Enfermedades Desmielinizantes: Recent submissions

Anzeige der Dokumente 21-40 von 140

Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry

Carnero Contentti, Edgar; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Cristiano, Edgardo; Patrucco, Liliana; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Menichini, María Laura; Tavolini, Darío (Sage, 2023-10-17)

We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) ...
A plain language summary on assessing the long-term effectiveness of cladribine tablets in people living with relapsing multiple sclerosis: The CLASSIC-MS study

Giovannoni, Gavin; Boyko, Alexey; Correale, Jorge; Edan, Gilles; Freedman, Mark S.; Montalban, Xavier; Rammohan, Kottil; Stefoski, Dusan; Yamout, Bassem; Leist, Thomas; Aydemir, Aida; Borsi, Laszlo; Verdun di Cantogno, Elisabetta (Future Medicine, 2023-08-03)

What is this summary about?: Previous studies have shown that people living with multiple sclerosis (MS) treated with cladribine tablets have fewer relapses (where new symptoms occur or existing symptoms get worse for 24 ...
Microglia-derived extracellular vesicles in homeostasis and demyelination/remyelination processes

Wies Mancini, Victoria Sofía Berenice; Mattera, Vanesa S.; Pasquini, Juana María; Pasquini, Laura Andrea; Correale, Jorge (Wiley on behalf of the International Society for Neurochemistry, 2023-12-06)

Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous system and are commonly activated in multiple sclerosis. They perform essential functions under normal conditions, such as actively ...
Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina

Carnero Contentti, Edgar; López, Pablo Adrián; Pappolla, Agustín; Alonso, Ricardo; Silva, Berenice Anabel; Deri, Norma; Balbuena Aguirre, María Eugenia; Burgos, Marcos; Luetic, Geraldine G.; Alvez Pinheiro, Amelia; Cabrera, Mariela; Hryb, Javier Pablo; Nofal, Pedro G.; Pestchanker, Claudia; Vrech, Carlos; Tavolini, Darío; Marrodán, Mariano; Ysrraelit, María Célica; Correale, Jorge; RelevarEM investigators (Springer-Verlag Italia, 2023-12-30)

We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina ...
Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease

Shirzadi, Zahra; Schultz, Stephanie A.; Yau, Wai-Ying W.; Joseph-Mathurin, Nelly; Fitzpatrick, Colleen D.; Levin, Raina; Kantarci, Kejal; Preboske, Gregory M.; Jack Jr, Clifford R.; Farlow, Martin R.; Hassenstab, Jason; Jucker, Mathias; Morris, John C.; Xiong, Chengjie; Karch, Celeste M.; Levey, Allan I.; Gordon, Brian A.; Schofield, Peter R.; Allegri, Ricardo Francisco; Dominantly Inherited Alzheimer Network; Alzheimer’s Disease Neuroimaging Initiative (American Medical Association, 2023-12-01)

Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains ...
Clinical characterization of long-term multiple sclerosis (COLuMbus) patients in Argentina: A cross-sectional non-interventional study

Deri, Norma; Barboza, Andrés G.; Vrech, Carlos; Rey, Roberto D.; Burgos, Marcos; Fiol, Marcela Paula; Calvo Vildoso, Christian; Patrucco, Liliana; José, Gustavo; Aliberti, Paula; Chirico, Daniela; Federico, María B.; Seifer, Gustavo; Piedrabuena, Raúl (Elsevier, 2023-12-31)

Background: Most Multiple Sclerosis (MS) clinical trials fail to assess the long-term effects of disease-modifying therapies (DMT) or disability. Methods: COLuMbus was a single-visit, cross-sectional study in Argentina ...
Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting

Carnero Contentti, Edgar; López, Pablo Adrián; Tkachuk, Verónica A.; Vrech, Carlos; Zarate, María Agustina; Correale, Jorge; Deri, Norma; Luetic, Geraldine G.; Marrodán, Mariano; Pagani Cassará, Fátima; Tavolini, Darío; Ysrraelit, María Célica; Balbuena Aguirre, María Eugenia; Hryb, Javier Pablo; Chiganer, Edson Hernán; Leguizamon, Felisa; Knorre, Eduardo; Zanga, Gisela; Pestchanker, Claudia; Barboza, Andrés G. (Sage, 2023-07-25)

Background: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis ...
Differential diagnosis of suspected multiple sclerosis: an updated consensus approach

