Neurología Cognitiva.artículos: Recent submissions

  • Living with dementia: increased level of caregiver stress in times of COVID-19 
    Cohen, Gabriela; Russo, María Julieta; Campos, Jorge; Allegri, Ricardo Francisco (Cambridge University Press, 2020-11)
    COVID-19 pandemic in Argentina has affected the care of older adults with dementia deeply. Our objective was to study how the obligatory social isolation affected stress caregiver and burden of care of family members of ...
  • Utility of a Spanish version of Three Words-Three Shapes Test to detect memory impairment in primary progressive aphasia 
    Calandri, Ismael Luis; Crivelli, Lucía; Morello García, Florentina; Allegri, Ricardo Francisco (Taylor & Frances, 2021-04-09)
    Introduction: Three Words-Three Shapes (3W3S) is a bedside test that assesses verbal and non-verbal memory and has proven useful in staging memory decline in amnestic disorders and primary progressive aphasia. Given its ...
  • COVID-19 Epidemic in Argentina: Worsening of Behavioral Symptoms in Elderly Subjects With Dementia Living in the Community 
    Cohen, Gabriela; Russo, María Julieta; Campos, Jorge; Allegri, Ricardo Francisco (Frontiers Research Foundation, 2020-08-28)
    In Argentina, the quality of care that elderly subjects with dementia living in the community received has been deeply affected by COVID-19 epidemic. Our objective was to study to what extend mandatory quarantine imposed ...
  • Utility of a Screening Test (MoCa) to Predict Amyloid Physiopathology in Mild Cognitive Impairment 
    Clarens, María Florencia; Calandri, Ismael Luis; Helou, María Belén; Martín, María Eugenia; Chrem Méndez, Patricio Alexis; Crivelli, Lucía (Universidad de la Costa, 2020-11-09)
    Introduction: The MoCa (Montreal Cognitive Assessment) Screening test has become relevant in recent years in the screening of patients with Mild Cognitive Impairment (MCI). It is important to seek and study simple and ...
  • Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer's disease in Colombia 
    Porto, Maria F.; Benitez Agudelo, Juan Camilo; Aguirre Acevedo, Daniel Camilo; Barceló Martínez, Ernesto; Allegri, Ricardo Francisco (Taylor & Francis, 2021-03-24)
    Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. ...
  • Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease 
    Ewers, Michael; Luan, Ying; Frontzkowski, Lukas; Neitzel, Julia; Rubinski, Anna; Dichgans, Martin; Hassenstab, Jason; Gordon, Brian A.; Chhatwal, Jasmeer P.; Levin, Johannes; Schofield, Peter R.; Benzinger, Tammie L.S.; Morris, John C.; Goate, Alison M.; Karch, Celeste M.; Fagan, Anne M.; McDade, Eric; Allegri, Ricardo Francisco; Berman, Sarah B.; Chui, Helena C. (Oxford, 2021-03-16)
    Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal ...
  • Environmental factors between normal and superagers in an Argentine cohort 
    Calandri, Ismael Luis; Crivelli, Lucía; Martin, María Eugenia; Egido, Noelia; Magrath Guimet, Nahuel (Associação Neurologia Cognitiva e do Comportamento, 2020-12-14)
    Normal aging usually brings age-related cognitive decline. However, there is a group of aged individuals who have exceptional memory performance: the superagers. Objective: Our aim was to identify the environmental ...
  • The impact of an early strict nationwide lockdown on the pattern of consultation for neurological diseases 
    Calandri, Ismael Luis; Hawkes, Maximiliano Alberto; Marrodán, Mariano; Ameriso, Sebastián Francisco; Allegri, Ricardo Francisco (Elsevier, 2020-10-15)
  • Moving from neurodegenerative dementias, to cognitive proteinopathies, replacing "where" by "what"… 
    Allegri, Ricardo Francisco (Associação Neurologia Cognitiva e do Comportamento, 2020-07)
    Neurodegenerative dementias have been described based on their phenotype, in relation to selective degeneration occurring in a particular neuroanatomical system. More recently however, the term proteinopathy has been ...
  • La investigación y los investigadores clínicos continúan huérfanos en el sistema nacional de ciencia y técnica… 
    Allegri, Ricardo Francisco (Fundación Revista Medicina (Buenos Aires), 2020-07)
  • Resiliencia de docentes en distanciamiento social preventivo obligatorio durante la pandemia de COVID-19 
    Román, Fabián; Forés Miravalles, Anna; Calandri, Ismael Luis; Gautreaux, Rosalba; Antúnez, Alejandro; Ordhei, Dalul; Calle, Lenin; Poenitz, Victoria; Correa Pérez, Kethy Luz; Torresi, Sandra; Barceló Martínez, Ernesto; Conejo, Mauricio; Ponnet, Veerle; Allegri, Ricardo Francisco (Universitat de Barcelona, 2021)
    a situación de pandemia por COVID-19 motivó en todos los países la adopción de medidas extremas para evitar la propagación del virus. El cierre de escuelas, colegios y universidades cambió sorpresiva y radicalmente las ...
  • Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease 
    Joseph-Mathurin, Nelly; Wang, Guoqiao; Kantarci, Kejal; Jack Jr, Clifford R.; McDade, Eric; Hassenstab, Jason; Blazey, Tyler M.; Gordon, Brian A.; Su, Yi; Chen, Gengsheng; Massoumzadeh, Parinaz; Hornbeck, Russ C.; Allegri, Ricardo Francisco; Ances, Beau M.; Berman, Sarah B.; Brickman, Adam M.; Brooks, William S.; Cash, David M.; Chhatwal, Jasmeer P.; Dominantly Inherited Alzheimer Network (AAN, 2021-01-25)
    Objective: To investigate the inherent clinical risks associated with the presence of cerebral microhemorrhages (CMHs) or cerebral microbleeds (CMBs) and characterize individuals at high risk for developing hemorrhagic ...
