions and the Rey Auditory Verbal Learning Test (RAVLT) to measure memory performance. All tests were scored using both traditional and process scores (quantification of errors and strategies underlying overall performance). T-tests were used to compare performance between both groups and Spearman correlations were implemented to measure associations between variables. O-LOAD participants exhibited decreased executive performance compared to CS as it relates to initiation time (Tower of London), mental switching (Trail Making Test B), and interference effects (Stroop Word-Color condition). Traditional RAVLT measures showed a poorer performance by O-LOAD and RAVLT process scores revealed increased interference effects on this group. Positive correlations (rs) were found between the executive measures and several RAVLT measures for O-LOAD but not for CS. In conclusion, O-LOAD participants exhibited early subtle cognitive changes in executive processing. Observed memory difficulties may be associated in part to executive deficits suggesting an interplay between memory and executive functions. Process score impairments were observed earlier than clinical decline on neuropsychological scores in this at-risk cohort and might be useful cognitive markers of preclinical LOAD. en_US
dc.language.iso eng en_US
dc.publisher Oxford en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Executive Function en_US
dc.subject Función Ejecutiva en_US
dc.subject Alzheimer Disease en_US
dc.subject Enfermedad de Alzheimer en_US
dc.subject Rey Auditory Verbal Learning Test en_US
dc.subject RAVLT en_US
dc.title Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Abulafia, Carolina. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina.
dc.description.fil Fil: Fiorentini, Leticia. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Loewenstein, David A. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos.
dc.description.fil Fil: Curiel-Cid, Rosie. University of Miami. Miller School of Medicine. Department of Psychiatry and Behavioral Sciences and Center on Aging; Estados Unidos.
dc.description.fil Fil: Sevlever, Gustavo Emilio. Fleni. Departamento de Neuropatología y Biología Molecular; Argentina. Fleni. Departamento de Docencia e Investigación; Argentina.
dc.description.fil Fil: Nemeroff, Charles B. The University of Texas. Dell Medical School. Institute of Early Life Adversity Research; Estados Unidos.
dc.description.fil Fil: Villarreal, Mirta Fabiana. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica Argentina. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Katholieke Universiteit Leuven. School of Psychology and Educational Sciences; Bélgica.
dc.description.fil Fil: Guinjoan, Salvador Martín. Fleni. Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fleni. Servicio de Psiquiatría; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Psiquiatría y Salud Mental; Argentina.
dc.relation.ispartofVOLUME 112
dc.relation.ispartofPAGINATION 23-29
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Oxford
dc.relation.ispartofTITLE Journal of psychiatric research
dc.relation.ispartofISSN 1879-1379
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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