ListarNeurología Cognitiva.artículos por tema "Microglia"

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CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease

Shen, Yuanyuan; Timsina, Jigyasha; Heo, Gyujin; Beric, Aleksandra; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wang, Yueyao; Western, Daniel; Liu, Menghan; Gorijala, Priyanka; Budde, John; Do, Anh; Liu, Haiyan; Gordon, Brian; Llibre Guerra, Jorge J.; Surace, Ezequiel Ignacio; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network (Cell Press, 2024-09-26)

In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF ...
Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients

Pomilio, Carlos; Gorojod, Roxana M.; Riudavets, Miguel; Vinuesa, Ángeles; Presa, Jessica; Gregosa, Amal; Bentivegna, Melisa; Alaimo, Agustina; Porte Alcon, Soledad; Sevlever, Gustavo Emilio; Kotler, Mónica L.; Beauquis, Juan; Saravia, Flavia (Springer, 2020-01-23)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the brain. Microglial cells are key players in ...

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