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Auflistung Neurología Cognitiva.artículos Nach Schlagwort "Alzheimer Disease"

Auflistung Neurología Cognitiva.artículos Nach Schlagwort "Alzheimer Disease"

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  • Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease 
    Horie, Kanta; Li, Yan; Barthélemy, Nicolas R.; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Day, Gregory S.; Schofield, Peter R.; Dominantly Inherited Alzheimer Network (Wiley, 2023-03-16)
    Objective: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary ...
  • Clinical Manifestations 
    Clarens, María Florencia; Chrem Méndez, Patricio Alexis; Tapajóz Pereira de Sampaio, Fernanda; Martinez, Carlos; Helou, María Belén; Surace, Ezequiel Ignacio; Crivelli, Lucía; Romero, Daniela; Vigo, Gabriela; Allegri, Ricardo Francisco (Wiley, 2023-12-25)
    Background: In recent years, there has been an increase in the number of case reports of families with autosomal dominant Alzheimer's disease (ADAD) in Latin America (LA). Nevertheless, little is known about the clinical ...
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease 
    Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter U.; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease 
    Hofmann, Anna; Häsler, Lisa M.; Lambert, Marius; Kaeser, Stephan A.; Gräber-Sultan, Susanne; Obermüller, Ulrike; Kuder-Buletta, Elke; La Fougère, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Fox, Nick C.; Ryan, Natalie S.; Zetterberg, Henrik; Llibre Guerra, Jorge J.; Perrin, Richard J.; Ibanez, Laura; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Dominantly Inherited Alzheimer Network (Nature Pub. Group, 2024)
    Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, ...
  • Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease 
    Allegri, Ricardo Francisco; Dincer, Aylin; Gordon, Brian A.; Hari-Raj, Amrita; Keefe, Sarah J.; Flores, Shaney; McKay, Nicole S.; Paulick, Angela M.; Shady Lewis, Kristine E.; Feldman, Rebecca L.; Hornbeck, Russ C.; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Farlow, Martin R.; La Fougère, Christian; Fox, Nick C.; Fulham, Michael J.; Jack Jr, Clifford R.; Joseph-Mathurin, Nelly; Karch, Celeste M.; Lee, Athene; Levin, Johannes; Masters, Colin L.; McDade, Eric; Oh, Hwamee; Perrin, Richard J.; Raji, Cyrus; Salloway, Stephen; Schofield, Peter R.; Su, Yi; Villemagne, Victor L.; Wang, Qing; Weiner, Michael W.; Xiong, Chengjie; Yakushev, Igor; Morris, John C.; Bateman, Randall J.; Benzinger, Tammie L.S.; Dominantly Inherited Alzheimer Network (Elsevier, 2020-11-05)
    Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since ...
  • Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study 
    Boerwinkle, Anna H.; Gordon, Brian A.; Wisch, Julie K.; Flores, Shaney; Henson, Rachel L.; Butt, Omar H.; McKay, Nicole S.; Chen, Charles D.; Benzinger, Tammie L.S.; Fagan, Anne M.; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Egido, Noelia (Elsevier, 2022-12-12)
    Background: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial ...
  • Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study 
    Fagan, Anne M.; Henson, Rachel L.; Li, Yan; Boerwinkle, Anna H.; Xiong, Chengjie; Bateman, Randall J.; Goate, Alison M.; Ances, Beau M.; Doran, Eric; Christian, Bradley T.; Lai, Florence; Rosas, H. Diana; Schupf, Nicole; Krinsky-McHale, Sharon J.; Silverman, Wayne; Lee, Joseph H.; Klunk, William E.; Handen, Benjamin L.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network (Elsevier, 2021-08)
    Background Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at ...
  • Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study 
    Wisch, Julie K.; McKay, Nicole S.; Boerwinkle, Anna H.; Kennedy, James; Flores, Shaney; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; O'Bryant, Sid E.; Price, Julie C.; Laymon, Charles M.; Krinsky-McHale, Sharon J.; Lai, Florence; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio (Lancet Pub. Group, 2024-05)
    Background: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and ...
  • Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing 
    Falasco, Germán; Damián, Andrés; Urrutia, Leandro; Niell, Nicolás; Lago, Graciela; Bérgamo, Yanina; Chrem Méndez, Patricio Alexis; Quagliata, Adriana; Bentancourt, Cecilia; Calandri, Ismael Luis; Cordero, Ismael; Ponce de León, Magdalena; Contreras, Valeria; Feuerstein, Viviana; Dansilio, Sergio; Allegri, Ricardo Francisco; Engler, Henry; Vázquez, Silvia (Bentham Science Publishers, 2021-11-15)
    Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease 
    Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John P.; Do, Anh; Liu, Haiyan; Gordon, Brian A.; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)
