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Usage trend of oral drugs for multiple sclerosis patients in Argentina

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dc.contributor.author Alonso, Ricardo
dc.contributor.author Garcea, Orlando
dc.contributor.author Eizaguirre, María Barbara
dc.contributor.author Man, Federico
dc.contributor.author Lopez Bizzo, Abril
dc.contributor.author Cohen, Leila
dc.contributor.author Rojas, Juan Ignacio
dc.contributor.author Patrucco, Liliana
dc.contributor.author Cristiano, Edgardo
dc.contributor.author Pita, Cecilia
dc.contributor.author Tkachuk, Verónica A.
dc.contributor.author Balbuena Aguirre, María Eugenia
dc.contributor.author Carnero Contentti, Edgar
dc.contributor.author López, Pablo Adrián
dc.contributor.author Pettinicchi, Juan Pablo
dc.contributor.author Deri, Norma
dc.contributor.author Miguez, Jimena
dc.contributor.author Pappolla, Agustín
dc.contributor.author Lázaro, Luciana
dc.contributor.author Fernández Liguori, Nora
dc.contributor.author Correale, Jorge
dc.contributor.author Carrá, Adriana
dc.contributor.author Silva, Berenice Anabel
dc.date.accessioned 2021-03-03T13:51:34Z
dc.date.available 2021-03-03T13:51:34Z
dc.date.issued 2020-12-02
dc.identifier.citation Alonso R, Garcea O, Eizaguirre MB, Man F, Bizzo AL, Cohen L, Rojas JI, Patrucco L, Cristiano E, Pita C, Tkachuk V, Balbuena ME, Carnero Contentti E, López PA, Pettinicchi JP, Deri N, Miguez J, Pappolla A, Lázaro L, Liguori NF, Correale J, Carrá A, Silva BA. Usage trend of oral drugs for multiple sclerosis patients in Argentina. Mult Scler Relat Disord. 2020 Dec 2;47:102664. doi: 10.1016/j.msard.2020.102664. Epub ahead of print. en_US
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/373
dc.identifier.uri https://doi.org/10.1016/j.msard.2020.102664
dc.description.abstract Introduction: Over the past decade, numerous disease modifying drugs (DMDs) for relapsing- remitting multiple sclerosis (RRMS) have been approved in Argentina. The use of oral DMDs (oDMDs) has increased in recent years, although real-life data in our region is limited. We aimed to describe the tendency in the use of oDMDs (as first treatment option or after switch) in relationship with their approval in Argentina. Methods: A retrospective study in a cohort of MS patients from five Argentinian MS centers was conducted. Regarding the availability of different oDMDs in Argentina, we define three periods (P1-3): P1: 2012 - 2014; P2: 2015 - 2017 and P3: 2018 - 2020. An analysis was performed comparing between these three periods to assess the tendency for oDMDs use over time. Result: The most frequently prescribed treatment as first DMD was: interferon beta 1a (40%) in P1, fingolimod (37.3%) in P2 and also fingolimod (35%) in P3. We found an increase in the use of oDMTs as initial treatment over time (P1: 17.7%, P2: 63.9% and P3: 65.0%; Chi-square = 41.9 p <0.01). We also found a tendency to increase the use of oDMTs after a first switch (P1: 45.5%, P2: 60.1% and P3 78.3%). Multivariate analysis showed that disease evolution (OR=1.06, p=0.04), and year of treatment initiation (OR=1.01 p<0.01) were independently associated with choice of oDMTs. Conclusion: This study identified an increasing tendency for the use of oDMDs as initial treatment of RMS in relationship with their approval in Argentina. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Multiple Sclerosis en_US
dc.subject Esclerosis Múltiple en_US
dc.subject Argentina en_US
dc.title Usage trend of oral drugs for multiple sclerosis patients in Argentina en_US
dc.type info:eu-repo/semantics/publishedVersion
dc.type info:eu-repo/semantics/article en_US
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Alonso, Ricardo. Hospital JM Ramos Mejía. Centro Universitario de Esclerosis Múltiple; Argentina. Sanatorio Güemes. Servicio de Neurología; Argentina.
dc.description.fil Fil: Garcea, Orlando. Hospital JM Ramos Mejía. Centro Universitario de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Eizaguirre, María Barbara. Hospital JM Ramos Mejía. Centro Universitario de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Man, Federico. Hospital Ramos Mejía. Servicio de Neurología; Argentina.
dc.description.fil Fil: López Bizzo, Abril. Hospital Ramos Mejía. Servicio de Neurología; Argentina.
dc.description.fil Fil: Cohen, Leila. Hospital JM Ramos Mejía. Centro Universitario de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Rojas, Juan Ignacio. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Patrucco, Liliana. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Cristiano, Edgardo. Centro de esclerosis múltiple de Buenos Aires; Argentina.
dc.description.fil Fil: Pita, Cecilia. Hospital JM Ramos Mejía. Centro Universitario de Esclerosis Múltiple; Argentina.
dc.description.fil Fil: Tkachuk, Verónica A. Hospital de Clínicas José de San Martín. Servicio de Neurología. Sección de Esclerosis Múltiple y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Balbuena Aguirre, María Eugenia. Hospital de Clínicas José de San Martín. Servicio de Neurología. Sección de Esclerosis Múltiple y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Carnero Contentti, Edgar. Hospital Alemán. Department of Neuroscience. Neuroimmunology Unit; Argentina.
dc.description.fil Fil: López, Pablo Adrián. Hospital Alemán. Department of Neuroscience. Neuroimmunology Unit; Argentina.
dc.description.fil Fil: Pettinicchi, Juan Pablo. Hospital Alemán. Department of Neuroscience. Neuroimmunology Unit; Argentina.
dc.description.fil Fil: Deri, Norma. Centro de Investigaciones Diabaid; Argentina.
dc.description.fil Fil: Miguez, Jimena. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Pappolla, Agustín. Hospital Italiano de Buenos Aires. Servicio de Neurología; Argentina.
dc.description.fil Fil: Lázaro, Luciana. Sanatorio Güemes. Servicio de Neurología; Argentina.
dc.relation.ispartofCOUNTRY Países Bajos
dc.relation.ispartofCITY Ámsterdam
dc.relation.ispartofTITLE Multiple sclerosis and related disorders
dc.relation.ispartofISSN 2211-0356
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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