  • White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease 
    Sánchez, Stella Maris; Duarte-Abritta, Bárbara; Abulafia, Carolina; De Pino, Gabriela; Bocaccio, Hernán; Castro, Mariana Nair; Sevlever, Gustavo Emilio; Fonzo, Greg A.; Nemeroff, Charles B.; Gustafson, Deborah R.; Guinjoan, Salvador Martín; Villarreal, Mirta Fabiana (Elsevier, 2020-02)
    Tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset Alzheimer's disease (LOAD). There is a need to ascertain methods for the detection of early LOAD features to help with ...
  • Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients 
    Pomilio, Carlos; Gorojod, Roxana M.; Riudavets, Miguel; Vinuesa, Ángeles; Presa, Jessica; Gregosa, Amal; Bentivegna, Melisa; Alaimo, Agustina; Porte Alcon, Soledad; Sevlever, Gustavo Emilio; Kotler, Mónica L.; Beauquis, Juan; Saravia, Flavia (Springer, 2020-01-23)
    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the brain. Microglial cells are key players in ...
  • Seizures as an early symptom of autosomal dominant Alzheimer's disease 
    Vöglein, Jonathan; Noachtar, Soheyl; McDade, Eric; Quaid, Kimberly A.; Salloway, Stephen; Ghetti, Bernardino; Noble, James M.; Berman, Sarah B.; Chhatwal, Jasmeer P.; Mori, Hiroshi; Fox, Nick C.; Allegri, Ricardo Francisco; Masters, Colin L.; Buckles, Virginia; Ringman, John M.; Rossor, Martin N.; Schofield, Peter R.; Sperling, Reisa; Jucker, Mathias; Dominantly Inherited Alzheimer Network (Elsevier, 2018-12-05)
    Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status ...
  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease 
    Preische, Oliver; Schultz, Stephanie A.; Apel, Anja; Kuhle, Jens; Kaeser, Stephan A.; Barro, Christian; Gräber-Sultan, Susanne; Kuder-Buletta, Elke; LaFougere, Christian; Laske, Christoph; Vöglein, Jonathan; Levin, Johannes; Masters, Colin L.; Martins, Ralph N.; Schofield, Peter R.; Rossor, Martin N.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-01-21)
    Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ...
  • Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease 
    Del Cerro, Inés; Villarreal, Mirta Fabiana; Abulafia, Carolina; Duarte-Abritta, Bárbara; Sánchez, Stella Maris; Castro, Mariana Nair; Bocaccio, Hernán; Ferrer, Isidre; Menchón, José Manuel; Sevlever, Gustavo Emilio; Nemeroff, Charles B.; Soriano-Mas, Carles; Guinjoan, Salvador Martín (Pergamon Press, 2020-04)
    Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays ...
  • An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations 
    Dube, Umber; Del-Aguila, Jorge L.; Li, Zeran; Budde, John P.; Jiang, Shan; Hsu, Simon; Ibanez, Laura; Fernandez, Maria Victoria; Farias, Fabiana; Norton, Joanne; Gentsch, Jen; Wang, Fengxian; Salloway, Stephen; Masters, Colin L.; Lee, Jae-Hong; Graff-Radford, Neill R.; Dominantly Inherited Alzheimer Network (Nature Publishing Group, 2019-10-07)
    Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and ...
  • Neuropsychological profile of Alzheimer’s disease based on amyloid biomarker findings results from a South American cohort. Appl Neuropsychol Adult 1–6. 
    Clarens, María Florencia; Crivelli, Lucía; Calandri, Ismael Luis; Chrem Méndez, Patricio Alexis; Martín, María Eugenia; Russo, María Julieta; Campos, Jorge; Surace, Ezequiel Ignacio; Vázquez, Silvia; Sevlever, Gustavo Emilio; Allegri, Ricardo Francisco (Taylor & Francis Group, 2020-04-30)
    Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing ...
  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease 
    Barthélemy, Nicolas R.; Li, Yan; Joseph-Mathurin, Nelly; Gordon, Brian A.; Hassenstab, Jason; Benzinger, Tammie L.S.; Buckles, Virginia; Fagan, Anne M.; Perrin, Richard J.; Goate, Alison M.; Morris, John C.; Karch, Celeste M.; Xiong, Chengjie; Allegri, Ricardo Francisco; Chrem Méndez, Patricio Alexis; Berman, Sarah B.; Ikeuchi, Takeshi; Mori, Hiroshi; Shimada, Hiroyuki; Shoji, Mikio; Suzuki, Kazushi; Noble, James M.; Farlow, Martin R.; Chhatwal, Jasmeer P.; Graff-Radford, Neill R.; Salloway, Stephen; Schofield, Peter R.; Masters, Colin L.; Martins, Ralph N.; O’Connor, Antoinette; Fox, Nick C.; Levin, Johannes; Jucker, Mathias; Gabelle, Audrey; Lehmann, Sylvain; Sato, Chihiro; Bateman, Randall J.; McDade, Eric; Dominantly Inherited Alzheimer Network (Nature, 2020-03)
    Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal ...

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