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ListarNeurología Cognitiva.artículos por tema "Alzheimer Disease"

ListarNeurología Cognitiva.artículos por tema "Alzheimer Disease"

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  • Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study 
    Fagan, Anne M.; Henson, Rachel L.; Li, Yan; Boerwinkle, Anna H.; Xiong, Chengjie; Bateman, Randall J.; Goate, Alison M.; Ances, Beau M.; Doran, Eric; Christian, Bradley T.; Lai, Florence; Rosas, H. Diana; Schupf, Nicole; Krinsky-McHale, Sharon; Silverman, Wayne; Lee, Joseph H.; Klunk, William E.; Handen, Benjamin L.; Allegri, Ricardo Francisco; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network (Elsevier, 2021-08)
    Background Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at ...
  • Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study 
    Wisch, Julie K.; McKay, Nicole S.; Boerwinkle, Anna H.; Kennedy, James; Flores, Shaney; Handen, Benjamin L.; Christian, Bradley T.; Head, Elizabeth; Mapstone, Mark; Rafii, Michael S.; O'Bryant, Sid E.; Price, Julie C.; Laymon, Charles M.; Krinsky-McHale, Sharon J.; Lai, Florence; Alzheimer's Biomarker Consortium-Down syndrome; Dominantly Inherited Alzheimer Network; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio (Lancet Pub. Group, 2024-05)
    Background: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and ...
  • Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing 
    Falasco, Germán; Damián, Andrés; Urrutia, Leandro; Niell, Nicolás; Lago, Graciela; Bérgamo, Yanina; Chrem Méndez, Patricio Alexis; Quagliata, Adriana; Bentancourt, Cecilia; Calandri, Ismael Luis; Cordero, Ismael; Ponce de León, Magdalena; Contreras, Valeria; Feuerstein, Viviana; Dansilio, Sergio; Allegri, Ricardo Francisco; Engler, Henry; Vazquez, Silvia (Bentham Science Publishers, 2021-11-15)
    Purpose: The aim of this study was to investigate the differences in early (EOAD) and late (LOAD) onset of Alzheimer´s disease, as well as glucose uptake, regional cerebral blood flow (R1), amyloid depositions, and functional ...
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease 
    Xiong, Chengjie; McCue, Lena M.; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J.; Fagan, Anne M.; Benzinger, Tammie L.S.; Hassenstab, Jason; Schindler, Suzanne E.; McDade, Eric; Moulder, Krista L.; Gordon, Brian A.; Cruchaga, Carlos; Day, Gregory S.; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Wiley, 2023-01-14)
    Background: Comparisons of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods: We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and ...
  • Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease 
    Saposnik, Gustavo; Sánchez-Benavidez, Gonzalo; García-Arcelay, Elena; Franco-Macías, Emilio; Bensi, Catalina; Carmelingo, Sebastián; Allegri, Ricardo Francisco; Pérez-Martíne, David A.; Maurino, Jorge (Springer, 2023-03-23)
    Introduction: The current therapeutic landscape of Alzheimer's disease (AD) is evolving rapidly. Our treatment options include new anti-amyloid-β protein disease-modifying therapies (DMTs) that decrease cognitive decline ...
  • Detection of emerging neurodegeneration using Bayesian linear mixed-effect modeling 
    Cobigo, Yann; Goh, Matthew S.; Wolf, Amy; Staffaroni, Adam M.; Kornak, John; Miller, Bruce L.; Rabinovici, Gil D.; Seeley, William W.; Spina, Salvatore; Boxer, Adam L.; Boeve, Bradley F.; Wang, Lei; Allegri, Ricardo Francisco; Farlow, Marty; Mori, Hiroshi; Perrin, Richard J.; Kramer, Joel; Rosen, Howard J.; Alzheimer’s Disease Neuroimaging Initiative; Dominantly Inherited Alzheimer Network (Elsevier, 2022-07-06)
    Early detection of neurodegeneration, and prediction of when neurodegenerative diseases will lead to symptoms, are critical for developing and initiating disease modifying treatments for these disorders. While each ...
  • Diabetic patients treated with metformin during early stages of Alzheimer's disease show a better integral performance: data from ADNI study 
    Pomilio, Carlos; González Pérez, Nicolás; Calandri, Ismael Luis; Crivelli, Lucía; Allegri, Ricardo Francisco; ADNI Alzheimer’s Disease Neuroimaging Initiative; Sevlever, Gustavo Emilio; Saravia, Flavia (Springer International Publishing, 2022-06)
    We evaluated the effect of the antidiabetic drug metformin on patients enrolled in the ADNI study considering patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Employing data from this observational ...
  • Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer's disease in Colombia 
    Porto, Maria F.; Benitez Agudelo, Juan Camilo; Aguirre Acevedo, Daniel Camilo; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco (Taylor & Francis, 2021-03-24)
    Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. ...
  • DIAN-TU ARGENTINA. A great human story of a small group of people 
    Chrem Méndez, Patricio Alexis; Bagnati, Pablo M. (Universidad de la Costa, 2021-08-27)
    Alzheimer’s disease is, by far the first, cause of dementia and the more frequent neurodegenerative disease. Considered as a result of multifactorial causes, aging is the main risk factor for the classical form of the ...
  • Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease 
