Enfermedades Desmielinizantes.artículos: Envíos recientes

  • Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model 
    Wies Mancini, Victoria Sofía Berenice; Di Pietro, Anabella A.; de Olmos, Soledad; Silva Pinto, Pablo; Vence, Marianela; Marder, Mariel; Igaz, Lionel M.; Marcora, María Silvina; Pasquini, Juana María; Correale, Jorge; Pasquini, Laura Andrea (Oxford, 2022-03)
    Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive ...
  • Childhood focal compressive mononeuropathies during the COVID-19 pandemic in Buenos Aires, Argentina 
    Brand, Patricio; Cejas, Claudia Patricia; Rivero, Alberto Daniel (John Wiley & Sons, 2022-05)
    Introduction/aims: Focal peripheral neuropathies are infrequently seen in pediatric patients. The COVID-19 pandemic has disrupted normal life for many people, including complete lockdowns and school closing for long periods ...
  • Association between infections, the microbiome, vaccination, and neuromyelitis optica spectrum disorder 
    Carnero Contentti, Edgar; Correale, Jorge (Sage, 2022-07-28)
    Neuromyelitis optica spectrum disorder (NMOSD) is a devastating antibody-mediated condition of the central nervous system. As in other autoimmune diseases, there is considerable evidence to suggest that NMOSD arises from ...
  • Current Perspectives: Evidence to Date on BTK Inhibitors in the Management of Multiple Sclerosis 
    Carnero Contentti, Edgar; Correale, Jorge (Dove Press Limited, 2022-10-06)
    Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system leading to demyelination and neurodegeneration. Basic and translational studies have shown that B cells and myeloid cells are critical ...
  • Evaluation of the times of disability progression and related factors in patients with primary progressive multiple sclerosis from Argentina 
    Alonso, Ricardo; Garcea, Orlando; Rojas, Juan Ignacio; Alonso Serena, Marina; Lázaro, Luciana; López, Pablo Adrián; Casas, Magdalena; Tkachuk, Verónica A.; Steinberg, Judith; Barboza, Andrés G.; Martínez, Alejandra Diana; Ysrraelit, María Célica; Correale, Jorge; Marrodán, Mariano; Chertcoff, Aníbal; Deri, Norma; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Pestchanker, Claudia (Elsevier, 2022-01-02)
    Background PPMS (primary progressive multiple sclerosis) patients represent less than 10% of MS patients in Argentina, men and women were similarly affected and most of them had a severe functional impairment. More rapid ...
  • The role of the gut microbiota in multiple sclerosis 
    Correale, Jorge; Hohlfeld, Reinhard; Baranzini, Sergio E. (Nature Pub. Group, 2022-09)
    During the past decade, research has revealed that the vast community of micro-organisms that inhabit the gut - known as the gut microbiota - is intricately linked to human health and disease, partly as a result of its ...
  • Rebound activity after fingolimod cessation: A case - control study 
    Barboza, Andrés G.; Gaitán, María Inés; Alonso, Ricardo; Ysrraelit, María Célica; Luetic, Geraldine G.; Liwacki, Susana; Patrucco, Liliana; Halfon, Mario Javier; Burgos, Marcos; Mainella, Carolina; Piedrabuena, Raúl; Recchia, Luciano; Steinberg, Judith; Tkachuk, Verónica A.; Zanga, Gisela; Carra, Adriana; Chertcoff, Aníbal; Fernández Liguori, Nora; Lázaro, Luciana; Menichini, María Laura (Elsevier, 2022-02-09)
    Background: There has been an increase in the number of reports of multiple sclerosis (MS) rebound activity (RA), which is usually defined as a severe disease reactivation after natalizumab or fingolimod withdrawal that ...
  • Impact of Andropause on Multiple Sclerosis 
    Ysrraelit, María Célica; Correale, Jorge (Frontiers Research Foundation, 2021-11-05)
    Andropause results from the natural decrease in testosterone levels that occurs with age. In contrast to menopause, which is a universal, well-characterized process associated with absolute gonadal failure, andropause ...
