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dc.contributor.author | Castiglione, Juan Ignacio | |
dc.contributor.author | Marrodán, Mariano | |
dc.contributor.author | Alessandro, Lucas | |
dc.contributor.author | Taratuto, Ana Lía | |
dc.contributor.author | Brand, Patricio | |
dc.contributor.author | Nogués, Martín | |
dc.contributor.author | Barroso, Fabio Adrián | |
dc.date.accessioned | 2021-01-12T14:02:52Z | |
dc.date.available | 2021-01-12T14:02:52Z | |
dc.date.issued | 2021-01-01 | |
dc.identifier.citation | Castiglione JI, Marrodan M, Alessandro L, Taratuto AL, Brand P, Nogués M, Barroso F. Vasculitic Peripheral Neuropathy, Differences Between Systemic and Non-Systemic Etiologies: A Case Series and Biopsy Report. J Neuromuscul Dis. 2021;8(1):155-161. doi: 10.3233/JND-200576 | en_US |
dc.identifier.uri | https://doi.org/10.3233/JND-200576 | |
dc.identifier.uri | https://repositorio.fleni.org.ar/handle/123456789/307 | |
dc.description.abstract | Background:Vasculitic peripheral neuropathy (VPN) is caused by vessel inflammation leading to peripheral nerve injury of acute-to-subacute onset. When VPN occurs in the context of systemic disease it is classified as Systemic Vasculitic Neuropathy (SVN) and as Non-Systemic Vasculitic Neuropathy (NSVN) when restricted to the nerves. Objective:This study aimed to compare the clinical characteristics, biopsy findings and disease outcome in patients with VPN. Methods:Clinical records of adult patients with VPN diagnosed at our institution between June-2002 and June-2019 were retrospectively reviewed. Demographic characteristics, clinical manifestations, nerve conduction studies, nerve biopsies, treatment and clinical evolution were analyzed in all patients with at least 6 months follow-up. Results:Twenty-five patients with VPN were included (SVN, n = 10; NSVN, n = 15). No significant differences in demographic or clinical features were found between groups. The median delay between symptom onset and nerve biopsy was significantly longer in NSVN patients (10 vs 5.5 months, p = 0.009). Erythrocyte sedimentation rate (ESR) values over 20 mm/h were significantly more common in SVN patients (100% vs. 60%, p = 0.024). Nerve biopsies showed active lesions more frequently in treatment-naive patients compared to those who had received at least 2 weeks of corticosteroids (92% vs 38%; p = 0.03), with a higher proportion of definite VPN cases (92 vs 46%; p = 0.04). Conclusions:Although the clinical manifestations are similar, ESR is an important tool to help distinguish between both conditions. Early nerve biopsy in untreated patients increases diagnostic accuracy, avoiding misdiagnosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | IOS | en_US |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.subject | Peripheral Nervous System Diseases | en_US |
dc.subject | Enfermedades del Sistema Nervioso Periférico | en_US |
dc.subject | Peripheral Neuropathy | en_US |
dc.subject | Neuropatía Periférica | en_US |
dc.title | Vasculitic Peripheral Neuropathy, Differences Between Systemic and Non-Systemic Etiologies: A Case Series and Biopsy Report | en_US |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.type | info:eu-repo/semantics/article | en_US |
dc.description.fil | Fil: Castiglione, Juan Ignacio. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina. | |
dc.description.fil | Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Taratuto, Ana Lía. Fleni. Departamento de Neuropatología y Biología Molecular. Centro de Referencia Neuropatológico de Encefalopatías Espongiformes Transmisibles; Argentina. | |
dc.description.fil | Fil: Brand, Patricio. Fleni. Departamento de Neurología. Servicio de Neurofisiología; Argentina. | |
dc.description.fil | Fil: Nogués, Martín. Fleni. Departamento de Neurología; Argentina. | |
dc.description.fil | Fil: Barroso, Fabio Adrián. Fleni. Departamento de Neurología. Sección de Enfermedades Neuromusculares; Argentina. | |
dc.relation.ispartofVOLUME | 8 | |
dc.relation.ispartofNUMBER | 1 | |
dc.relation.ispartofPAGINATION | 155-161 | |
dc.relation.ispartofCOUNTRY | Países Bajos | |
dc.relation.ispartofCITY | Amsterdam | |
dc.relation.ispartofTITLE | Journal of neuromuscular diseases | |
dc.relation.ispartofISSN | 2214-3602 | |
dc.type.snrd | info:ar-repo/semantics/artículo | es_ES |