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Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination

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dc.contributor.author Cheli, Veronica Teresita
dc.contributor.author Correale, Jorge
dc.contributor.author Paez, Pablo M.
dc.contributor.author Pasquini, Juana María
dc.date.accessioned 2021-03-31T11:32:21Z
dc.date.available 2021-03-31T11:32:21Z
dc.date.issued 2020-01
dc.identifier.citation Cheli, V.T., Correale, J., Paez, P.M., Pasquini, J.M., 2020. Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination. ASN Neuro 12, 1759091420962681. https://doi.org/10.1177/1759091420962681 es_ES
dc.identifier.uri https://repositorio.fleni.org.ar/xmlui/handle/123456789/395
dc.identifier.uri https://doi.org/10.1177/1759091420962681
dc.description.abstract Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron excess may result in harmful effects in the CNS. Oligodendrocytes and astrocytes are crucial players in brain iron equilibrium. However, the mechanisms of iron uptake, storage, and efflux in oligodendrocytes and astrocytes during CNS development or under pathological situations such as demyelination are not completely understood. In the CNS, iron is directly required for myelin production as a cofactor for enzymes involved in ATP, cholesterol and lipid synthesis, and oligodendrocytes are the cells with the highest iron levels in the brain which is linked to their elevated metabolic needs associated with the process of myelination. Unlike oligodendrocytes, astrocytes do not have a high metabolic requirement for iron. However, these cells are in close contact with blood vessel and have a strong iron transport capacity. In several pathological situations, changes in iron homoeostasis result in altered cellular iron distribution and accumulation and oxidative stress. In inflammatory demyelinating diseases such as multiple sclerosis, reactive astrocytes accumulate iron and upregulate iron efflux and influx molecules, which suggest that they are outfitted to take up and safely recycle iron. In this review, we will discuss the participation of oligodendrocytes and astrocytes in CNS iron homeostasis. Understanding the molecular mechanisms of iron uptake, storage, and efflux in oligodendrocytes and astrocytes is necessary for planning effective strategies for iron management during CNS development as well as for the treatment of demyelinating diseases. es_ES
dc.language.iso eng es_ES
dc.publisher Sage es_ES
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/2.5/ar/
dc.subject Astrocytes es_ES
dc.subject Astrocitos es_ES
dc.subject Ferritins es_ES
dc.subject Ferritinas es_ES
dc.subject Oligodendroglia es_ES
dc.subject Oligodendroglía es_ES
dc.subject Remyelination es_ES
dc.subject Remielinización es_ES
dc.title Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.type info:eu-repo/semantics/publishedVersion
dc.description.fil Fil: Correale, Jorge. Fleni. Departamento de Neurología. Servicio de Neuroinmunología y Enfermedades Desmielinizantes; Argentina.
dc.description.fil Fil: Cheli, Veronica T. The State University of New York, University at Buffalo. Hunter James Kelly Research Institute. Jacobs School of Medicine and Biomedical Sciences. Department of Pharmacology and Toxicology; Estados Unidos.
dc.description.fil Fil: Paez, Pablo M. The State University of New York, University at Buffalo. Hunter James Kelly Research Institute. Jacobs School of Medicine and Biomedical Sciences. Department of Pharmacology and Toxicology; Estados Unidos.
dc.description.fil Fil: Pasquini, Juana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Instituto de Química y Fisicoquímica Biológicas; Argentina.
dc.relation.ispartofVOLUME 12
dc.relation.ispartofPAGINATION 1759091420962681
dc.relation.ispartofCOUNTRY Estados Unidos
dc.relation.ispartofCITY Thousand Oaks
dc.relation.ispartofTITLE ASN neuro : American Society for Neurochemistry neuro
dc.relation.ispartofISSN 1759-0914
dc.type.snrd info:ar-repo/semantics/artículo es_ES


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