  • Confirming a Historical Diagnosis of Multiple Sclerosis: Challenges and Recommendations 
    Solomon, Andrew J.; Arrambide, Georgina; Brownlee, Wallace J.; Cross, Anne H.; Gaitán, María Inés; Lublin, Fred D.; Makhani, Naila; Mowry, Ellen M.; Reich, Daniel S.; Rovira, Álex; Weinshenker, Brian G.; Cohen, Jeffrey A. (Lippincott Williams & Wilkins, 2022-06)
    Patients with a historical diagnosis of multiple sclerosis (MS)-a patient presenting with a diagnosis of MS made previously and by a different clinician-present specific diagnostic and therapeutic challenges in clinical ...
  • Computational basis of decision-making impairment in multiple sclerosis 
    Fernández, Rodrigo Sebastián; Crivelli, Lucía; Pedreira, María Eugenia; Allegri, Ricardo Francisco; Correale, Jorge (Sage, 2021-12-21)
    Background: Multiple sclerosis (MS) is commonly associated with decision-making, neurocognitive impairments, and mood and motivational symptoms. However, their relationship may be obscured by traditional scoring ...
  • Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: Evaluation of 794 attacks from a nationwide registry in Argentina 
    Carnero Contentti, Edgar; López, Pablo Adrián; Pettinicchi, Juan Pablo; Criniti, Juan; Pappolla, Agustín; Miguez, Jimena; Patrucco, Liliana; Cristiano, Edgardo; Liwacki, Susana; Tkachuk, Verónica A.; Balbuena Aguirre, María Eugenia; Vrech, Carlos; Deri, Norma; Correale, Jorge; Marrodán, Mariano; Ysrraelit, María Célica; Leguizamon, Felisa; Luetic, Geraldine G.; Menichini, María Laura; Tavolini, Darío (Elsevier, 2021-12-13)
    Background: Identification of triggers that potentially instigate attacks in neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) has remained challenging. We aimed to analyze the seasonality of NMOSD ...
  • Clinical and demographic characteristics of male MS patients included in the national registry-RelevarEM. Does sex or phenotype make the difference in the association with poor prognosis? 
    Luetic, Geraldine G.; Menichini, María Laura; Vrech, Carlos; Pappolla, Agustín; Patrucco, Liliana; Cristiano, Edgardo; Marrodán, Mariano; Ysrraelit, María Célica; Fiol, Marcela Paula; Correale, Jorge; Cohen, Leila; Alonso, Ricardo; Silva, Berenice Anabel; Casas, Magdalena; Garcea, Orlando; Deri, Norma; Burgos, Marcos; Liwacki, Susana; Tkachuk, Verónica A.; Barboza, Andrés G. (Elsevier, 2021-11-17)
    Background In multiple sclerosis demographics there is a well-known female prevalence and male patients have been less specifically evaluated in clinical studies, though some clinical differences have been reported between ...
  • Guía de práctica clínica: tratamiento sintomático de esclerosis múltiple. Grupo de Trabajo de Enfermedades Desmielinizantes. Sociedad Neurológica Argentina 
    Barboza, Andrés G.; Sinay, Vladimiro; Zanga, Gisela; Alonso, Ricardo; Silva, Berenice Anabel; Saladino, María Laura; Cohen, Leila; Luetic, Geraldine G.; Camerlingo, S.; Ysrraelit, María Célica; Tenembaum, S. N.; Tarulla, Adriana; Carnero Contentti, Edgar; López, Pablo Adrián; Pita, Cecilia; Tavolini, Darío; Steinberg, Judith; Menichini, María Laura; Rojas, Juan Ignacio; Tizio, Santiago (Elsevier, 2022-06-18)
    Introducción El tratamiento sintomático en la esclerosis múltiple (EM) representa uno de los pilares del abordaje global de esta patología. El tratamiento específico de los síntomas tiene como objetivo reducir o eliminar ...
