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Seizures as an early symptom of autosomal dominant Alzheimer's disease

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dc.contributor.author Vöglein, Jonathan
dc.contributor.author Noachtar, Soheyl
dc.contributor.author McDade, Eric
dc.contributor.author Quaid, Kimberly A.
dc.contributor.author Salloway, Stephen
dc.contributor.author Ghetti, Bernardino
dc.contributor.author Noble, James M.
dc.contributor.author Berman, Sarah B.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Mori, Hiroshi
dc.contributor.author Fox, Nick C.
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Masters, Colin L.
dc.contributor.author Buckles, Virginia
dc.contributor.author Ringman, John M.
dc.contributor.author Rossor, Martin N.
dc.contributor.author Schofield, Peter R.
dc.contributor.author Sperling, Reisa
dc.contributor.author Jucker, Mathias
dc.contributor.author Dominantly Inherited Alzheimer Network
dc.date.accessioned 2020-12-09T14:24:15Z
dc.date.available 2020-12-09T14:24:15Z
dc.date.issued 2018-12-05
dc.identifier.citation Vöglein, J., Noachtar, S., McDade, E., Quaid, K.A., Salloway, S., Ghetti, B., Noble, J., Berman, S., Chhatwal, J., Mori, H., Fox, N., Allegri, R., Masters, C.L., Buckles, V., Ringman, J.M., Rossor, M., Schofield, P.R., Sperling, R., Jucker, M., Laske, C., Paumier, K., Morris, J.C., Bateman, R.J., Levin, J., Danek, A., Dominantly Inherited Alzheimer Network. Seizures as an early symptom of autosomal dominant Alzheimer’s disease. Neurobiol. Aging 2019;76:18–23. doi:10.1016/j.neurobiolaging.2018.11.022 en_US
dc.identifier.uri https://doi.org/10.1016/j.neurobiolaging.2018.11.022
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/255
dc.description.abstract Our objective was to assess the reported history of seizures in cognitively asymptomatic mutation carriers for autosomal dominant Alzheimer's disease (ADAD) and the predictive value of seizures for mutation carrier status in cognitively asymptomatic first-degree relatives of ADAD patients. Seizure occurrence in the Dominantly Inherited Alzheimer Network observational study was correlated with mutation carrier status in cognitively asymptomatic subjects. Of 276 cognitively asymptomatic individuals, 11 (4%) had experienced seizures, and nine of these carried an ADAD mutation. Thus, in the Dominantly Inherited Alzheimer Network population, seizure frequency in mutation carriers was significantly higher than in noncarriers (p = 0.04), and the positive predictive value of seizures for the presence of a pathogenic mutation was 81.8%. Among cognitively asymptomatic ADAD family members, the occurrence of seizures increases the a priori risk of 50% mutation-positive status to about 80%. This finding suggests that ADAD mutations increase the risk of seizures. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease en_US
dc.subject Enfermedad de Alzheimer en_US
dc.subject Genetic Association Studies en_US
dc.subject Estudios de Asociación Genética en_US
dc.subject Seizures en_US
dc.subject Convulsiones en_US
dc.subject Predictive Value of Tests en_US
dc.subject Valor Predictivo de las Pruebas en_US
dc.title Seizures as an early symptom of autosomal dominant Alzheimer's disease en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Vöglein, Jonathan. German Center for Neurodegenerative Diseases; Alemania.
dc.description.fil Fil: Noachtar, Soheyl. Ludwig-Maximilians-Universität München; Alemania.
dc.description.fil Fil: McDade, Eric. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Quaid, Kimberly A. Indiana University; Estados Unidos.
dc.description.fil Fil: Salloway, Stephen. Butler Hospital; Estados Unidos.
dc.description.fil Fil: Ghetti, Bernardino. Indiana University School of Medicine; Estados Unidos.
dc.description.fil Fil: Noble, James M. Columbia University; Estados Unidos.
dc.description.fil Fil: Berman, Sarah B. University of Pittsburgh; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Mori, Hiroshi. Osaka City University Medical School; Japón.
dc.description.fil Fil: Fox, Nick C. University College London; Reino Unido.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Masters, Colin L. University of Melbourne; Australia.
dc.description.fil Fil: Buckles, Virginia. Washington University School of Medicine; Estados Unidos.
dc.description.fil Fil: Ringman, John M. Keck School of Medicine of University of Southern California; Estados Unidos.
dc.description.fil Fil: Rossor, Martin N. University College London; Reino Unido.
dc.description.fil Fil: Schofield, Peter R. Neuroscience Research Australia; Australia.
dc.description.fil Fil: Sperling, Reisa. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Jucker, Mathias. German Center for Neurodegenerative Diseases; Alemania.
dc.relation.ispartofVOLUME 76
dc.relation.ispartofPAGINATION 18-23
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Nueva York
dc.relation.ispartofTITLE Neurobiology of aging
dc.relation.ispartofISSN 1558-1497
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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