Solomon, Andrew J.; Arrambide, Georgina; Brownlee, Wallace J.; Flanagan, Eoin P.; Amato, María Pía; Amezcua, Lilyana; Banwell, Brenda L.; Barkhof, Frederik; Corboy, John R.; Correale, Jorge; Fujihara, Kazuo; Graves, Jennifer; Harnegie, Mary Pat; Hemmer, Bernhard; Lechner-Scott, Jeannette; Marrie, Ruth Ann; Newsome, Scott D.; Rocca, Maria A.; Royal, Walter; Waubant, Emmanuelle L. (Lancet, 2023-07-19)

Accurate diagnosis of multiple sclerosis requires careful attention to its differential diagnosis-many disorders can mimic the clinical manifestations and paraclinical findings of this disease. A collaborative effort, ...
Global Barriers to the Diagnosis of Multiple Sclerosis: Data From the Multiple Sclerosis International Federation Atlas of MS, Third Edition

Solomon, Andrew J.; Marrie, Ruth Ann; Viswanathan, Shanthi; Correale, Jorge; Magyari, Melinda; Robertson, Neil P.; Saylor, Deanna R.; Kaye, Wendy; Rechtman, Lindsay; Bae, Eunchan; Shinohara, Russell; King, Rachel; Laurson-Doube, Joanna; Helme, Anne (Lippincott Williams & Wilkins, 2023-06-15)

Background and objectives: Recent data suggest increasing global prevalence of multiple sclerosis (MS). Early diagnosis of MS reduces the burden of disability-adjusted life years and associated health care costs. Yet ...
Latin American consensus recommendations on the risk of infections in people with multiple sclerosis treated with disease modifying drugs

Silva, Berenice Anabel; Carnero Contentti, Edgar; Becker, Jefferson; Carranza, José I.; Correa Díaz, Edgar Patricio; Galleguillos Goiry, Lorna; Garcea, Orlando; Gracia, Fernando; Hamuy, Fernando; Macías, Miguel Angel; Navas, Carlos; Nuñez, Sebastián; Rojas, Juan Ignacio; Farez, Mauricio Franco; Alonso, Ricardo; López, Pablo Adrián (Elsevier, 2023-06-20)

Introduction: The emergence of several therapeutic options in multiple sclerosis (MS), which significantly modify the immune system functioning, has led to the need for the consideration of additional factors, such as risk ...
Serological response to SARS-CoV-2 vaccines in patients with multiple sclerosis in Argentina

Rojas, Juan Ignacio; Alonso, Ricardo; Cabrera, Mariela; Carnero Contentti, Edgar; Cristiano, Edgardo; Deri, Norma; Hryb, Javier Pablo; López, Pablo Adrián; Luetic, Geraldine G.; Patrucco, Liliana; Tkachuk, Verónica A.; Ysrraelit, María Célica; Zanga, Gisela; Cruces, Leonel; Turk, Gabriela; Longueira, Yesica; Laufer, Natalia; Nuñez, Sebastián (Fundación Revista Medicina, 2023-03-02)

Introduction: The objective was to assess the immunogenicity and effectiveness of vaccines against SARSCoV-2 in multiple sclerosis (MS) patients included in the Argentinean MS registry. Methods: A prospective cohort ...
Clinically relevant increases in serum neurofilament light chain and glial fibrillary acidic protein in patients with Susac syndrome

Plantone, Domenico; Sabatelli, Eleonora; Locci, Sara; Marrodán, Mariano; Laakso, Sini M.; Mateen, Farrah J.; Feresiadou, Amalia; Buelens, Tom; Bianco, Assunta; Fiol, Marcela Paula; Correale, Jorge; Tienari, Pentti; Calabresi, Paolo; De Stefano, Nicola; Iorio, Raffaele (Wiley, 2023-06-19)

Background and purpose: Serum levels of neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising neuro-axonal damage and astrocytic activation biomarkers. Susac syndrome (SS) is an ...
Clinical characteristics, course and prognosis of Multiple Sclerosis patients with epilepsy. A case control study: MS and epilepsy

Sánchez, M.; Marone, Abril; Silva, Walter H.; Marrodán, Mariano; Correale, Jorge (Elsevier, 2024-01-02)

Background and purpose: Although more common than in the general population, seizures are an atypical manifestation of multiple sclerosis (MS) and their pathophysiology is not well understood. This study aims to examine ...
Clinical impact of gender and age at onset on disease trajectory in primary progressive multiple sclerosis patients

Camerlingo, Sebastián; Rubinstein, Fernando; Ysrraelit, María Célica; Correale, Jorge; Carnero Contentti, Edgar; Rojas, Juan Ignacio; Patrucco, Liliana; Del Valle Leguizamon, Felisa; Tkachuk, Verónica A.; Fernández Liguori, Nora; Cristiano, Edgardo; Mainella, Carolina; Zanga, Gisela; Carrá, Adriana; Marrodán, Mariano; Martínez, Alejandra Diana; Silva, Berenice Anabel; Alonso, Ricardo (Sage Publications, 2024-01-21)