  • The Immune Response in Multiple Sclerosis 
    Rodríguez Murúa, Sofía; Farez, Mauricio Franco; Quintana, Francisco J. (Annual Reviews, 2021-10-04)
    Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of ...
  • Acting centrally or peripherally: A renewed interest in the central nervous system penetration of disease-modifying drugs in multiple sclerosis 
    Correale, Jorge; Halfon, Mario Javier; Jack, Dominic; Rubstein, Adrián; Villa, Andrés (Elsevier, 2021-09-14)
    With the recent approval of cladribine tablets, siponimod and ozanimod, there has been a renewed interest into the extent to which these current generation disease-modifying therapies (DMTs) are able to cross into the ...
  • Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies 
    Carnero Contentti, Edgar; Correale, Jorge (BioMed Central, 2021-09-16)
    Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) characterized by acute optic neuritis (ON) and transverse myelitis (TM). NMO is caused by a pathogenic serum IgG ...
  • Interleukin-35 is a critical regulator of immunity during helminth infections associated with multiple sclerosis 
    Correale, Jorge; Marrodán, Mariano; Carnero Contentti, Edgar (Wiley, 2021-07-01)
    Multiple sclerosis (MS) is currently thought to arise by interactions between genetic susceptibility and environmental factors. Infections in general trigger autoimmune responses causing clinical manifestations of disease. ...
  • Research priorities in multiple sclerosis in Latin America: A multi-stakeholder call to action to improve patients care: Research priorities in MS in LATAM 
    Rojas, Juan Ignacio; Carnero Contentti, Edgar; Abad, Patricio; Aguayo, Adriana; Alonso, Ricardo; Bauer, Johana; Becker, Jefferson; Bustos, Andrea K.; Carcamo, Claudia A.; Carrá, Adriana; Correa Díaz, Edgar Patricio; Correale, Jorge; Cristiano, Edgardo; Diaz, Alejandro J.; Fernandez Liguori, Nora; Flores, José; Fruns, Manuel; Garcea, Orlando; Ysrraelit, María Célica; LACTRIMS working group (Elsevier, 2021-05-24)
    As human and economic resources are limited, especially in Latin America (LATAM), it is important to identify research priorities to improve multiple sclerosis (MS) patients care in the region. The objective was to generate ...
  • Multiple sclerosis care units in Latin America: Consensus recommendations about its objectives and functioning implementation 
    Cristiano, Edgardo; Abad, Patricio; Becker, Jefferson; Carrá, Adriana; Correale, Jorge; Flores, José; Fruns, Manuel; Garcea, Orlando; Garcia Bónitto, Juan; Gracia, Fernando; Hamuy, Fernando; Navas, Carlos; Patrucco, Liliana; Rivera, Víctor M.; Velazquez, Merced; Rojas, Juan Ignacio (Elsevier, 2021-10-15)
    Objective Currently, there are several reasons to promote worldwide the concept of multiple sclerosis care units (MSCU) for a better management of affected patients. Ideally, the MSCU should have some human and technical ...
  • Guías de práctica para indicación y contraindicaciones de vacunación de pacientes con esclerosis múltiple 
    Barboza, Andrés G.; Sinay, Vladimiro; Silva, Berenice Anabel; Rojas, Juan Ignacio; Ysrraelit, María Célica; Carnero Contentti, Edgar; Negrotto, Laura; Tavolini, Darío; Deri, Norma; Tizio, Santiago; Gaitán, María Inés; Luetic, Geraldine G.; Patrucco, Liliana; Martínez, Alejandra Diana; Parada Marcilla, Marcela; Hryb, Javier Pablo; Alonso, Ricardo; Bestoso, Santiago; Cabrera, Lorena M.; Cristiano, Edgardo (Elsevier, 2021-03)
    Introducción La esclerosis múltiple es una enfermedad con componente autoinmune, y un número significativo de pacientes se encuentra bajo tratamiento inmunomodulador e inmunosupresor. Frecuentemente los médicos tratantes ...

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