ListarNeurología Cognitiva.artículos por tema "Cell Biology"

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CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease

Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John; Do, Anh; Liu, Haiyan; Gordon, Brian; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Hernández, Damián; Morgan Schlicht, Stephanie; Clarke, Jordan Elli; Daniszewski, Maciej; Karch, Celeste M.; Dominantly Inherited Alzheimer Network; Goate, Alison M.; Pébay, Alice; Allegri, Ricardo Francisco (Elsevier, 2024-09)

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem ...

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