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ListarNeurología Cognitiva.artículos por tema "Alzheimer Disease"

ListarNeurología Cognitiva.artículos por tema "Alzheimer Disease"

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  • Loss of Direct Vascular Contact to Astrocytes in the Hippocampus as an Initial Event in Alzheimer's Disease. Evidence from Patients, In Vivo and In Vitro Experimental Models 
    Pomilio, Carlos; Presa, Jessica; Oses, Camila; Vinuesa, Ángeles; Bentivegna, Melisa; Gregosa, Amal; Riudavets, Miguel; Sevlever, Gustavo Emilio; Galvan, V.; Levi, V.; Beauquis, Juan; Saravia, Flavia (Humana Press, 2024-01-03)
    Alzheimer's disease (AD) is characterized by the accumulation of aggregated amyloid peptides in the brain parenchyma and within the walls of cerebral vessels. The hippocampus-a complex brain structure with a pivotal role ...
  • Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients 
    Pomilio, Carlos; Gorojod, Roxana M.; Riudavets, Miguel; Vinuesa, Ángeles; Presa, Jessica; Gregosa, Amal; Bentivegna, Melisa; Alaimo, Agustina; Porte Alcon, Soledad; Sevlever, Gustavo Emilio; Kotler, Monica L.; Beauquis, Juan; Saravia, Flavia (Springer, 2020-01-23)
    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the brain. Microglial cells are key players in ...
  • Moving from neurodegenerative dementias, to cognitive proteinopathies, replacing "where" by "what"… 
    Allegri, Ricardo Francisco (Associação Neurologia Cognitiva e do Comportamento, 2020-07)
    Neurodegenerative dementias have been described based on their phenotype, in relation to selective degeneration occurring in a particular neuroanatomical system. More recently however, the term proteinopathy has been ...
  • Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study 
    Millar, Peter R.; Gordon, Brian A.; Luckett, Patrick H.; Benzinger, Tammie L.S.; Cruchaga, Carlos; Fagan, Anne M.; Hassenstab, Jason; Perrin, Richard J.; Schindler, Suzanne E.; Allegri, Ricardo Francisco; Day, Gregory S.; Farlow, Martin R.; Mori, Hiroshi; Nübling, Georg; Dominantly Inherited Alzheimer Network; Bateman, Randall J.; Morris, John C.; Ances, Beau M. (eLife Sciences Publications, 2023-01-06)
    Background: Estimates of 'brain-predicted age' quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic ...
  • Neuroimaging within the Dominantly Inherited Alzheimer’s Network (DIAN): PET and MRI 
    McKay, Nicole S.; Gordon, Brian A.; Hornbeck, Russ C.; Jack, Clifford R.; Koeppe, Robert A.; Flores, Shaney; Keefe, Sarah J.; Hobbs, Diana, A.; Joseph-Mathurin, Nelly; Wang, Qing; Rahmani, Farzaneh; Chen, Charles D.; McCullough, Austin; Koudelis, Deborah; Chua, Jasmin; Ances, Beau M.; Millar, Peter R.; Nickels, Mike; Allegri, Ricardo Francisco; The Dominantly Inherited Alzheimer Network (bioRxiv, 2022-03-30)
    The Dominantly Inherited Alzheimer Network (DIAN) Observational Study is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). This rare form of Alzheimer disease (AD) is caused by mutations ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martín, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...
  • Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer's Disease 
    Fernández, Gerardo; González, Ana Paula; Abulafia, Carolina; Fiorentini, Leticia; Agamennoni, Osvaldo; Guinjoan, Salvador Martín (Bentham Science Publishers, 2022)
    Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and program the following saccade. ...
  • La Organización Mundial de la Salud acaba de lanzar un Blueprint for Dementia Research. Algunas notas para impulsar la investigación sobre la demencia en América Latina... 
    Allegri, Ricardo Francisco; Román, Fabián; Barceló Martínez, Ernesto (Universidad de la Costa, 2022-12-28)
    La demencia es la causa más importante de discapacidad y dependencia en los adultos mayores y actualmente afecta a más de 55 millones de personas, el 60% de las cuales vive en países de ingresos bajos y medios (PRMB). El ...
  • Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid 
    Drieu, Antoine; Du, Siling; Storck, Steffen E.; Rustenhoven, Justin; Papadopoulos, Zachary; Dykstra, Taitea; Zhong, Fenghe; Kim, Kyungdeok; Blackburn, Susan; Mamuladze, Tornike; Harari, Oscar; Karch, Celeste M.; Bateman, Randall J.; Perrin, Richard J.; Farlow, Martin R.; Chhatwal, Jasmeer; Dominantly Inherited Alzheimer Network; Hu, Song; Randolph, Gwendalyn J.; Allegri, Ricardo Francisco (Nature Publishing Group, 2022-11)
    Macrophages are important players in the maintenance of tissue homeostasis1. Perivascular and leptomeningeal macrophages reside near the central nervous system (CNS) parenchyma2, and their role in CNS physiology has not ...
  • Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus 
    Čarna, Maria; Onyango, Isaac G.; Katina, Stanislav; Holub, Dušan; Novotny, Jan Sebastian; Nezvedova, Marketa; Jha, Durga; Nedelska, Zuzana; Lacovich, Valentina; Vande Vyvere, Thijs; Houbrechts, Ruben; Garcia-Mansfield, Krystine; Sharma, Ritin; David-Dirgo, Victoria; Vyhnalek, Martin; Texlova, Kateřina; Chaves, Hernán; Bakkar, Nadine; Pertierra, Lucía; Sevlever, Gustavo Emilio (Wiley, 2023-02-24)
    The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation ...
  • Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease 
