DSpace Repository

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

Show simple item record

dc.contributor.author Aschenbrenner, Andrew J.
dc.contributor.author James, Bryan D.
dc.contributor.author McDade, Eric
dc.contributor.author Wang, Guoqiao
dc.contributor.author Lim, Yen Ying
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Cruchaga, Carlos
dc.contributor.author Goate, Alison M.
dc.contributor.author Xiong, Chengjie
dc.contributor.author Perrin, Richard J.
dc.contributor.author Buckles, Virginia
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Berman, Sarah B.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Fagan, Anne M.
dc.contributor.author Farlow, Martin R.
dc.contributor.author O’Connor, Antoinette
dc.contributor.author Ghetti, Bernardino
dc.contributor.author Graff-Radford, Neill R.
dc.contributor.author Goldman, Jill
dc.contributor.author Gräber, Susanne
dc.contributor.author Karch, Celeste M.
dc.contributor.author Lee, Jae-Hong
dc.contributor.author Levin, Johannes
dc.contributor.author Martins, Ralph N.
dc.contributor.author Masters, Colin L.
dc.contributor.author Mori, Hiroshi
dc.contributor.author Noble, James M.
dc.contributor.author Salloway, Stephen
dc.contributor.author Schofield, Peter R.
dc.contributor.author Morris, John C.
dc.contributor.author Bateman, Randall J.
dc.contributor.author Hassenstab, Jason
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2020-11-05T16:22:01Z
dc.date.available 2020-11-05T16:22:01Z
dc.date.issued 2020-06
dc.identifier.citation Aschenbrenner, A.J., James, B.D., McDade, E., Wang, G., Lim, Y.Y., Benzinger, T.L.S., Cruchaga, C., Goate, A., Xiong, C., Perrin, R., Buckles, V., Allegri, R., Berman, S.B., Chhatwal, J.P., Fagan, A.M., Farlow, M., O’Connor, A., Ghetti, B., Graff-Radford, N., Goldman, J., Gräber, S., Karch, C.M., Lee, J.-H., Levin, J., Martins, R.N., Masters, C., Mori, H., Noble, J., Salloway, S., Schofield, P., Morris, J.C., Bateman, R.J., Hassenstab, J., 2020. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimers Dement 16, 219–228. https://doi.org/10.1002/alz.12010 en_US
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/223
dc.identifier.uri https://doi.org/10.1002/alz.12010
dc.description.abstract Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is unknown. This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers. Methods: Mutation carriers and non-carriers from the Dominantly Inherited Alzheimer Network (DIAN) were stratified based on knowledge of mutation status. Rates of change on standard clinical, cognitive, and neuroimaging outcomes were examined. Results: Mutation knowledge had no associations with cognitive decline, clinical progression, amyloid deposition, hippocampal volume, or depression in either carriers or non-carriers. Carriers who learned their status mid-study had slightly higher levels of depression and lower cognitive scores. Discussion: Knowledge of mutation status does not affect rates of change on any measured outcome. Learning of status mid-study may confer short-term changes in cognitive functioning, or changes in cognition may influence the determination of mutation status. en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease en_US
dc.subject Enfermedad de Alzheimer en_US
dc.subject Risk Factors en_US
dc.subject Factores de Riesgo en_US
dc.title Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Aschenbrenner, Andrew J. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: James, Bryan D. Rush Alzheimer's Disease Center. Rush University Medical Center. Department of Internal Medicine; Estados Unidos.
dc.description.fil Fil: McDade, Eric. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: Wang, Guoquiao. Washington University School of Medicine. Division of Biostatistics; Estados Unidos.
dc.description.fil Fil: Lim, Yen Ying. The Florey Institute of Neuroscience and Mental Health, Parkville; Australia.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Radiology; Estados Unidos.
dc.description.fil Fil: Cruchaga, Carlos. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University School of Medicine. Department of Psychiatry; Estados Unidos.
dc.description.fil Fil: Goate, Alison M. Icahn School of Medicine at Mount Sinai. Department of Neuroscience; Estados Unidos.
dc.description.fil Fil: Xiong, Chengjie. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos. Washington University School of Medicine. Division of Biostatistics; Estados Unidos.
dc.description.fil Fil: Perrin, Richard J. Washington University School of Medicine. Department of Pathology & Immunology. Division of Neuropathology; Estados Unidos.
dc.description.fil Fil: Buckles, Virginia. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: Berman, Sarah B. University of Pittsburgh. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Massachusetts General Hospital, Harvard Medical School. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Fagan, Anne M. Washington University School of Medicine. Department of Neurology. Charles F. and Joanne Knight Alzheimer's Disease Research Center; Estados Unidos.
dc.description.fil Fil: Farlow, Martin R. Indiana University School of Medicine. Department of Neurology; Estados Unidos.
dc.description.fil Fil: O’Connor, Antoinette. Queen Square Institute of Neurology. Dementia Research Centre; Inglaterra.
dc.description.fil Fil: Ghetti, Bernardino. Indiana University School of Medicine. Department of Pathology and Laboratory Medicine; Estados Unidos.
dc.description.fil Fil: Graff-Radford, Neill R. Mayo Clinic. Department of Neurology; Estados Unidos.
dc.description.fil Fil: Goldman, Jill. Columbia University. Department of Neurology; Estados Unidos.
dc.relation.ispartofVOLUME 16
dc.relation.ispartofNUMBER 1
dc.relation.ispartofPAGINATION 219-228
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofTITLE Alzheimer's & dementia : the journal of the Alzheimer's Association
dc.relation.ispartofISSN 1552-5279
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess

Search DSpace


Browse

My Account

Statistics