    In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
  • Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance 
    Howard, Leanne; Abdelnour, Carla; Abner, Erin L.; Allegri, Ricardo Francisco; Dodge, Hiroko H.; Gauthier, Serge; Hoyos, Camilla M.; Jicha, Gregory A.; Kehoe, Patrick G.; Mummery, Catherine J.; Ogunniyi, Adesola; Scarmeas, Nikolaos; Chen, Xiaoying; Titiner, Jodie R.; Weber, Christopher R.; Clinical Trial Methodology Working review group members; Peters, Ruth (John Wiley & Sons, 2024-06-02)
    Introduction: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated ...
  • Deficits of Alzheimer's Disease Neuropsychological Architecture Correlate with Specific Exosomal mRNA Expression: Evidence of a Continuum? 
    Barceló Martínez, Ernesto; Mosquera-Heredia, María I.; Vidal, Oscar M.; Bolívar, Daniel A.; Allegri, Ricardo Francisco; Morales, Luis C.; Silvera-Redondo, Carlos; Arcos-Burgos, Mauricio; Garavito-Galofre, Pilar; Vélez, Jorge I. (MDPI, 2025-05-20)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and complex molecular changes. Extracellular vesicles (EVs), particularly exosomes, play a key role in intercellular communication ...
  • Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project) 
    Udeh-Momoh, Chinedu T.; Maina, Rachel; Anazodo, Udunna C.; Akinyemi, Rufus; Atwoli, Lukoye; Baker, Laura; Bassil, Darina; Blackmon, Karen; Bosire, Edna; Chemutai, Gloria; Crivelli, Lucía; Ez, Laz U.; Ibanez, Agustin; Kafetsouli, Dimitra; Karikari, Thomas K.; Khakali, Linda; Kumar, Manasi; Lengyel, Imre; de Jager Loots, Celeste A.; Africa‐FINGERS Study Team (John Wiley & Sons, 2024-11-07)
    Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to ...
  • Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease 
    Saposnik, Gustavo; Sánchez-Benavidez, Gonzalo; García-Arcelay, Elena; Franco-Macías, Emilio; Bensi, Catalina; Carmelingo, Sebastián; Allegri, Ricardo Francisco; Pérez-Martíne, David A.; Maurino, Jorge (Springer, 2023-03-23)
    Introduction: The current therapeutic landscape of Alzheimer's disease (AD) is evolving rapidly. Our treatment options include new anti-amyloid-β protein disease-modifying therapies (DMTs) that decrease cognitive decline ...
  • Detection of emerging neurodegeneration using Bayesian linear mixed-effect modeling 
    Cobigo, Yann; Goh, Matthew S.; Wolf, Amy; Staffaroni, Adam M.; Kornak, John; Miller, Bruce L.; Rabinovici, Gil D.; Seeley, William W.; Spina, Salvatore; Boxer, Adam L.; Boeve, Bradley F.; Wang, Lei; Allegri, Ricardo Francisco; Farlow, Marty; Mori, Hiroshi; Perrin, Richard J.; Kramer, Joel H.; Rosen, Howard J.; Alzheimer’s Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network (Elsevier, 2022-07-06)
    Early detection of neurodegeneration, and prediction of when neurodegenerative diseases will lead to symptoms, are critical for developing and initiating disease modifying treatments for these disorders. While each ...
  • Diabetic patients treated with metformin during early stages of Alzheimer's disease show a better integral performance: data from ADNI study 
    Pomilio, Carlos; González Pérez, Nicolás; Calandri, Ismael Luis; Crivelli, Lucía; Allegri, Ricardo Francisco; ADNI Alzheimer’s Disease Neuroimaging Initiative; Sevlever, Gustavo Emilio; Saravia, Flavia (Springer International Publishing, 2022-06)
    We evaluated the effect of the antidiabetic drug metformin on patients enrolled in the ADNI study considering patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Employing data from this observational ...
  • Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer's disease in Colombia 
    Porto, Maria F.; Benitez Agudelo, Juan Camilo; Aguirre Acevedo, Daniel Camilo; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco (Taylor & Francis, 2021-03-24)
    Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. ...
  • DIAN-TU ARGENTINA. A great human story of a small group of people 
    Chrem Méndez, Patricio Alexis; Bagnati, Pablo M. (Universidad de la Costa, 2021-08-27)
    Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the ...
  • Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease 
    Buckles, Virginia; Xiong, Chengjie; Bateman, Randall J.; Hassenstab, Jason; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Danek, Adrian; Fagan, Anne M.; Ghetti, Bernardino; Goate, Alison M.; Graff-Radford, Neill R.; Jucker, Mathias; Levin, Johannes; Marcus, Daniel S.; Masters, Colin L.; McCue, Lena M.; McDade, Eric; Mori, Hiroshi; Moulder, Krista L. (John Wiley & Sons, 2021-12-02)
    As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine ...

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