Neurología Cognitiva.artículos: Recent submissions

  • La investigación y los investigadores clínicos continúan huérfanos en el sistema nacional de ciencia y técnica… 
    Allegri, Ricardo Francisco (Fundación Revista Medicina (Buenos Aires), 2020-07)
  • Resiliencia de docentes en distanciamiento social preventivo obligatorio durante la pandemia de COVID-19 
    Román, Fabián; Forés Miravalles, Anna; Calandri, Ismael Luis; Gautreaux, Rosalba; Antúnez, Alejandro; Ordhei, Dalul; Calle, Lenin; Poenitz, Victoria; Correa Pérez, Kethy Luz; Torresi, Sandra; Barceló Martínez, Ernesto; Conejo, Mauricio; Ponnet, Veerle; Allegri, Ricardo Francisco (Universitat de Barcelona, 2021)
    a situación de pandemia por COVID-19 motivó en todos los países la adopción de medidas extremas para evitar la propagación del virus. El cierre de escuelas, colegios y universidades cambió sorpresiva y radicalmente las ...
  • Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease 
    Joseph-Mathurin, Nelly; Wang, Guoqiao; Kantarci, Kejal; Jack Jr, Clifford R.; McDade, Eric; Hassenstab, Jason; Blazey, Tyler M.; Gordon, Brian A.; Su, Yi; Chen, Gengsheng; Massoumzadeh, Parinaz; Hornbeck, Russ C.; Allegri, Ricardo Francisco; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Dominantly Inherited Alzheimer Network (AAN, 2021-01-25)
    Objective: To investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds (CMBs) and characterize individuals at high risk for developing hemorrhagic ...
  • White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease 
    Sánchez, Stella Maris; Duarte-Abritta, Bárbara; Abulafia, Carolina; De Pino, Gabriela; Bocaccio, Hernán; Castro, Mariana Nair; Sevlever, Gustavo Emilio; Fonzo, Greg A.; Nemeroff, Charles B.; Gustafson, Deborah R.; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2020-02)
    Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
  • Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients 
    Pomilio, Carlos; Gorojod, Roxana M.; Riudavets, Miguel; Vinuesa, Ángeles; Presa, Jessica; Gregosa, Amal; Bentivegna, Melisa; Alaimo, Agustina; Porte Alcon, Soledad; Sevlever, Gustavo Emilio; Kotler, Mónica L.; Beauquis, Juan; Saravia, Flavia (Springer, 2020-01-23)
    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the brain. Microglial cells are key players in ...
  • Seizures as an early symptom of autosomal dominant Alzheimer's disease 
    Vöglein, Jonathan; Noachtar, Soheyl; McDade, Eric; Quaid, Kimberly A.; Salloway, Stephen; Ghetti, Bernardino; Noble, James M.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Mori, Hiroshi; Fox, Nick C.; Allegri, Ricardo Francisco; Masters, Colin L.; Buckles, Virginia; Ringman, John M.; Rossor, Martin N.; Schofield, Peter R.; Sperling, Reisa; Jucker, Mathias; Dominantly Inherited Alzheimer Network (Elsevier, 2018-12-05)
    Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status ...
  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease 
    Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph N.; Schofield, Peter R.; Rossor, Martin N.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-01-21)
    Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations 
    Dube, Umber; Del-Aguila, Jorge L.; Li, Zeran; Budde, John P.; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L.; Lee, Jae-Hong; Graff-Radford, Neill R.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-10-07)
    Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martín, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease 
    Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...
  • Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN) 
    Aschenbrenner, Andrew J.; James, Bryan D.; McDade, Eric; Wang, Guoqiao; Lim, Yen Ying; Benzinger, Tammie L.S.; Cruchaga, Carlos; Goate, Alison M.; Xiong, Chengjie; Perrin, Richard J.; Buckles, Virginia; Allegri, Ricardo Francisco; Berman, Sarah B.; Chhatwal, Jasmeer P.; Fagan, Anne M.; Farlow, Martin R.; O’Connor, Antoinette; Ghetti, Bernardino; Graff-Radford, Neill R.; Goldman, Jill; Gräber, Susanne; Karch, Celeste M.; Lee, Jae-Hong; Levin, Johannes; Martins, Ralph N.; Masters, Colin L.; Mori, Hiroshi; Noble, James M.; Salloway, Stephen; Schofield, Peter R.; Morris, John C.; Bateman, Randall J.; Hassenstab, Jason; Dominantly Inherited Alzheimer Network; Dominantly Inherited Alzheimer Network (Wiley, 2020-06)
    Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is ...
  • Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer’s Disease Neuroimaging Initiative. 
    Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Calandri, Ismael Luis; Cohen, Gabriela; Martín, María Eugenia; Russo, María Julieta; Crivelli, Lucía; Pertierra, Lucía; Tapajóz Pereira de Sampaio, Fernanda; Clarens, María Florencia; Campos, Jorge; Nahas, Federico Ezequiel; Vázquez, Silvia; Surace, Ezequiel Ignacio; Sevlever, Gustavo Emilio (Elsevier, 2020)
    Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer’s Disease Neuroimaging Initiative (arg-ADNI) cohort. Methods: Twenty-three patients ...
  • Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease 
    Vöglein, Jonathan; Paumier, Katrina; Jucker, Mathias; Preische, Oliver; McDade, Eric; Hassenstab, Jason; Benzinger, Tammie L.S.; Noble, James M.; Berman, Sarah B.; Graff-Radford, Neill R.; Ghetti, Bernardino; Farlow, Martin R.; Chhatwal, Jasmeer P.; Salloway, Stephen; Xiong, Chengjie; Karch, Celeste M.; Cairns, Nigel; Mori, Hiroshi; Schofield, Peter R.; Masters, Colin L.; Goate, Alison M.; Buckles, Virginia; Fox, Nick C.; Rossor, Martin N.; Chrem Méndez, Patricio Alexis; Allegri, Ricardo Francisco; Ringman, John M.; Höglinger, Günter U.; Steiner, Harald; Dieterich, Marianne; Haass, Christian; Laske, Christoph; Morris, John C.; Bateman, Randall J.; Danek, Adrian; Levin, Johannes; Dominantly Inherited Alzheimer Network (Oxford, 2019-03-20)
    Owing to an early and marked deposition of amyloid-β in the basal ganglia, autosomal dominant Alzheimer’s disease could distinctly involve motor symptoms. Therefore, we aimed to assess the prevalence and characteristics ...
  • Medición del entrenamiento musical como indicador de reserva cognitiva: adaptación y validación de la versión argentina del Musical Training Questionnaire 
    Feldberg, Carolina; Stefani, Dorina; Moya García, Lydia; Mailing, Ingrid; Caruso, Guido; Somale, María Verónica; Allegri, Ricardo Francisco (Sociedad Neurológica Argentina, 2019-02-04)
    Introducción La participación en actividades del tiempo libre, especialmente el entrenamiento musical, puede ser un posible indicador de la reserva cognitiva (RC) del sujeto. La relevancia de su estudio consiste en ...
  • Biomarkers for Alzheimer's Disease. Where We Stand and Where We Are Headed 
    Chrem Méndez, Patricio Alexis; Surace, Ezequiel Ignacio; Bérgamo, Yanina; Calandri, Ismael Luis; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Fundación Revista Medicina, 2019-06-10)
    Alzheimer disease (AD) is one of the major unresolved health burdens accompanying the increase in life expectancy. The great paradigm shift for this disease has resulted from finding amyloid deposition and neurobrillary ...
  • Escala de detección de olvidos. Una herramienta de rastrillaje para el deterioro cognitivo leve 
    Cerviño, Cecilia; Crivelli, Lucía; Calandri, Ismael Luis; Allegri, Ricardo Francisco (Universidad de Montreal, 2019-12-30)
    En los últimos años han incrementado las consultas por fallas de memoria, dado que ha aumentado la expectativa de vida. La prevalencia de trastornos mnésicos en la edad adulta, requiere instrumentos de rastrillaje sensibles, ...
  • Transient global amnesia: clinical features and prognostic factors suggesting recurrence 
    Alessandro, Lucas; Calandri, Ismael Luis; Fernández Suárez, Marcos; Heredia, María Liliana; Chaves, Hernán; Allegri, Ricardo Francisco; Farez, Mauricio Franco (Associacao Arquivos De Neuro-Psiquitria, 2019-01)
    Objective: The risk of recurrence of new amnesia events in patients having previously experienced transient global amnesia (TGA) ranges between 2.9-23.8%. Our objective was to search for recurrence predictors in TGA ...
  • Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients 
    Abulafia, Carolina; Fiorentini, Leticia; Loewenstein, David A.; Curiel-Cid, Rosie; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Villarreal, Mirta Fabiana; Vigo, Daniel Eduardo; Guinjoan, Salvador Martín (Oxford, 2019-02-22)
    Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions ...
  • A novel mutation in PSEN1 (p.T119I) in an Argentine family with early- and late-onset Alzheimer's disease 
    Itzcovich, Tatiana; Chrem Méndez, Patricio Alexis; Vázquez, Silvia; Barbieri-Kennedy, Micaela; Niikado, Matías; Martinetto, Horacio; Allegri, Ricardo Francisco; Sevlever, Gustavo Emilio; Surace, Ezequiel Ignacio (Elsevier, 2020-01)
    Mutations inPSEN1are the most common cause of early-onset Alzheimer’s disease (AD). In this article,we present an Argentine family with autosomal dominant early- and late-onset AD. The proband and 6family members were ...

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