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Radiologically isolated syndrome: from biological bases to practical management

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dc.contributor.author Barboza, Andrés G.
dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author Curbelo, María Celeste
dc.contributor.author Halfon, Mario Javier
dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Silva, Berenice Anabel
dc.contributor.author Sinay, Vladimiro
dc.contributor.author Tizio, Santiago
dc.contributor.author Ysrraelit, María Célica
dc.contributor.author Alonso, Ricardo
dc.date.accessioned 2021-01-27T14:07:52Z
dc.date.available 2021-01-27T14:07:52Z
dc.date.issued 2021-01-25
dc.identifier.citation Barboza AG, Carnero Contentti E, Curbelo MC, Halfon MJ, Rojas JI, Silva BA, Sinay V, Tizio S, Ysrraelit MC, Alonso R. Radiologically isolated syndrome: from biological bases to practical management. Neurol Sci. 2021 Jan 25. doi: 10.1007/s10072-021-05069-6. en_US
dc.identifier.uri https://doi.org/10.1007/s10072-021-05069-6
dc.identifier.uri https://repositorio.fleni.org.ar/handle/123456789/345
dc.description.abstract Background: Technological advances and greater availability of magnetic resonance imaging have prompted an increment on incidental and unexpected findings within the central nervous system. The concept of radiologically isolated syndrome characterizes a group of subjects with images suggestive of demyelinating disease in the absence of a clinical episode compatible with multiple sclerosis. Since the description of this entity, many questions have arisen; some have received responses but others remain unanswered. A panel of experts met with the objective of performing a critical review of the currently available evidence. Definition, prevalence, biological bases, published evidence, and implications on patient management were reviewed. Thirty to 50% of subjects with radiologically isolated syndrome will progress to multiple sclerosis in 5 years. Male sex, age < 37 years old, and spinal lesions increase the risk. These subjects should be evaluated by a multiple sclerosis specialist, carefully excluding alternative diagnosis. An initial evaluation should include a brain and complete spine magnetic resonance, visual evoked potentials, and identification of oligoclonal bands in cerebrospinal fluid. Disease-modifying therapies could be considered when oligoclonal bands or radiological progression is present. Conclusion: At present time, radiologically isolated syndrome cannot be considered a part of the multiple sclerosis spectrum. However, a proportion of patients may evolve to multiple sclerosis, meaning it represents much more than just a radiological finding. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Magnetic Resonance Imaging en_US
dc.subject Imagen por Resonancia Magnética en_US
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.subject Oligoclonal Bands en_US
dc.subject Bandas Oligoclonales en_US
dc.subject Radiologically Isolated Syndrome en_US
dc.subject Síndrome Radiológico Aislado en_US
dc.title Radiologically isolated syndrome: from biological bases to practical management en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Barboza, Andrés G. Hospital Central de Mendoza. Servicio de Neurología; Argentina.
dc.description.fil Fil: Carnero Contentti, Edgar. Hospital Alemán. Departamento de Neurociencias. Unidad de Neuroinmunología; Argentina.
dc.description.fil Fil: Curbelo, María Celeste. Hospital Británico. Sección de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Halfon, Mario Javier. Hospital Británico. Sección de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Rojas, Juan Ignacio. Hospital Italiano. Centro de Esclerosis Múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Silva, Berenice Anabel. Hospital Ramos Mejía. Clínica de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Sinay, Vladimiro. Fundación Favaloro; Argentina.
dc.description.fil Fil: Tizio, Santiago. Hospital Español de La Plata; Argentina.
dc.description.fil Fil: Ysrraelit, María Célica. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Alonso, Ricardo. Hospital Ramos Mejía. Clínica de Esclerosis Múltiple; Argentina.
dc.relation.ispartofCOUNTRY Italia
dc.relation.ispartofCITY Milán
dc.relation.ispartofTITLE Neurological sciences
dc.relation.ispartofISSN 1590-3478
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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