    Keret, Ophir; Staffaroni, Adam M.; Ringman, John M.; Cobigo, Yann; Goh, Sheng-Yang M.; Wolf, Amy; Allen, Isabel Elaine; Salloway, Stephen; Chhatwal, Jasmeer P.; Brickman, Adam M.; Reyes-Dumeyer, Dolly; Bateman, Randall J.; Benzinger, Tammie L.S.; Morris, John C.; Ances, Beau M.; Joseph-Mathurin, Nelly; Perrin, Richard J.; Gordon, Brian A.; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis (Wiley, 2021-07-05)
    Introduction Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. ...
  • Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease 
    Vöglein, Jonathan; Franzmeier, Nicolai; Morris, John C.; Dieterich, Marianne; McDade, Eric; Simon, Mikael; Preische, Oliver; Hofmann, Anna; Hassenstab, Jason; Benzinger, Tammie L.S.; Fagan, Anne M.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2022-05-24)
    Introduction: As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ...
  • Performance on the Latin American version of the Face-Name Associative Memory Exam (LAS-FNAME) distinguishes individuals with Mild Cognitive Impairment from age-matched controls in a sample from Argentina. 
    Keller, Greta; Corvalán, Nicolás; Carello, María Agostina; Arruabarrena, Micaela María; Martínez Canyazo, Carlos; De Los Santos, Loana; Spehrs, Julieta; Vila-Castelar, Clara; Allegri, Ricardo Francisco; Quiroz, Yakeel T.; Crivelli, Lucía (Taylor & Francis, 2024-03-06)
    Introduction: The Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) has shown promise in identifying cognitive changes in those at risk for Alzheimer's disease (AD). However, its applicability ...
  • Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN) 
    McKay, Nicole S.; Gordon, Brian A.; Hornbeck, Russ C.; Dincer, Aylin; Flores, Shaney; Keefe, Sarah J.; Joseph-Mathurin, Nelly; Jack, Clifford R.; Koeppe, Robert; Millar, Peter R.; Ances, Beau M.; Chen, Charles D.; Daniels, Alisha; Hobbs, Diana A.; Jackson, Kelley; Koudelis, Deborah; Massoumzadeh, Parinaz; McCullough, Austin; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2023-07-10)
    The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families ...
  • Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease 
    Millar, Peter R.; Luckett, Patrick H.; Gordon, Brian A.; Benzinger, Tammie L.S.; Schindler, Suzanne E.; Fagan, Anne M.; Cruchaga, Carlos; Bateman, Randall J.; Allegri, Ricardo Francisco; Jucker, Mathias; Lee, Jae-Hong; Mori, Hiroshi; Salloway, Stephen; Igor, Yakushev; Morris, John C.; Ances, Beau M.; Dominantly Inherited Alzheimer Network (Academic Press, 2022-08-01)
    "Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories. Advanced brain-predicted age has been well established in symptomatic Alzheimer disease (AD), but is underexplored in ...
  • Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage 
    Joseph-Mathurin, Nelly; Feldman, Rebecca L.; Lu, Ruijin; Shirzadi, Zahra; Toomer, Carmen; Saint Clair, Junie R.; Ma, Yinjiao; McKay, Nicole S.; Strain, Jeremy F.; Kilgore, Collin; Friedrichsen, Karl A.; Chen, Charles D.; Gordon, Brian A.; Chen, Gengsheng; Hornbeck, Russ C.; Massoumzadeh, Parinaz; McCullough, Austin A.; Wang, Qing; Li, Yan; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (John Wiley & Sons, 2024-02-21)
    Introduction: Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated ...
  • Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer’s Disease Neuroimaging Initiative. 
    Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Calandri, Ismael Luis; Cohen, Gabriela; Martín, María Eugenia; Russo, María Julieta; Crivelli, Lucía; Pertierra, Lucía; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Vázquez, Silvia; Surace, Ezequiel Ignacio; Sevlever, Gustavo Emilio (Elsevier, 2020)
    Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer’s Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients ...
  • Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease 
    Ewers, Michael; Luan, Ying; Frontzkowski, Lukas; Neitzel, Julia; Rubinski, Anna; Dichgans, Martin; Hassenstab, Jason; Gordon, Brian A.; Chhatwal, Jasmeer P.; Levin, Johannes; Schofield, Peter R.; Benzinger, Tammie L.S.; Morris, John C.; Goate, Alison M.; Karch, Celeste M.; Fagan, Anne M.; McDade, Eric; Allegri, Ricardo Francisco; Berman, Sarah B.; Chui, Helena C. (Oxford, 2021-03-16)
    Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal ...
  • Seizures as an early symptom of autosomal dominant Alzheimer's disease 
    Vöglein, Jonathan; Noachtar, Soheyl; McDade, Eric; Quaid, Kimberly A.; Salloway, Stephen; Ghetti, Bernardino; Noble, James M.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Mori, Hiroshi; Fox, Nick C.; Allegri, Ricardo Francisco; Masters, Colin L.; Buckles, Virginia; Ringman, John M.; Rossor, Martin N.; Schofield, Peter R.; Sperling, Reisa; Jucker, Mathias; Dominantly Inherited Alzheimer Network (Elsevier, 2018-12-05)
    Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status ...
  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease 
    Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph N.; Schofield, Peter R.; Rossor, Martin N.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-01-21)
    Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ...

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