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Transferrin Enhances Microglial Phagocytic Capacity

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dc.contributor.author Carden, Tomás Roberto
dc.contributor.author Correale, Jorge
dc.contributor.author Pasquini, Juana María
dc.contributor.author Pérez, María Julia
dc.date.accessioned 2020-02-06T13:53:22Z
dc.date.available 2020-02-06T13:53:22Z
dc.date.issued 2019-02-13
dc.identifier.citation Carden, T.R., Correale, J., Pasquini, J.M., Pérez, M.J. Transferrin Enhances Microglial Phagocytic Capacity. Mol Neurobiol. 2019 Sep;56(9):6324-6340. doi: 10.1007/s12035-019-1519-0. Epub 2019 Feb 13. en_US
dc.identifier.uri https://doi.org/10.1007/s12035-019-1519-0
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/178
dc.description.abstract Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells. This molecule has been shown to accelerate the process of myelination and remyelination in the central nervous system (CNS) in vivo and induce oligodendroglial cell maturation in vitro. While the mechanisms involved in oligodendroglial precursor cell (OPC) differentiation have not been fully elucidated yet, our group has previously described the first molecular events taking place in OPC in response to extracellular Tf. Here, we show the effect of Tf on the different glial cell populations. We demonstrate that, after a CNS demyelinating injury, Tf can be incorporated by all glial cells-i.e., microglia, astrocytes, and OPC-and that, acting on microglial cells in vitro, Tf increases microglial proliferation rates and phagocytic capacity. It may be then speculated that the in vivo correlation of this process could generate a favorable microenvironment for OPC maturation and remyelination. en_US
dc.language.iso eng en_US
dc.publisher Humana Press en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Astrocytes en_US
dc.subject Astrocitos en_US
dc.subject Demyelinating Diseases en_US
dc.subject Enfermedades Desmielinizantes en_US
dc.subject Phagocytosis en_US
dc.subject Fagocitosis en_US
dc.subject Remyelination en_US
dc.subject Remielinización en_US
dc.subject Transferrin en_US
dc.subject Transferrina en_US
dc.title Transferrin Enhances Microglial Phagocytic Capacity en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Carden, Tomás R. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológica "Prof. Alejandro C. Paladini"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Pasquini, Juana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológica "Prof. Alejandro C. Paladini"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.description.fil Fil: Pérez, María Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológica "Prof. Alejandro C. Paladini"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
dc.relation.ispartofVOLUME 56
dc.relation.ispartofNUMBER 9
dc.relation.ispartofPAGINATION 6324-6340
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Clifton
dc.relation.ispartofTITLE Molecular neurobiology
dc.relation.ispartofISSN 1559-1182
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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