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Spinal Cord Involvement in MS and Other Demyelinating Diseases

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dc.contributor.author Marrodán, Mariano
dc.contributor.author Gaitán, María Inés
dc.contributor.author Correale, Jorge
dc.date.accessioned 2020-12-29T12:50:21Z
dc.date.available 2020-12-29T12:50:21Z
dc.date.issued 2020-05-22
dc.identifier.citation Marrodan, M., Gaitán, M.I., Correale, J., 2020. Spinal Cord Involvement in MS and Other Demyelinating Diseases. Biomedicines 8. https://doi.org/10.3390/biomedicines8050130 en_US
dc.identifier.uri https://doi.org/10.3390/biomedicines8050130
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/288
dc.description.abstract Diagnostic accuracy is poor in demyelinating myelopathies, and therefore a challenge for neurologists in daily practice, mainly because of the multiple underlying pathophysiologic mechanisms involved in each subtype. A systematic diagnostic approach combining data from the clinical setting and presentation with magnetic resonance imaging (MRI) lesion patterns, cerebrospinal fluid (CSF) findings, and autoantibody markers can help to better distinguish between subtypes. In this review, we describe spinal cord involvement, and summarize clinical findings, MRI and diagnostic characteristics, as well as treatment options and prognostic implications in different demyelinating disorders including: multiple sclerosis (MS), neuromyelitis optica spectrum disorder, acute disseminated encephalomyelitis, anti-myelin oligodendrocyte glycoprotein antibody-associated disease, and glial fibrillary acidic protein IgG-associated disease. Thorough understanding of individual case etiology is crucial, not only to provide valuable prognostic information on whether the disorder is likely to relapse, but also to make therapeutic decision-making easier and reduce treatment failures which may lead to new relapses and long-term disability. Identifying patients with monophasic disease who may only require acute management, symptomatic treatment, and subsequent rehabilitation, rather than immunosuppression, is also important. en_US
dc.language.iso eng en_US
dc.publisher MDPI en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.subject Neuromyelitis Optica en_US
dc.subject Neuromielitis Óptica en_US
dc.subject Spinal Cord en_US
dc.subject Médula Espinal en_US
dc.subject Demyelinating Diseases en_US
dc.subject Enfermedades Desmielinizantes en_US
dc.title Spinal Cord Involvement in MS and Other Demyelinating Diseases en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.relation.ispartofVOLUME 8
dc.relation.ispartofNUMBER 5
dc.relation.ispartofPAGINATION 130
dc.relation.ispartofCOUNTRY Suiza
dc.relation.ispartofCITY Basel
dc.relation.ispartofISSN 2227-9059
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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