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Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis

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dc.contributor.author Zuluaga, María I.
dc.contributor.author Otero-Romero, Susana
dc.contributor.author Rovira, Álex
dc.contributor.author Perez Hoyos, Santiago
dc.contributor.author Arrambide, Georgina
dc.contributor.author Negrotto, Laura
dc.contributor.author Galán, Ingrid
dc.contributor.author Río, Jordi
dc.contributor.author Comabella, Manuel
dc.contributor.author Nos, Carlos
dc.contributor.author Arévalo, María Jesus
dc.contributor.author Vidal Jordana, Angela
dc.contributor.author Castilló, Joaquín
dc.contributor.author Rodríguez, Breogán
dc.contributor.author Midaglia, Luciana
dc.contributor.author Mulero, Patricia
dc.contributor.author Mitjana, Raquel
dc.contributor.author Auger, Cristina
dc.contributor.author Sastre Garriga, Jaume
dc.contributor.author Montalban, Xavier
dc.contributor.author Tintoré, Mar
dc.date.accessioned 2020-11-09T13:41:02Z
dc.date.available 2020-11-09T13:41:02Z
dc.date.issued 2019-03-01
dc.identifier.citation Zuluaga, M.I., Otero-Romero, S., Rovira, A., Perez-Hoyos, S., Arrambide, G., Negrotto, L., Galán, I., Río, J., Comabella, M., Nos, C., Arévalo, M.J., Vidal-Jordana, A., Castilló, J., Rodríguez, B., Midaglia, L., Mulero, P., Mitjana, R., Auger, C., Sastre-Garriga, J., Montalban, X., Tintoré, M. Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis. Neurology 2019 Mar 26;92(13):e1507-e1516. doi: 10.1212/WNL.0000000000007178. Epub 2019 Mar 1. en_US
dc.identifier.uri https://doi.org/10.1212/WNL.0000000000007178
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/225
dc.description.abstract Objective: To investigate the effect of menarche, pregnancies, and breastfeeding on the risk of developing multiple sclerosis (MS) and disability accrual using a multivariate approach based on a large prospective cohort of patients with clinically isolated syndrome (CIS). Methods: A cross-sectional survey of the reproductive information of female participants in a CIS cohort was performed. We examined the relationship of age at menarche with the risk of clinically definite MS (CDMS), McDonald 2010 MS, and Expanded Disability Status Scale (EDSS) 3.0 and 6.0. The effect of pregnancy (before and after CIS) and breastfeeding in the risk of CDMS, McDonald 2010 MS, and EDSS 3.0 was also examined. Univariate and multivariate analyses were performed and findings were confirmed using sensitivity analyses and a propensity score model. Results: The data of 501 female participants were collected. Age at menarche did not correlate with age at CIS and was not associated with the risk of CDMS or EDSS 3.0 or 6.0. Pregnancy before CIS was protective for CDMS in the univariate analysis, but the effect was lost in the multivariate model and did not modify the risk of EDSS 3.0. Pregnancy after CIS was protective for both outcomes in univariate and multivariate analyses when pregnancy was considered a baseline variable, but the protective effect disappeared when analyzed as a time-dependent event. Breastfeeding did not modify the risk for the 3 outcomes. Conclusions: These results demonstrate that menarche, pregnancies, and breastfeeding did not substantially modify the risk of CDMS or disability accrual using a multivariable and time-dependent approach. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Breast Feeding en_US
dc.subject Lactancia Materna en_US
dc.subject Demyelinating Diseases en_US
dc.subject Enfermedades Desmielinizantes en_US
dc.subject Pregnancy en_US
dc.subject Embarazo en_US
dc.subject Reproductive History en_US
dc.subject Historia Reproductiva en_US
dc.title Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Zuluaga, María I. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Otero Romero, Susana. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Rovira, Álex. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Perez Hoyos, Santiago. Hospital Universitari Vall d’Hebron; España.
dc.description.fil Fil: Arrambide, Georgina. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Negrotto, Laura. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Galán, Ingrid. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Río, Jordi. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Comabella, Manuel. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Nos, Carlos. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Arévalo, María Jesus. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Vidal Jordana, Angela. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Castilló, Joaquín. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Rodríguez, Breogán. Centre d’Esclerosi Múltiple de Catalunya, España.
dc.description.fil Fil: Midaglia, Luciana. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Mulero, Patricia. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Mitjana, Raquel. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Auger, Cristina. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Sastre Garriga, Jaume. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.description.fil Fil: Montalban, Xavier. Hospital Universitari Vall d’Hebron; España. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Tintoré, Mar. Centre d’Esclerosi Múltiple de Catalunya; España.
dc.relation.ispartofVOLUME 92
dc.relation.ispartofNUMBER 13
dc.relation.ispartofPAGINATION e1507-e1516
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Hagerstown
dc.relation.ispartofTITLE Neurology
dc.relation.ispartofISSN 1526-632X
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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