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Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease

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dc.contributor.author Ewers, Michael
dc.contributor.author Luan, Ying
dc.contributor.author Frontzkowski, Lukas
dc.contributor.author Neitzel, Julia
dc.contributor.author Rubinski, Anna
dc.contributor.author Dichgans, Martin
dc.contributor.author Hassenstab, Jason
dc.contributor.author Gordon, Brian A.
dc.contributor.author Chhatwal, Jasmeer P.
dc.contributor.author Levin, Johannes
dc.contributor.author Schofield, Peter R.
dc.contributor.author Benzinger, Tammie L.S.
dc.contributor.author Morris, John C.
dc.contributor.author Goate, Alison M.
dc.contributor.author Karch, Celeste M.
dc.contributor.author Fagan, Anne M.
dc.contributor.author McDade, Eric
dc.contributor.author Allegri, Ricardo Francisco
dc.contributor.author Berman, Sarah B.
dc.contributor.author Chui, Helena C.
dc.date.accessioned 2021-03-30T14:50:48Z
dc.date.available 2021-03-30T14:50:48Z
dc.date.issued 2021-03-16
dc.identifier.citation Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, Fagan AM, McDade E, Allegri R, Berman S, Chui HC, Cruchaga C, Farlow M, Graff-Radford N, Jucker M, Lee JH, Martins RN, Mori H, Perrin R, Xiong C, Rossor M, Fox NC, O'Connor A, Salloway S, Danek A, Buerger K, Bateman RJ, Habeck C, Stern Y, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative and the Dominantly Inherited Alzheimer Network. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain. 2021 Aug 17;144(7):2176-2185. doi: 10.1093/brain/awab112 es_ES
dc.identifier.uri https://doi.org/10.1093/brain/awab112
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/394
dc.description.abstract Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal aging, we tested the hypothesis that higher segregation of the brain's connectome into distinct functional networks represents a functional mechanism underlying cognitive resilience in Alzheimer's disease. Using resting-state functional MRI, we assessed both resting-state-fMRI global system segregation, i.e. the balance of between-network to within-network connectivity, and the alternate index of modularity Q as predictors of cognitive resilience. We performed all analyses in two independent samples for validation: First, we included 108 individuals with autosomal dominantly inherited Alzheimer's disease and 71 non-carrier controls. Second, we included 156 amyloid-PET positive subjects across the spectrum of sporadic Alzheimer's disease as well as 184 amyloid-negative controls. In the autosomal dominant Alzheimer's disease sample, disease severity was assessed by estimated years from symptom onset. In the sporadic Alzheimer's sample, disease stage was assessed by temporal-lobe tau-PET (i.e. composite across Braak stage I & III regions). In both samples, we tested whether the effect of disease severity on cognition was attenuated at higher levels of functional network segregation. For autosomal dominant Alzheimer's disease, we found higher fMRI-assessed system segregation to be associated with an attenuated effect of estimated years from symptom onset on global cognition (p = 0.007). Similarly, for sporadic Alzheimer's disease patients, higher fMRI-assessed system segregation was associated with less decrement in global cognition (p = 0.001) and episodic memory (p = 0.004) per unit increase of temporal lobe tau-PET. Confirmatory analyses using the alternate index of modularity Q revealed consistent results. In conclusion, higher segregation of functional connections into distinct large-scale networks supports cognitive resilience in Alzheimer's disease. es_ES
dc.language.iso eng es_ES
dc.publisher Oxford es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Alzheimer Disease es_ES
dc.subject Enfermedad de Alzheimer es_ES
dc.subject Cognitive resilience es_ES
dc.subject Resiliencia cognitiva es_ES
dc.title Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Ewers, Michael. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Luan, Ying. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Frontzkowski, Lukas. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Neitzel, Julia. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Rubinski, Anna. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Dichgans, Martin. Ludwig-Maximilian-University; Alemania.
dc.description.fil Fil: Hassenstab, Jason. Washington University in St. Louis; Estados Unidos.
dc.description.fil Fil: Gordon, Brian A. Washington University in St. Louis; Estados Unidos.
dc.description.fil Fil: Chhatwal, Jasmeer P. Harvard Medical School; Estados Unidos.
dc.description.fil Fil: Levin, Johannes. Ludwig-Maximilians-Universität München; Alemania.
dc.description.fil Fil: Schofield, Peter R. Neuroscience Research Australia; Australia.
dc.description.fil Fil: Benzinger, Tammie L.S. Washington University in St Louis; Estados Unidos.
dc.description.fil Fil: Morris, John C. Washington University in St Louis; Estados Unidos.
dc.description.fil Fil: Goate, Alison M. Icahn School of Medicine at Mount Sinai; Estados Unidos.
dc.description.fil Fil: Karch, Celeste M. Washington University in St. Louis; Estados Unidos.
dc.description.fil Fil: Fagan, Anne M. Washington University in St. Louis; Estados Unidos.
dc.description.fil Fil: McDade, Eric. Washington University in St. Louis; Estados Unidos.
dc.description.fil Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.
dc.description.fil Fil: Berman, Sarah B. University of Pittsburgh; Estados Unidos.
dc.description.fil Fil: Chui, Helena C. Keck School of Medicine at the University of Southern California; Estados Unidos.
dc.relation.ispartofVOLUME 144
dc.relation.ispartofNUMBER 7
dc.relation.ispartofPAGINATION 2176-2185
dc.relation.ispartofCOUNTRY Reino Unido
dc.relation.ispartofCITY Oxford
dc.relation.ispartofTITLE Brain
dc.relation.ispartofISSN 1460-2156
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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