Background and objectives: Primary-progressive multiple sclerosis (PPMS) is characterized by gradual neurological deterioration without relapses. This study aimed to investigate the clinical impact of gender and age at ...
European Committee for Treatment and Research in Multiple Sclerosis and European Academy of Neurology consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

Otero-Romero, Susana; Lebrun-Frenay, Christine; Reyes, Saúl; Amato, María Pía; Campins, Magda; Farez, Mauricio Franco; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar (Wiley, 2023-06-09)

Background and purpose With the new highly active drugs available for people with multiple sclerosis (pwMS), vaccination becomes an essential part of the risk management strategy. We aimed to develop a European evidence-based ...
ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

Otero-Romero, Susana; Lebrun-Frenay, Christine; Reyes, Saúl; Amato, María Pía; Campins, Magda; Farez, Mauricio Franco; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar (Sage, 2023-06-09)

Background: With the new highly active drugs available for people with multiple sclerosis (pwMS), vaccination becomes an essential part of the risk management strategy. Objective: To develop a European evidence-based ...
2-Chlorodeoxyadenosine (Cladribine) preferentially inhibits the biological activity of microglial cells

Aybar, Florencia; Pérez, María Julia; Marcora, María Silvina; Samman, María Eugenia; Marrodán, Mariano; Pasquini, Juana María; Correale, Jorge (Elsevier Science, 2022-01-29)

Cladribine (2CdA) is a synthetic chlorinated purine nucleoside analogue which acts as a pro-drug requiring intracellular phosphorylation to be activated. It is biologically active in selected cell types, which results in ...
The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021

Tur, Carmen; Dubessy, Anne-Laure; Otero-Romero, Susana; Amato, María Pía; Derfuss, Tobías; Di Pauli, Franziska; Iacobaeus, Ellen; Mycko, Marcin; Abboud, Hesham; Achiron, Anat; Bellinvia, Angelo; Boyko, Alexey; Casanova, Jean-Laurent; Clifford, David; Dobson, Ruth; Farez, Mauricio Franco; Filippi, Massimo; Fitzgerald, Kathryn C.; Fonderico, Mattia; Gouider, Riadh (Stockton Press, 2022-02-23)

Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease-modifying treatments (DMTs) are now available. ...
From the prodromal stage of multiple sclerosis to disease prevention

Marrie, Ruth Ann; Allegretta, Mark; Barcellos, Lisa F.; Bebo, Bruce; Calabresi, Peter A.; Correale, Jorge; Davis, Benjamin; De Jager, Philip L.; Gasperi, Christiane; Greenbaum, Carla; Helme, Anne; Hemmer, Bernhard; Kanellis, Pamela; Kostich, Walter; Landsman, Douglas; Lebrun-Frenay, Christine; Makhani, Naila; Munger, Kassandra L.; Okuda, Darin T.; Ontaneda, Daniel (Nature Pub. Group, 2022-07-15)

A prodrome is an early set of signs or symptoms that indicate the onset of a disease before more typical symptoms develop. Prodromal stages are well recognized in some neurological and immune-mediated diseases such as ...
Guía de práctica clínica: tratamiento agudo de las enfermedades inflamatorio-desmielinizantes del sistema nervioso central: esclerosis múltiple, espectro de la neuromielitis óptica, encefalomielitis diseminada aguda, enfermedades asociadas a anticuerpos antiglicoproteína de la membrana del oligodendrocito, mielitis aguda y neuritis óptica. Elaborada por el Grupo de Trabajo de Enfermedades Desmielinizantes. Sociedad Neurológica Argentina

Hryb, Javier Pablo; Tavolini, Darío; Pagani Cassará, Fátima; Silva, Berenice Anabel; Rojas, Juan Ignacio; Sinay, Vladimiro; Tkachuk, Verónica A.; Alonso, Ricardo; Carnero Contentti, Edgar; Ysrraelit, María Célica; Cohen, Leila; Rotta Escalante, Roberto; Mainella, Carolina; Diana Martínez, Alejandra; Liwacki, Susana; Luetic, Geraldine G.; Bestoso, Santiago; Vázquez, Guido; Piedrabuena, Raúl; Vrech, Carlos (Elsevier, 2023-06-12)

Introducción El tratamiento adecuado y a tiempo de las manifestaciones agudas de las enfermedades inflamatorias-desmielinizantes del sistema nervioso central incluyendo a la encefalomielitis diseminada aguda, los síndromes ...

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