DSpace Repository

What percentage of AQP4-ab-negative NMOSD patients are MOG-ab positive? A study from the Argentinean multiple sclerosis registry (RelevarEM)

Show simple item record

dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author López, Pablo Adrián
dc.contributor.author Pettinicchi, Juan Pablo
dc.contributor.author Pappolla, Agustín
dc.contributor.author Miguez, Jimena
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Vrech, Carlos
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Liwacki, Susana
dc.contributor.author Correale, Jorge
dc.contributor.author Marrodán, Mariano
dc.contributor.author Gaitán, María Inés
dc.contributor.author Fiol, Marcela Paula
dc.contributor.author Negrotto, Laura
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Burgos, Marcos
dc.contributor.author Leguizamon, Felisa
dc.contributor.author Tavolini, Darío
dc.contributor.author Deri, Norma
dc.date.accessioned 2021-01-19T12:26:09Z
dc.date.available 2021-01-19T12:26:09Z
dc.date.issued 2021-01-07
dc.identifier.citation Carnero Contentti E, Lopez PA, Pettinicchi JP, Pappolla A, Miguez J, Patrucco L, Cristiano E, Vrech C, Tkachuk V, Liwacki S, Correale J, Marrodan M, Gaitán MI, Fiol M, Negrotto L, Ysrraelit MC, Burgos M, Leguizamon F, Tavolini D, Deri N, Balbuena ME, Mainella C, Luetic G, Blaya P, Hryb J, Menichini ML, Alvez Pinheiro A, Nofal P, Zanga G, Barboza A, Martos I, Lazaro L, Alonso R, Silva E, Bestoso S, Fracaro ME, Carrá A, Garcea O, Fernandez Liguori N, Alonso Serena M, Caride A, Rojas JI. What percentage of AQP4-ab-negative NMOSD patients are MOG-ab positive? A study from the Argentinean multiple sclerosis registry (RelevarEM). Mult Scler Relat Disord. 2021 Jan 7;49:102742. doi: 10.1016/j.msard.2021.102742. en_US
dc.identifier.uri https://doi.org/10.1016/j.msard.2021.102742
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/316
dc.description.abstract Background Myelin oligodendrocyte glycoprotein antibodies (MOG-ab) have been described in aquaporin-4-antibodies(AQP4-ab)-negative neuromyelitis optica spectrum disorder (NMOSD) patients. We aimed to evaluate the percentage of AQP4-ab-negative NMOSD patients who are positive for MOG-ab in a cohort of Argentinean patients included in RelevarEM (Clinical Trials registry number NCT03375177). Methods RelevarEM is a longitudinal, strictly observational multiple sclerosis (MS) and NMOSD registry in Argentina. Of 3031 consecutive patients (until March 2020), 165 patients with phenotype of suspected NMOSD, whose relevant data for the purpose of this study were available, were included. Data on demographic, clinical, paraclinical and treatment in AQP4-ab (positive, negative and unknown) and MOG-ab (positive and negative) patients were evaluated. Results A total of 165 patients (79 AQP4-Ab positive, 67 AQP4-Ab negative and 19 unknown) were included. Of these, 155 patients fulfilled the 2015 NMOSD diagnostic criteria. Of 67 AQP4-Ab-negative patients, 36 (53.7%) were tested for MOG-Ab and 10 of them (27.7%) tested positive. Serum AQP4-ab levels were tested by means of cell-based assay (CBA) in 48 (35.2%), based on tissue-based indirect immunofluorescence assays in 58 (42.6%) and enzyme-linked immunosorbent assay in 4 (2.9%). All MOG-ab were tested by CBA. Optic neuritis (90%) was the most frequent symptom at presentation and optic nerve lesions the most frequent finding (80%) in neuroimaging of MOG-ab-associated disease. Of these, six (60%) patients were under immunosuppressant treatments at latest follow-up. Conclusion We observed that 27.7% (10/36) of the AQP4-ab-negative patients tested for MOG-ab were positive for this antibody, in line with results from other world regions. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Neuromyelitis Optica en_US
dc.subject Neuromielitis Óptica en_US
dc.subject Myelin-Oligodendrocyte Glycoprotein en_US
dc.subject Glicoproteína Mielina-Oligodendrócito en_US
dc.subject Aquaporin 4 en_US
dc.subject Acuaporina 4 en_US
dc.subject Latin America en_US
dc.subject América Latina en_US
dc.title What percentage of AQP4-ab-negative NMOSD patients are MOG-ab positive? A study from the Argentinean multiple sclerosis registry (RelevarEM) en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Carnero Contentti, Edgar. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: López, Pablo Adrián. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Pettinicchi, Juan Pablo. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Miguez, Jimena. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Vrech, Carlos. Sanatorio Allende. Departamento de Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín. Servicio de Neurología. Sección de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Liwacki, Susana. Clínica Universitaria Reina Fabiola. Servicio de Neurología; Argentina.
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina
dc.description.fil Fil: Marrodán, Mariano. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Gaitán, María Inés. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Fiol, Marcela Paula. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Negrotto, Laura. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Burgos, Marcos. Hospital San Bernardo. Servicio de Neurología; Argentina.
dc.description.fil Fil: Leguizamon, Felisa. Hospital de Agudos Dr. Teodoro Álvarez; Argentina.
dc.description.fil Fil: Tavolini, Darío. INECO; Argentina.
dc.description.fil Fil: Deri, Norma. Centro de Investigaciones Diabaid; Argentina.
dc.relation.ispartofVOLUME 49
dc.relation.ispartofNUMBER 102742
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Amsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


Files in this item

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess

Search DSpace


Browse

My Account

Statistics