    Buckles, Virginia; Xiong, Chengjie; Bateman, Randall J.; Hassenstab, Jason; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Danek, Adrian; Fagan, Anne M.; Ghetti, Bernardino; Goate, Alison M.; Graff-Radford, Neill R.; Jucker, Mathias; Levin, Johannes; Marcus, Daniel S.; Masters, Colin L.; McCue, Lena M.; McDade, Eric; Mori, Hiroshi; Moulder, Krista L. (John Wiley & Sons, 2021-12-02)
    As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • Dominantly inherited Alzheimer's disease in Latin America: Genetic heterogeneity and clinical phenotypes 
    Llibre Guerra, Jorge J.; Li, Yan; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Llibre Rodríguez, Juan J.; Sosa, Ana Luisa; Aláez-Verson, Carmen; Longoria, Erika-Mariana; Tellez, Alberto; Carrillo Sánchez, Karol; Flores Lagunes, Luis Leonardo; Sánchez, Victor; Tadao Takada, Leonel; Nitrini, Ricardo; Ferreira Frota, Norberto Anizio; Benevides Lima, Joyce; Lopera, Francisco; Ramírez, Laura; Jiménez Velázquez, Ivonne (John Wiley & Sons, 2021-04)
    Introduction: A growing number of dominantly inherited Alzheimer's disease (DIAD) cases have become known in Latin American (LatAm) in recent years. However, questions regarding mutation distribution and frequency by country ...
  • Driving and Alzheimer’s disease: A neuropsychological screening battery for the elderly 
    Crivelli, Lucía; Russo, María Julieta; Farez, Mauricio Franco; Bonetto, Mariana; Prado, Cecilia; Calandri, Ismael Luis; Campos, Jorge; Cohen, Gabriela; Chrem Méndez, Patricio Alexis; Sabe, Liliana Raquel; Allegri, Ricardo Francisco (Associação Neurologia Cognitiva e do Comportamento, 2019-07-01)
    As life expectancy increases, there is a marked increase in the elderly population eager to continue driving. A large proportion of these elderly drive safely, however, patients with mild dementia are high-risk drivers. ...
  • Escala de detección de olvidos. Una herramienta de rastrillaje para el deterioro cognitivo leve 
    Cerviño, Cecilia; Crivelli, Lucía; Calandri, Ismael Luis; Allegri, Ricardo Francisco (Universidad de Montreal, 2019-12-30)
    En los últimos años han incrementado las consultas por fallas de memoria, dado que ha aumentado la expectativa de vida. La prevalencia de trastornos mnésicos en la edad adulta, requiere instrumentos de rastrillaje sensibles, ...
  • Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients 
    Abulafia, Carolina; Fiorentini, Leticia; Loewenstein, David A.; Curiel-Cid, Rosie; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Villarreal, Mirta Fabiana; Vigo, Daniel Eduardo; Guinjoan, Salvador Martín (Oxford, 2019-02-22)
    Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions ...
  • First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study 
    O'Connor, Antoinette; Rice, Helen; Barnes, Josephine; Ryan, Natalie S.; Liu, Kathy Y.; Allegri, Ricardo Francisco; Berman, Sarah B.; Ringman, John M.; Cruchaga, Carlos; Farlow, Martin R.; Hassenstab, Jason; Lee, Jae-Hong; Perrin, Richard J.; Xiong, Chengjie; Gordon, Brian A.; Levey, Allan I.; Goate, Alison M.; Graff-Radford, Neill R.; Levin, Johannes; Dominantly Inherited Alzheimer Network (BMJ Publishing Group, 2022-12-15)
  • Latin America has been under-represented in dementia clinical trials, we must turn the corner 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-06-11)
    The world’s population is aging, life expectancy is increasing in the past century as result of the improvements in healthcare and the people arrive to live longer and healthier. However, this has also resulted in increase ...
  • Living with dementia: increased level of caregiver stress in times of COVID-19 
    Cohen, Gabriela; Russo, María Julieta; Campos, Jorge; Allegri, Ricardo Francisco (Cambridge University Press, 2020-11)
    COVID-19 pandemic in Argentina has affected the care of older adults with dementia deeply. Our objective was to study how the obligatory social isolation affected stress caregiver and burden of care of family members of ...
  • Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease 
    Joseph-Mathurin, Nelly; Wang, Guoquiao; Kantarci, Kejal; Jack Jr, Clifford R.; McDade, Eric; Hassenstab, Jason; Blazey, Tyler M.; Gordon, Brian A.; Su, Yi; Chen, Gengsheng; Massoumzadeh, Parinaz; Hornbeck, Russ C.; Allegri, Ricardo Francisco; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Dominantly Inherited Alzheimer Network (AAN, 2021-01-25)
    Objective: To investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds (CMBs) and characterize individuals at high risk for developing hemorrhagic ...
  • Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease 
    Llibre Guerra, Jorge J.; Iaccarino, Leonardo; Coble, Dean; Edwards, Lauren; Li, Yan; McDade, Eric; Strom, Amelia; Gordon, Brian; Mundada, Nidhi; Schindler, Suzanne E.; Tsoy, Elena; Ma, Yinjiao; Lu, Ruijin; Fagan, Anne M.; Benzinger, Tammie L. S.; Soleimani-Meigooni, David; Aschenbrenner, Andrew J.; Allegri, Ricardo Francisco; Patricio Alexis, Chrem Méndez; Surace, Ezequiel Ignacio (Oxford University Press, 2023-10-18)
    Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent to which ...

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